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公开(公告)号：WO2014073740A1
公开(公告)日：2014-05-15
申请号：PCT/KR2012/010659
申请日：2012-12-07
Applicant: 한국과학기술원
IPC: A61K31/7105 , A61K31/7088 , A61P35/00
CPC classification number: A61K31/7105 , A61K31/404 , A61K31/497 , A61K31/5513 , A61K45/06 , A61K2300/00
Abstract: 본 발명은 악성종양의 효과적인 치료를 위하여, Wip1 저해제 및 Mdm-2/p53 상호작용 저해제를 유효성분으로 함유하는 종양 치료제를 제공한다.
Abstract translation: 本发明提供了包含作为活性成分的Wip1抑制剂和Mdm-2 / p53相互作用抑制剂的抗肿瘤药物，以有效治疗恶性肿瘤。
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Patent Agency Ranking
公开(公告)号：KR1020160046038A
公开(公告)日：2016-04-28
申请号：KR1020140141024
申请日：2014-10-17
CPC classification number: G06F17/3087 , G06F17/30554
Abstract: 다양한실시예에따른위치기반소셜검색서비스를제공하는방법에있어서, 소셜네트워크시스템으로부터상기소셜검색서비스유저들의적어도어느한 장소의방문정보및 상기어느한 장소의관련리뷰데이터중 적어도하나를포함하는하나이상의방문기록정보를수집하여저장하는동작과; 상기방문기록정보에서토픽카테고리별토픽을선정하는동작과; 상기유저들중 적어도한 명의유저로부터위치기반쿼리를수신하면, 상기위치기반쿼리에서상기토픽카테고리별로토픽을추출하는동작과; 상기토픽카테고리별로, 상기위치기반쿼리에서추출된토픽및 상기방문기록정보에서선정된토픽간의관계를분석하여, 상기유저들중 적어도한 명을전문가로선정하는동작을포함함을특징으로한다. 다른실시예가가능하다.
Abstract translation: 各种实施例涉及用于提供基于位置的社会搜索服务的系统和方法。 该方法包括以下操作：从社交网络收集一个或多个访问记录信息，包括至少一个关于社交搜索服务用户的访问到至少一个地方的信息，以及审查与至少一个地方相关的数据 系统，并存储收集的访问记录信息; 在访问记录信息中为每个主题类别选择一个主题; 当从至少一个用户接收到基于位置的查询时，从基于位置的查询中提取每个主题类别的主题; 以及分析从基于位置的查询提取的主题与从每个主题类别的访问记录信息中选择的主题之间的相关性，以及作为专家来选择至少一个用户。 其他实施例是可能的。
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公开(公告)号：KR1020140032070A
公开(公告)日：2014-03-14
申请号：KR1020120098296
申请日：2012-09-05
Applicant: 한국과학기술원
Abstract: Disclosed is a method for analyzing network properties including the steps of: receiving data about a network which includes nodes and links; generating data about a modified network which is modified by selecting one or more of the nodes and the links and perturbing the (original) network; and computing the data regarding one or more of a point attractor, the basin of the point attractor, a cyclic attractor, and the basin of the cyclic attractor of the modified network. [Reference numerals] (S11) Receiving the data of a boolean network having a plurality of nodes and a plurality of links for connecting the nodes; (S12) Generating data about a modified network modified from the network by perturbing the boolean network as one or more control targets selected among the nodes and the links; (S13) Calculating data about one or more things among a point attractor, a point attractor basin, a cyclic attractor, and a cyclic attractor basin in the modified network; (S14~S17) Providing the result of comparing the information about a point attractor, a point attractor basin, a cyclic attractor, or a cyclic attractor basin in the boolean network with the information about a point attractor, a point attractor basin, a cyclic attractor or a cyclic attractor basin in the modified network
Abstract translation: 公开了一种分析网络特性的方法，包括以下步骤：接收关于包括节点和链路的网络的数据; 生成关于通过选择一个或多个节点和链路并扰乱（原始）网络来修改的修改的网络的数据; 以及计算关于点吸引子，点吸引子的流域，循环吸引子以及修改网络的循环吸引子的盆中的一个或多个的数据。 （附图标记）（S11）接收具有多个节点的布尔网络和用于连接节点的多个链路的数据; （S12）通过将布尔网络作为在节点和链路之间选择的一个或多个控制目标进行扰动来生成关于从网络修改的修改的网络的数据; （S13）在修改网络中计算点吸引子，点吸引子流域，循环吸引子和循环吸引子流域中的一个或多个事物的数据; （S14〜S17）提供在布尔网络中与点吸引子，点吸引子池，循环吸引子或循环吸引子池相关的信息与点吸引子的信息，点吸引子盆，循环 吸引子或循环吸引子盆
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公开(公告)号：KR101483789B1
公开(公告)日：2015-01-19
申请号：KR1020120098296
申请日：2012-09-05
Applicant: 한국과학기술원
Abstract: 노드와 링크를 포함하는 네트워크에 대한 데이터를 제공받는 단계, 상기 노드와 링크 중 하나 이상을 선택하여 상기 네트워크를 섭동함으로써 변형되는 변형 네트워크에 대한 데이터를 생성하는 단계, 및 상기 변형 네트워크가 갖는 '포인트 어트렉터', '포인트 어트렉터의 베이신', '사이클릭 어트렉터', 및 '사이클릭 어트렉터의 베이신' 중 하나 이상에 대한 데이터를 산출하는 단계를 포함하는 네트워크 특성 분석방법이 공개된다.
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公开(公告)号：KR1020140059002A
公开(公告)日：2014-05-15
申请号：KR1020120125565
申请日：2012-11-07
Applicant: 한국과학기술원
IPC: A61K48/00 , A61K31/7105 , A61K31/7088 , A61P35/00
CPC classification number: A61K31/7105 , A61K31/404 , A61K31/497 , A61K31/5513 , A61K45/06 , A61K2300/00
Abstract: The present invention provides an anti-tumor drug comprising, as active ingredients, Wip1 inhibitors and Mdm-2/p53 interaction inhibitors so as to effectively treat malignant tumors. According to an embodiment of the present invention, malignant tumors, such as multidrug-resistant tumors, can be effectively treated which were nearly impossible to treat with conventional anti-cancer drugs.
Abstract translation: 本发明提供了包含作为活性成分的Wip1抑制剂和Mdm-2 / p53相互作用抑制剂的抗肿瘤药物，以有效治疗恶性肿瘤。 根据本发明的一个实施方案，可以有效地治疗恶性肿瘤，例如多药耐药肿瘤，这几乎不可能用常规的抗癌药物治疗。
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