公开(公告)号：KR1020020017696A

公开(公告)日：2002-03-07

申请号：KR1020000051188

申请日：2000-08-31

Applicant: 한국화학연구원

Inventor： 심영기 ,  서은영

IPC: C07D487/22

Abstract: PURPOSE: Provided is a porphyrin derivative of the formula(1) which is useful as a photosensitizer in photodynamic therapy(PDT) applied to incurable diseases, such as cancer and the like. CONSTITUTION: The porphyrin derivative is represented by the formula(1), wherein R1, R2, R3, R4, R5, R6, R7 and R8 are identical or different each other, and represent hydrogen, an alkyl group or a heteroalkyl group containing a hetero atom; A1, A2, A3 and A4 are identical or different each other, and represent hydrogen, an alkyl group, a heteroalkyl group containing a hetero atom, an alkenyl group, a substituted or unsubstituted aryl group(wherein, a substituent is selected from a hydroxy group and a C1-C6 alkyl group) or a heteroaryl group; the alkyl group and alkenyl group represent a C1-C6 linear or branched hydrocarbon cycle; and the porphyrin derivative can be metalloporphyrin binding to a transition metal containing nickel.

Abstract translation: 目的：提供式（1）的卟啉衍生物，其可用作光敏剂治疗（PDT）中应用于不可治愈疾病如癌症等的光敏剂。 构成：卟啉衍生物由式（1）表示，其中R 1，R 2，R 3，R 4，R 5，R 6，R 7和R 8相同或不同，表示氢，烷基或含有 杂原子 A1，A2，A3和A4彼此相同或不同，表示氢，烷基，含杂原子的杂烷基，烯基，取代或未取代的芳基（其中，取代基选自羟基 基团和C1-C6烷基）或杂芳基; 烷基和烯基表示C1-C6直链或支链烃循环; 并且卟啉衍生物可以是与含镍的过渡金属结合的金属卟啉。

公开(公告)号：KR100390771B1

公开(公告)日：2003-07-10

申请号：KR1020000051188

申请日：2000-08-31

Applicant: 한국화학연구원

Inventor： 심영기 ,  서은영

IPC: C07D487/22

Abstract: PURPOSE: Provided is a porphyrin derivative of the formula(1) which is useful as a photosensitizer in photodynamic therapy(PDT) applied to incurable diseases, such as cancer and the like. CONSTITUTION: The porphyrin derivative is represented by the formula(1), wherein R1, R2, R3, R4, R5, R6, R7 and R8 are identical or different each other, and represent hydrogen, an alkyl group or a heteroalkyl group containing a hetero atom; A1, A2, A3 and A4 are identical or different each other, and represent hydrogen, an alkyl group, a heteroalkyl group containing a hetero atom, an alkenyl group, a substituted or unsubstituted aryl group(wherein, a substituent is selected from a hydroxy group and a C1-C6 alkyl group) or a heteroaryl group; the alkyl group and alkenyl group represent a C1-C6 linear or branched hydrocarbon cycle; and the porphyrin derivative can be metalloporphyrin binding to a transition metal containing nickel.

Abstract translation: 用途：提供了一种式（1）的卟啉衍生物，其用作光动力治疗（PDT）中用于治疗癌症等不治之症的光敏剂。 构成：卟啉衍生物由式（1）表示，其中R 1，R 2，R 3，R 4，R 5，R 6，R 7和R 8彼此相同或不同，并且表示氢，烷基或杂烷基， 杂原子; A 1，A 2，A 3和A 4彼此相同或不同，并且表示氢，烷基，含有杂原子的杂烷基，烯基，取代或未取代的芳基（其中，取代基选自羟基 基团和C1-C6烷基）或杂芳基; 烷基和烯基代表C1-C6直链或支链烃循环; 并且卟啉衍生物可以是金属卟啉与含镍过渡金属的结合。