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    신규 6-플루오로퓨린화합물과 그 제조방법
    2.
    发明授权
    신규 6-플루오로퓨린화합물과 그 제조방법 失效
    新的6-氟嘌呤化合物及其制备

    公开(公告)号：KR1019910000442B1

    公开(公告)日：1991-01-25

    申请号：KR1019880015088

    申请日：1988-11-16

    Applicant: 한국화학연구원

    Inventor： 김대기 ,  김희갑 ,  채영복

    IPC: C07D473/32

    Abstract: 6-Fluoropurine derivatives of formula (I) were prepared by (i) a nucleophilic substitution reaction of 6-chloropurine cpd. of formula (II) with trimethylamine in dimethylformamide solvent to produce purinetrimethyl ammonium of formula (III), and (ii) a nucleophilic substitution reaction of cpd. (III) with potassium fluoride in dimethylformamide solvent. In the formulas, X= O or S; and Y= H or hydroxymethyl.

    Abstract translation: 通过（i）6-氯嘌呤cpd的亲核取代反应制备式（I）的6-氟嘌呤衍生物。 式（II）与二甲基甲酰胺溶剂中的三甲胺反应以制备式（III）的三（三乙基铵）铵，和（ii）cpd的亲核取代反应。 （III）与氟化钾在二甲基甲酰胺溶剂中反应。 在式中，X = O或S; 和Y = H或羟甲基。

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