公开(公告)号：KR1020030047567A

公开(公告)日：2003-06-18

申请号：KR1020010078270

申请日：2001-12-11

Applicant: 한국전자통신연구원

Inventor： 표현봉 ,  신용범 ,  정지욱 ,  김민곤 ,  이상경 ,  신동호 ,  박선희

IPC: G01B11/00

CPC classification number: G01N21/553

Abstract: PURPOSE: A surface plasmon resonance sensor system is provided to prevent a metal layer from being deformed by forming a transparent thin film on the metal layer and bonding the transparent thin film to the metal layer by using an adhesive layer. CONSTITUTION: A surface plasmon resonance sensor system includes a transparent substrate(13a). A first adhesive layer, a conductive thin film(13b), a second adhesive layer(13d), and a transparent layer(13e) are sequentially deposited on the transparent substrate(13a), thereby forming a sensor section of a sensor chip(13). A sample to be measured is positioned at an upper portion of the sensor chip(13). A prism(12) is attached to a lower portion of the sensor chip(13) in order to create a plasmon resonance by reacting with a surface of the conductive thin film(13b). A light source(11) is provided to supply light to the sensor chip(13) through the prism(12). A light receiving section(14) receives light reflected from the sensor chip(13).

Abstract translation: 目的：提供表面等离子体共振传感器系统，以通过在金属层上形成透明薄膜并通过使用粘合剂层将透明薄膜粘合到金属层来防止金属层变形。 构成：表面等离子体共振传感器系统包括透明基板（13a）。 顺序地在透明基板（13a）上淀积第一粘合层，导电薄膜（13b），第二粘合剂层（13d）和透明层（13e），从而形成传感器芯片（13）的传感器部分 ）。 要测量的样品位于传感器芯片（13）的上部。 棱镜（12）安装在传感器芯片（13）的下部，以便通过与导电薄膜（13b）的表面反应而产生等离子体共振。 提供光源（11）以通过棱镜（12）向传感器芯片（13）提供光。 光接收部分（14）接收从传感器芯片（13）反射的光。

公开(公告)号：KR100467315B1

公开(公告)日：2005-01-24

申请号：KR1020010085038

申请日：2001-12-26

Applicant: 한국전자통신연구원

Inventor： 김민곤 ,  표현봉 ,  신용범 ,  박선희 ,  이상경 ,  신동호

IPC: G01N33/53

Abstract: PURPOSE: A biosensor using a competitive bond and a device and a method for detecting biological samples using the same are provided, thereby indirectly detecting the biological samples using the competitive bond, so that the signal sensitivity of the biosensor can be increased. CONSTITUTION: A biosensor capable of selectively binding with the analyte-binding material(ABM) comprises a board, a metal thin layer on the board, biological sample-like materials having the similar structure to the biological samples and immobilized on the metal thin layer, wherein the biological sample is glucose; the ABM is concanavalin A, coenzyme-removed apo-glucose oxidase or glucose dehydrogenase; the board is glass; and the metal thin layer is gold thin layer. A device(200) for detecting biological samples(62) comprises (a) the biosensor(100) containing the metal thin layer(20) and biological sample-like materials having similar structure to the biological samples and immobilized on the metal thin layer; (b) a buffer solution(110) containing the biological samples and ABM; (c) a dielectric medium(120) formed on both surfaces of the glass board; (d) refraction rate matching oil between the glass board and the dielectric medium; (e) a light emitting portion(140) for applying light to the glass board through the dielectric medium; and (f) a light receiving portion(150) for measuring the light intensity reflected from the glass board.

Abstract translation: 目的：提供使用竞争键的生物传感器和使用该生物传感器检测生物样品的装置和方法，由此通过竞争键间接检测生物样品，从而可以提高生物传感器的信号灵敏度。 构成：能够选择性地与分析物结合材料（ABM）结合的生物传感器包括板，板上的金属薄层，具有与生物样品类似结构并固定在金属薄层上的生物样品样材料， 其中生物样品是葡萄糖; ABM是伴刀豆球蛋白A，辅酶去除的脱辅基葡萄糖氧化酶或葡萄糖脱氢酶; 板子是玻璃的; 金属薄层为金薄层。 一种用于检测生物样品（62）的装置（200），包括：（a）包含金属薄层（20）的生物传感器（100）和具有与生物样品相似结构并固定在金属薄层上的生物样品样物质; （b）含有生物样品和ABM的缓冲溶液（110）; （c）在玻璃板的两个表面上形成的电介质（120）; （d）玻璃板和电介质之间的折射率匹配油; （e）发光部分（140），用于通过电介质向玻璃板施加光; 和（f）用于测量从玻璃板反射的光强度的光接收部分（150）。

公开(公告)号：KR100407821B1

公开(公告)日：2003-12-01

申请号：KR1020010073283

申请日：2001-11-23

Applicant: 한국전자통신연구원

Inventor： 신용범 ,  표현봉 ,  정지욱 ,  이상경 ,  신동호 ,  김민곤 ,  박선희

IPC: G01N21/27

CPC classification number: G01N21/648 ,  B82Y20/00 ,  G01N21/645 ,  G02B6/1226 ,  G02B6/134

Abstract: An active ion-doped waveguide-plasmon resonance (AID WPR) sensor based on plasmon surface resonance (PSR) and an imaging system using the sensor are provided. An additional dielectric thin film doped with active ions and acting as a waveguide is formed on a metal thin film. The active ions are excited by an incident light beam and fluoresce light of a shorter wavelength than the incident light beam through upconversion coupled to surface plasmon resonance, thereby increasing fluorescence intensity variations with respect to incident light angle variations. The AID WPR sensor and the imaging system can detect a minor refractive index variation of a sample, which could not be measured using an existing SPR sensor, or a trace adsorbed material, with 100 times larger refractive index resolution than the existing SPR sensor.

Abstract translation: 提供基于等离子体表面共振（PSR）的活性离子掺杂波导 - 等离子体共振（AID WPR）传感器和使用该传感器的成像系统。 掺杂有活性离子并用作波导的另外的电介质薄膜形成在金属薄膜上。 通过与表面等离子体共振耦合的上转换，活性离子被入射光束激发并发出比入射光束短的波长的光，由此相对于入射光角度变化增加荧光强度变化。 AID WPR传感器和成像系统可以检测样品的较小折射率变化，该变化无法使用现有SPR传感器或痕量吸附材料测量，其折射率分辨率比现有SPR传感器高100倍。

公开(公告)号：KR1020030042576A

公开(公告)日：2003-06-02

申请号：KR1020010073283

申请日：2001-11-23

Applicant: 한국전자통신연구원

Inventor： 신용범 ,  표현봉 ,  정지욱 ,  이상경 ,  신동호 ,  김민곤 ,  박선희

IPC: G01N21/27

CPC classification number: G01N21/648 ,  B82Y20/00 ,  G01N21/645 ,  G02B6/1226 ,  G02B6/134

Abstract: PURPOSE: A waveguide-plasmon resonance sensor and an image system are provided to improve sensitivity of the waveguide-plasmon resonance sensor by coating a dielectric thin film doped with active ions on a metal layer as a waveguide. CONSTITUTION: An active ion doped waveguide-plasmon resonance sensor includes a conductive film(122) for providing surface plasmon and a dielectric medium(110) aligned at one side of the conductive film(122). A light source(130) radiates incident light, which is incident into the conductive film(122) through the dielectric medium(110). A dielectric film is coated on the other side of the conductive film(122). A sample(123) is attached to the dielectric film. Active ions(171) are doped into the dielectric film. Active ions(171) are excited by incident light(131), thereby generating fluorescent light(139). A light receiving section(140) is provided to measure intensity of fluorescent light(139).

Abstract translation: 目的：提供波导 - 等离子体共振传感器和图像系统，以通过在金属层上涂覆掺杂有活性离子的介电薄膜作为波导来提高波导 - 等离子体共振传感器的灵敏度。 构成：主动离子掺杂波导 - 等离子体共振传感器包括用于提供表面等离子体激元的导电膜（122）和在导电膜（122）的一侧对准的电介质（110）。 光源（130）通过电介质（110）辐射入射到导电膜（122）中的入射光。 在导电膜（122）的另一侧上涂覆有电介质膜。 样品（123）附着在电介质膜上。 活性离子（171）被掺杂到电介质膜中。 活性离子（171）被入射光（131）激发，从而产生荧光（139）。 提供光接收部分（140）以测量荧光的强度（139）。

公开(公告)号：KR1020030055483A

公开(公告)日：2003-07-04

申请号：KR1020010085038

申请日：2001-12-26

Applicant: 한국전자통신연구원

Inventor： 김민곤 ,  표현봉 ,  신용범 ,  박선희 ,  이상경 ,  신동호

IPC: G01N33/53

Abstract: PURPOSE: A biosensor using a competitive bond and a device and a method for detecting biological samples using the same are provided, thereby indirectly detecting the biological samples using the competitive bond, so that the signal sensitivity of the biosensor can be increased. CONSTITUTION: A biosensor capable of selectively binding with the analyte-binding material(ABM) comprises a board, a metal thin layer on the board, biological sample-like materials having the similar structure to the biological samples and immobilized on the metal thin layer, wherein the biological sample is glucose; the ABM is concanavalin A, coenzyme-removed apo-glucose oxidase or glucose dehydrogenase; the board is glass; and the metal thin layer is gold thin layer. A device(200) for detecting biological samples(62) comprises (a) the biosensor(100) containing the metal thin layer(20) and biological sample-like materials having similar structure to the biological samples and immobilized on the metal thin layer; (b) a buffer solution(110) containing the biological samples and ABM; (c) a dielectric medium(120) formed on both surfaces of the glass board; (d) refraction rate matching oil between the glass board and the dielectric medium; (e) a light emitting portion(140) for applying light to the glass board through the dielectric medium; and (f) a light receiving portion(150) for measuring the light intensity reflected from the glass board.

Abstract translation: 目的：提供使用竞争性键的生物传感器和使用其的装置和检测生物样品的方法，从而间接地利用竞争性键检测生物样品，从而可以提高生物传感器的信号灵敏度。 构成：能够与分析物结合材料（ABM）选择性结合的生物传感器包括板，板上的金属薄层，具有与生物样品相似结构并固定在金属薄层上的生物样品样材料， 其中所述生物样品是葡萄糖; ABM是伴刀豆球蛋白A，辅酶去除的载脂蛋白氧化酶或葡萄糖脱氢酶; 董事会是玻璃; 金属薄层是金薄层。 用于检测生物样品（62）的装置（200）包括：（a）含有金属薄层（20）的生物传感器（100）和具有与生物样品相似结构并固定在金属薄层上的生物样品样材料; （b）含有生物样品和ABM的缓冲溶液（110）; （c）形成在所述玻璃板的两个表面上的电介质（120） （d）玻璃板和电介质之间的折射率匹配油; （e）用于通过电介质向玻璃板施加光的发光部分（140）; 和（f）用于测量从玻璃板反射的光强度的光接收部分（150）。