公开(公告)号：KR101127756B1

公开(公告)日：2012-03-23

申请号：KR1020110089182

申请日：2011-09-02

Applicant: 한국과학기술원

Inventor： 김은준 ,  강창원 ,  마원 ,  원혜정 ,  함은경 ,  김은진

IPC: A01K67/027 ,  C12N15/01 ,  G01N33/15

CPC classification number: A01K67/0276 ,  A01K2217/075 ,  A01K2227/105 ,  A01K2267/0356

Abstract: PURPOSE: A GIT1 gene deficient mouse and a drug screening method using the same are provided to analyze the reason of the attention-deficit hyperactivity disorder and to decipher various kinds of anxiety disorders and diseases. CONSTITUTION: A drug screening method using a GIT1 gene deficient mouse is as follows. A therapeutic agent candidate material of attention-deficit hyperactivity disorder(ADHD) of mammal except for the human is dosed. After the candidate material is administered, an attention-deficit hyperactivity disorder test of mammal except for the human is performed. The candidate material causing the reduction of the attention deficiency hyperactivity disorder is selected.

Abstract translation: 目的：提供GIT1基因缺陷小鼠及其使用药物筛选方法，分析注意力缺陷多动障碍的原因，解读各种焦虑症和疾病。 构成：使用GIT1基因缺陷小鼠的药物筛选方法如下。 给予哺乳动物除人之外的注意缺陷多动障碍（ADHD）的治疗剂候选物质。 在施用候选物质之后，进行除人之外的哺乳动物的注意缺陷多动障碍试验。 选择引起注意缺陷多动障碍减轻的候选物质。