公开(公告)号：KR1020100026239A

公开(公告)日：2010-03-10

申请号：KR1020080085164

申请日：2008-08-29

Applicant: 한국화학연구원

Inventor： 김문환 ,  도준호 ,  서지수

IPC: C07D311/92 ,  C09K9/02

Abstract: PURPOSE: A novel method for economically manufacturing naphthopyran based photochromic dye of high yield and high purity is provided. CONSTITUTION: A method for manufacturing naphthopyran based photochromic dye of chemical formula 1 comprises: a step of reacting amino naphtholic acid with alkyl- or benzyl-chloroformate to obtain a compound of chemical formula 4; a step of substituting the compound of chemical formula 4 with amine compound to obtain a compound of chemical formula 2; a step of reacting halogen-substituted benzo phenone with nucleophilic compound under the presence of base and reacting with sodium acetylide to obtain a compound of chemical formula 3; and a step of reacting the compound of chemical formula 3 with a compound of chemical formula 2.

Abstract translation: 目的：提供一种经济地制备高产率，高纯度的萘并吡喃基光致变色染料的新方法。 构成：制备化学式1的萘并吡喃基光致变色染料的方法包括：使氨基萘酚与烷基或苄基氯甲酸酯反应得到化学式4化合物的步骤; 用胺化合物代替化学式4的化合物以获得化学式2的化合物的步骤; 在碱存在下使卤素取代的苯并苯酮与亲核化合物反应并与乙炔化钠反应以获得化学式3化合物的步骤; 和使化学式3的化合物与化学式2的化合物反应的步骤。

公开(公告)号：KR101344765B1

公开(公告)日：2013-12-24

申请号：KR1020110143415

申请日：2011-12-27

Applicant: 주식회사 팜한농 ,  한국화학연구원

Inventor： 류재욱 ,  고영관 ,  김종근 ,  서지수 ,  구동완 ,  김경성 ,  최인영 ,  홍미숙 ,  김태준 ,  안희근 ,  김시용

IPC: C07D413/14 ,  C07D413/12 ,  C07D401/14 ,  A01N43/76

Abstract: 본발명은하이드록시알킬벤즈아마이드화합물을고리화반응시켜 4,5-디히드로옥사졸-2-일벤젠화합물또는이의염을제조하는방법에관한것이다.

公开(公告)号：KR101069699B1

公开(公告)日：2011-10-04

申请号：KR1020080085164

申请日：2008-08-29

Applicant: 한국화학연구원

Inventor： 김문환 ,  도준호 ,  서지수

IPC: C07D311/92 ,  C09K9/02

Abstract: 본발명은나프토피란계의광변색염료의신규제조방법에관한것으로서, 기존의방법보다합성수율이높으며경제적으로수득할수 있다.

公开(公告)号：KR1020130075163A

公开(公告)日：2013-07-05

申请号：KR1020110143415

申请日：2011-12-27

Applicant: 주식회사 팜한농 ,  한국화학연구원

Inventor： 류재욱 ,  고영관 ,  김종근 ,  서지수 ,  구동완 ,  김경성 ,  최인영 ,  홍미숙 ,  김태준 ,  안희근 ,  김시용

IPC: C07D413/14 ,  C07D413/12 ,  C07D401/14 ,  A01N43/76

Abstract: PURPOSE: A method for preparing 4,5-dihydrooxazol-2-ylbenzene derivatives is provided to have a relatively mild reaction condition, to easily handle a reagent, and to synthesize the 4,5-dihydrooxazol-2-ylbenzene derivatives with high yield. CONSTITUTION: A method for preparing 4,5-dihydrooxazole-2-ylbenzene compound of chemical formula 1 or a salt thereof comprises the step of cyclizing a hydroxyalkyl benzamide of chemical formula 2 under the presence of (diethylamino)sulfur trifluoride (DAST) or para-toluene sulfonate (TsOH). The cyclization is performed under the presence of a base selected from the group consisting of tray (C_1-C_6) alkyl amine, alkali metal or hydroxide of the alkali earth metal, hydroxide, and C_1-C_6 alkoxide. The base is selected from the group consisting of trimethyl amine, triethyl amine, diethyl isopropyl amine, lithium hydroxide, sodium hydroxide, calcium hydroxide, sodium hydroxide, potassium hydroxide, sodium methoxide, and potassium methoxide.

Abstract translation: 目的：提供一种制备4,5-二氢恶唑-2-基苯衍生物的方法以具有相对温和的反应条件，容易处理试剂，并以高产率合成4,5-二氢恶唑-2-基苯衍生物。 构成：用于制备化学式1的4,5-二氢恶唑-2-基苯化合物或其盐的方法包括在（二乙基氨基）三氟化硫（DAST）或对位基团的存在下使化学式2的羟基烷基苯甲酰胺环化的步骤 - 甲苯磺酸盐（TsOH）。 环化是在碱土金属的碱土金属，碱金属或氢氧化物的塔板（C_1-C_6）烷基胺，碱金属或氢氧化物，C_1-C_6烷氧基化物的碱存在下进行的。 碱选自三甲胺，三乙胺，二乙基异丙胺，氢氧化锂，氢氧化钠，氢氧化钙，氢氧化钠，氢氧化钾，甲醇钠和甲醇钾组成的组。