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    항암 활성을 갖는 페난트렌 락탐 유도체, 이의 제조방법 및이를 포함하는 약학 조성물
    1.
    发明公开
    항암 활성을 갖는 페난트렌 락탐 유도체, 이의 제조방법 및이를 포함하는 약학 조성물 失效
    具有抗癌活性的苯丙氨酸衍生物衍生物，其制备方法和含有其的药物组合物

    公开(公告)号：KR1020090039038A

    公开(公告)日：2009-04-22

    申请号：KR1020070104435

    申请日：2007-10-17

    Applicant: 한국화학연구원

    Inventor： 허정녕 ,  김범태 ,  민용기 ,  최상운 ,  이혁 ,  장성연 ,  박노균 ,  김좌겸 ,  김영하 ,  박미경

    IPC: C07D209/90 ,  A61K31/403 ,  A61P35/00

    CPC classification number: C07D491/04

    Abstract: A phenanthrene lactam derivative having the anticancer activity is provided to prevent and treat cancer and disease with excellent anticancer activity. A phenanthrene lactam derivative having chemical formula 1 is produced by reaction of the compound of chemical formula 2 and the compound of chemical formula 3 in a solution. R1, R2, R3, R4, R5, R6 and R7R is hydrogen, halogen, hydroxy, C1-6 alkyl, C1-6 alkoxy or aryloxy. R4 and R5, R5 and R6, or R6 and R7 forms dioxol. R8 is the hydrogen or the C1-6 alkyl. The composite for preventing caner and pharmaceutical treatment comprises the phenanthrene lactam derivative of chemical formula 1 or pharmaceutically allowable salt.

    Abstract translation: 提供具有抗癌活性的菲内酰胺衍生物，以预防和治疗具有优异抗癌活性的癌症和疾病。 具有化学式1的菲内酰胺衍生物通过化学式2的化合物和化学式3的化合物在溶液中的反应来制备。 R1，R2，R3，R4，R5，R6和R7R是氢，卤素，羟基，C1-6烷基，C1-6烷氧基或芳氧基。 R4和R5，R5和R6，或R6和R7形成二氧杂环戊烯。 R8是氢或C1-6烷基。 用于预防癌症和药物治疗的复合物包括化学式1的菲内酰胺衍生物或药学上可允许的盐。

    페난트렌 유도체의 제조방법
    4.
    发明公开
    페난트렌 유도체의 제조방법 无效
    制备衍生物衍生物的方法

    公开(公告)号：KR1020080093792A

    公开(公告)日：2008-10-22

    申请号：KR1020070038001

    申请日：2007-04-18

    Applicant: 한국화학연구원

    Inventor： 허정녕 ,  김범태 ,  민용기 ,  이혁 ,  장성연 ,  박노균 ,  김영하

    IPC: C07C49/675 ,  C07C49/737 ,  C07C321/22 ,  C07F5/02

    Abstract: A method for preparing phenanthrene derivatives is provided to obtain various phenanthrene derivatives useful in various industrial fields with high yield in a simple manner. A method for preparing phenanthrene derivatives comprises a step of reacting a compound represented by the following formula 2 with a compound represented by the following formula 3 in a solvent in the presence of a palladium compound and a base. In the formulae, Y is C=O or SO2; R1 is H, OH, C1-C6 alkyl, C1-C6 alkoxy, NR11R12, or substituted or non-substituted C3-C7 aryl, or Y-R1 is cyano, if appropriate; each of R2, R3, R4, R5, R6, R7, R8 and R9 is H, halogen, OH, cyano, nitro, NR11R12, C1-C6 alkyl, C1-C6 haloalkyl, C1-C6 alkoxy, C2-C8 alkenyl, C2-C4 alkynyl, C3-C8 cycloalkyl, C1-C4 alkoxy, C1-C4 alkyl, C3-C8 cycloalkoxy-C1-C4 alkyl, C1-C6 alkoxycarbonyl, C1-C6 alkylaminocarbonyl or C1-C8 alkylsulfonyl; R10 is H, OH, C1-C6 alkyl, C1-C6 haloalkyl, or substituted or non-substituted C3-C7 aryl; each of R11 and R12 is H, C1-C6 alkyl, C1-C6 alkoxy or C3-C7 cycloalkyl, or R11 and R12 form a 3- to-7-membered non-aromatic heterocyclic ring together with the nitrogen atom to which they are attached; aromatic rings A and D each represent a heteroaryl; and each of X and M represents a selected from halogen, C1-C6 alkylsulfonyloxy and arylsulfonyloxy, or b selected from B(OH)2 and B(OR13)2, wherein R13 is C1-C4 alkyl or two R13s are linked to each other to form a methyl-substituted heterocyclic ring together with B and O, with the proviso that when X is a, M is b, and when x is b, M is a.

    Abstract translation: 提供一种制备菲衍生物的方法，以简单的方式获得在各种工业领域中用于高产率的各种菲衍生物。 制备菲衍生物的方法包括在溶剂中，在钯化合物和碱的存在下，使由下式2表示的化合物与下式3表示的化合物反应的步骤。 在式中，Y为C = O或SO 2; R 1为H，OH，C 1 -C 6烷基，C 1 -C 6烷氧基，NR 11 R 12或取代或未取代的C 3 -C 7芳基，或Y-R 1为氰基; R2，R3，R4，R5，R6，R7，R8和R9中的每一个为H，卤素，OH，氰基，硝基，NR11R12，C1-C6烷基，C1-C6卤代烷基，C1-C6烷氧基，C2-C8烯基， C 2 -C 4炔基，C 3 -C 8环烷基，C 1 -C 4烷氧基，C 1 -C 4烷基，C 3 -C 8环烷氧基-C 1 -C 4烷基，C 1 -C 6烷氧基羰基，C 1 -C 6烷基氨基羰基或C 1 -C 8烷基磺酰基; R 10是H，OH，C 1 -C 6烷基，C 1 -C 6卤代烷基或取代或未取代的C 3 -C 7芳基; R 11和R 12中的每一个是H，C 1 -C 6烷基，C 1 -C 6烷氧基或C 3 -C 7环烷基，或者R 11和R 12与它们所在的氮原子一起形成3至7元非芳族杂环 连接; 芳环A和D各自表示杂芳基; 并且X和M各自表示选自卤素，C 1 -C 6烷基磺酰氧基和芳基磺酰氧基或选自B（OH）2和B（OR 13）2）的b，其中R 13是C 1 -C 4烷基或两个R 13彼此连接 与B和O一起形成甲基取代的杂环，条件是当X为a时，M为b，当x为b时，M为a。

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