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公开(公告)号：KR1019960022455A
公开(公告)日：1996-07-18
申请号：KR1019940037752
申请日：1994-12-28
Applicant: 한국화학연구원
IPC: C07C321/24 , C07C319/20 , C07D205/09
Abstract: 크로틸 알코올로부터 높은 광학 활성을 갖는 하기 일반식(Ⅰ)의 히드록시기가 보호된 3-히드록시-1-부텐일 페닐 설파이드 유도체를 제조하였다.
식중, R
1 은 0
- , m
- 및 p
- 의 위치가 수소 원자, 할로겐 원자, C
1 내지 C
6 의 알킬기, C
1 내지 C
6 의 알콕시기, 또는 아릴기로 갈거나 다르게 치환되어 있는 페닐기이고, R
2 는 히드록시 보호기이다.-
公开(公告)号：KR100035591B1
公开(公告)日：1990-08-31
申请号：KR1019880002223
申请日：1988-03-04
Applicant: 한국화학연구원
IPC: C07D501/24 , C07D501/22
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3.发明公开2,6- 디 저급 알킬-4- 치환 페닐-1,4- 디하이드로 피리딘-3,5- 디카르복실산 에스테르 유도체의 제조 방법 无效2,6-二 - 低级烷基-4-取代苯基-1,4-二氢吡啶-3,5-二羧酸酯衍生物的制备
公开(公告)号：KR1019890011843A
公开(公告)日：1989-08-22
申请号：KR1019880000594
申请日：1988-01-26
Applicant: 한국화학연구원
IPC: C07D211/82
Abstract: 내용 없음
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4.发明公开2,6-디 저급 알킬-4- 치환 페닐-1,4- 디하이드로 피리딘-3,5 디 카르복실산 모노 에스테르 유도체의 제조 방법 无效2,6-二 - 低级烷基-4-取代苯基-1,4-二氢吡啶-3,5-二羧酸单酯衍生物的制备
公开(公告)号：KR1019890006586A
公开(公告)日：1989-06-14
申请号：KR1019870011411
申请日：1987-10-14
Applicant: 한국화학연구원
IPC: C07D211/80
Abstract: 내용 없음
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公开(公告)号：KR100501840B1
公开(公告)日：2005-07-20
申请号：KR1020000051187
申请日：2000-08-31
Applicant: 한국화학연구원
IPC: C07D487/22
Abstract: 본 발명은 조류로부터 알킬 피로페오포르바이드 a의 제조방법에 관한 것으로서, 더욱 상세하게는 조류 특히 남조류 또는 녹조류로부터 광역학 치료에 유용한 알킬 피로페오포르바이드 a를 고순도 및 고수율로 추출하는 방법에 관한 것이다.
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Patent Agency Ranking
公开(公告)号：KR100475244B1
公开(公告)日：2005-03-10
申请号：KR1020020036636
申请日：2002-06-28
Applicant: 한국화학연구원
IPC: C07C231/12
Abstract: 본 발명은 아토르바스타틴(상품명:리피토)을 제조하기 위한 핵심 중간체인, 4-(4-플루오르페닐)-2-이소부티릴-3-페닐-4-옥소-
N -페닐-부티르아미드의 효율적인 제조방법에 관한 것으로서, 4-메틸-3-옥소-
N -페닐펜타미드와 2-할로-1-(4-플루오르페닐)-2-페논 또는 2,2-디할로-1-(4-플루오르페닐)-2-페논을 염기 존재 하에서 친핵성 치환반응시키는 본 발명에 따르면 온화한 조건에서 높은 수율로 아트로바스타틴 제조용 중간체를 수득할 수 있다.-
公开(公告)号：KR100460449B1
公开(公告)日：2004-12-08
申请号：KR1020010072183
申请日：2001-11-20
Applicant: 한국화학연구원
IPC: C07C69/743
Abstract: PURPOSE: A method for preparing bifenthrin is provided, to obtain bifenthrin with the improved production yield under the milder condition by employing the thioacyl dithiophosphate as an intermediate. CONSTITUTION: The method comprises the steps of reacting the 3-(2-chloro-3,3,3-trifluoro-1-propenyl)-2,2-dimethyl cyclopentane carboxylic acid alkyl ester represented by the formula 2 with the dithiophosphate represented by the formula 3 to prepare the thioacyl dithiophosphate represented by the formula 4; and reacting the thioacyl dithiophosphate of the formula 4 with the 2-methyl-biphenyl-3-yl-methanol represented by the formula 5 to prepare the bifenthrin represented by the formula 1, wherein R1 and R2 are an alkyl group of C1-C6, respectively. Preferably the first step is carried out with stirring the mixture in the presence of an amine base; and the second step is carried out in the presence of an amine base at a room temperature.
Abstract translation: 目的：提供一种制备联苯菊酯的方法，通过使用硫代酰基二硫代磷酸酯作为中间体，在较温和的条件下获得具有提高的产量的联苯菊酯。 构成：该方法包括使由式2表示的3-（2-氯-3,3,3-三氟-1-丙烯基）-2,2-二甲基环戊烷羧酸烷基酯与由式2表示的二硫代磷酸酯 用于制备由式4表示的硫代酰基二硫代磷酸酯的式3; 并使式4的硫代酰基二硫代磷酸酯与式5代表的2-甲基 - 联苯-3-基 - 甲醇反应，以制备式1代表的联苯菊酯，其中R1和R2为C1-C6烷基， 分别。 优选地，第一步骤是在胺碱存在下搅拌混合物进行的; 第二步在室温下在胺碱存在下进行。
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公开(公告)号：KR100390771B1
公开(公告)日：2003-07-10
申请号：KR1020000051188
申请日：2000-08-31
Applicant: 한국화학연구원
IPC: C07D487/22
Abstract: PURPOSE: Provided is a porphyrin derivative of the formula(1) which is useful as a photosensitizer in photodynamic therapy(PDT) applied to incurable diseases, such as cancer and the like. CONSTITUTION: The porphyrin derivative is represented by the formula(1), wherein R1, R2, R3, R4, R5, R6, R7 and R8 are identical or different each other, and represent hydrogen, an alkyl group or a heteroalkyl group containing a hetero atom; A1, A2, A3 and A4 are identical or different each other, and represent hydrogen, an alkyl group, a heteroalkyl group containing a hetero atom, an alkenyl group, a substituted or unsubstituted aryl group(wherein, a substituent is selected from a hydroxy group and a C1-C6 alkyl group) or a heteroaryl group; the alkyl group and alkenyl group represent a C1-C6 linear or branched hydrocarbon cycle; and the porphyrin derivative can be metalloporphyrin binding to a transition metal containing nickel.
Abstract translation: 用途：提供了一种式（1）的卟啉衍生物，其用作光动力治疗（PDT）中用于治疗癌症等不治之症的光敏剂。 构成：卟啉衍生物由式（1）表示，其中R 1，R 2，R 3，R 4，R 5，R 6，R 7和R 8彼此相同或不同，并且表示氢，烷基或杂烷基， 杂原子; A 1，A 2，A 3和A 4彼此相同或不同，并且表示氢，烷基，含有杂原子的杂烷基，烯基，取代或未取代的芳基（其中，取代基选自羟基 基团和C1-C6烷基）或杂芳基; 烷基和烯基代表C1-C6直链或支链烃循环; 并且卟啉衍生物可以是金属卟啉与含镍过渡金属的结合。
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公开(公告)号：KR1020030041410A
公开(公告)日：2003-05-27
申请号：KR1020010072183
申请日：2001-11-20
Applicant: 한국화학연구원
IPC: C07C69/743
Abstract: PURPOSE: A method for preparing bifenthrin is provided, to obtain bifenthrin with the improved production yield under the milder condition by employing the thioacyl dithiophosphate as an intermediate. CONSTITUTION: The method comprises the steps of reacting the 3-(2-chloro-3,3,3-trifluoro-1-propenyl)-2,2-dimethyl cyclopentane carboxylic acid alkyl ester represented by the formula 2 with the dithiophosphate represented by the formula 3 to prepare the thioacyl dithiophosphate represented by the formula 4; and reacting the thioacyl dithiophosphate of the formula 4 with the 2-methyl-biphenyl-3-yl-methanol represented by the formula 5 to prepare the bifenthrin represented by the formula 1, wherein R1 and R2 are an alkyl group of C1-C6, respectively. Preferably the first step is carried out with stirring the mixture in the presence of an amine base; and the second step is carried out in the presence of an amine base at a room temperature.
Abstract translation: 目的：提供一种用于制备联苯菊酯的方法，通过使用硫代酰基二硫代磷酸酯作为中间体，在较温和的条件下获得具有改善的产率的联苯菊酯。 构成：该方法包括使由式2表示的3-（2-氯-3,3,3-三氟-1-丙烯基）-2,2-二甲基环戊烷羧酸烷基酯与由式2表示的二硫代磷酸酯 式3制备由式4表示的硫代酰基二硫代磷酸酯; 并使式4的硫代酰基二硫代磷酸酯与式5表示的2-甲基 - 联苯-3-基 - 甲醇反应，制备由式1表示的联苯菊酯，其中R1和R2是C1-C6烷基， 分别。 优选地，在胺基存在下搅拌混合物进行第一步骤; 第二步是在室温下在胺碱的存在下进行。
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公开(公告)号：KR1019900001854B1
公开(公告)日：1990-03-24
申请号：KR1019880002223
申请日：1988-03-04
Applicant: 한국화학연구원
IPC: C07D501/24 , C07D501/22
Abstract: Cephem derivs. of formula (I) are prepd. by (a) protecting amino gp. of 7-aminocephalosporanilic acid, (b) protecting carboxylic gp. on 4- position with methyl halide or diazomethane, (c) removing amino- protective gp., and (d) hydrolyzing with PLE (pig liver esterase) in an acetone aq. soln. In (I), R=H, (un)substd. alkyl, halogen, (un) substd. alkenyl or aromatic hetero gp.
Abstract translation: Cephem派生。 式（I）的化合物是制备的。 通过（a）保护氨基gp。 的7-氨基头孢烷酸，（b）保护羧基gp。 在甲基卤化物或重氮甲烷的4-位上，（c）除去氨基保护性gp，和（d）用丙酮水溶液中的PLE（猪肝酯酶）水解。 SOLN。 在（I）中，R = H，（un）。 烷基，卤素（（un））。 烯基或芳族杂原子
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