公开(公告)号：WO2014073740A1

公开(公告)日：2014-05-15

申请号：PCT/KR2012/010659

申请日：2012-12-07

Applicant: 한국과학기술원

Inventor： 조광현 ,  최민수 ,  주시

IPC: A61K31/7105 ,  A61K31/7088 ,  A61P35/00

CPC classification number: A61K31/7105 ,  A61K31/404 ,  A61K31/497 ,  A61K31/5513 ,  A61K45/06 ,  A61K2300/00

Abstract: 본 발명은 악성종양의 효과적인 치료를 위하여, Wip1 저해제 및 Mdm-2/p53 상호작용 저해제를 유효성분으로 함유하는 종양 치료제를 제공한다.

Abstract translation: 本发明提供了包含作为活性成分的Wip1抑制剂和Mdm-2 / p53相互作用抑制剂的抗肿瘤药物，以有效治疗恶性肿瘤。

公开(公告)号：KR1020140059002A

公开(公告)日：2014-05-15

申请号：KR1020120125565

申请日：2012-11-07

Applicant: 한국과학기술원

Inventor： 조광현 ,  최민수 ,  주시

IPC: A61K48/00 ,  A61K31/7105 ,  A61K31/7088 ,  A61P35/00

CPC classification number: A61K31/7105 ,  A61K31/404 ,  A61K31/497 ,  A61K31/5513 ,  A61K45/06 ,  A61K2300/00

Abstract: The present invention provides an anti-tumor drug comprising, as active ingredients, Wip1 inhibitors and Mdm-2/p53 interaction inhibitors so as to effectively treat malignant tumors. According to an embodiment of the present invention, malignant tumors, such as multidrug-resistant tumors, can be effectively treated which were nearly impossible to treat with conventional anti-cancer drugs.

Abstract translation: 本发明提供了包含作为活性成分的Wip1抑制剂和Mdm-2 / p53相互作用抑制剂的抗肿瘤药物，以有效治疗恶性肿瘤。 根据本发明的一个实施方案，可以有效地治疗恶性肿瘤，例如多药耐药肿瘤，这几乎不可能用常规的抗癌药物治疗。