公开(公告)号：KR1020100041799A

公开(公告)日：2010-04-22

申请号：KR1020107002073

申请日：2008-06-26

Applicant: 한국화학연구원

Inventor： 구오혼지안 ,  김정은 ,  이일영 ,  미첼마이클엘 ,  로데스게리 ,  손종찬 ,  쉬리안홍

IPC: C07D239/54 ,  C07D401/04 ,  A61K31/506 ,  A61P31/18

CPC classification number: A61K31/513 ,  A61K31/496 ,  A61K31/536 ,  A61K31/551 ,  A61K31/66 ,  A61K31/7048 ,  A61K31/7072 ,  A61K31/708 ,  A61K39/39558 ,  A61K45/06 ,  C07D239/54 ,  C07D239/545 ,  C07D239/553 ,  C07D239/60 ,  C07D401/04 ,  C07D403/04

Abstract: PURPOSE: A compound of suppressing a novel HIV reverse transcriptase is provided to suppress both wild type HIV strain and mutant type HIV strain and to treat AIDS. CONSTITUTION: A compound suppressing a novel HIV reverse trascriptase is denoted by chemical formula I. HIV infection is treated by mixing a compound of chemical formula I, compound suppressing HIV protease, HIV non-nucleoside reverse transcriptase inhibitor, HIV nucleoside reverse transcriptase inhibitor, HIV nucleotide reverse transcriptase inhibitor, HIV integrase inhibitor, gp41 inhibitor, CXCR4 inhibitor, gp120 inhibitor, G6PD and NADH-oxidase inhibitor, CCR5 inhibitor, other HIV drug, or mixture thereof.

Abstract translation: 目的：提供抑制新型HIV逆转录酶的化合物以抑制野生型HIV菌株和突变型HIV病毒株，并治疗AIDS。 构成：抑制新型HIV逆转录酶的化合物由化学式I表示。HIV感染通过混合化学式I化合物，抑制HIV蛋白酶的化合物，HIV非核苷逆转录酶抑制剂，HIV核苷逆转录酶抑制剂，HIV 核苷酸逆转录酶抑制剂，HIV整合酶抑制剂，gp41抑制剂，CXCR4抑制剂，gp120抑制剂，G6PD和NADH-氧化酶抑制剂，CCR5抑制剂，其他HIV药物或其混合物。

公开(公告)号：KR101551238B1

公开(公告)日：2015-09-09

申请号：KR1020107002073

申请日：2008-06-26

Applicant: 한국화학연구원

Inventor： 구오혼지안 ,  김정은 ,  이일영 ,  미첼마이클엘 ,  로데스게리 ,  손종찬 ,  쉬리안홍

IPC: C07D239/54 ,  C07D401/04 ,  A61K31/506 ,  A61P31/18

CPC classification number: A61K31/513 ,  A61K31/496 ,  A61K31/536 ,  A61K31/551 ,  A61K31/66 ,  A61K31/7048 ,  A61K31/7072 ,  A61K31/708 ,  A61K39/39558 ,  A61K45/06 ,  C07D239/54 ,  C07D239/545 ,  C07D239/553 ,  C07D239/60 ,  C07D401/04 ,  C07D403/04

Abstract: 본발명은하기화학식 I의화합물, 또는그의약학적으로허용가능한염, 용매화물및/또는에스터, 이러한화합물을함유하는조성물, 이러한화합물의투여를포함하는치료방법에관한것이다: [화학식 I]

公开(公告)号：KR1020100041798A

公开(公告)日：2010-04-22

申请号：KR1020107002070

申请日：2008-06-26

Applicant: 한국화학연구원

Inventor： 헤공-신 ,  김정은 ,  미첼마이클엘 ,  쉬리안홍

IPC: C07D239/54 ,  A61K31/513 ,  A61P31/18

CPC classification number: C07D239/54

Abstract: PURPOSE: A compound suppressing HIV(human immunodeficiency virus) reverse transcriptase is provided to treat AIDS by targeting HIV RT of wild type and mutant type HIVs. CONSTITUTION: A compound of chemical formula I or its pharmaceutically acceptable tautomer, salt, solvent compound and/or ester have(has) an activity of suppressing HIV reverse transcriptase. A pharmaceutical composition contains therapeutically effective amount of chemical formula I, or its pharmaceutically acceptable salt, solvent compound and/or ester; and pharmaceutically acceptable carrier or excipient. The pharmaceutical composition additionally contains one or more active drug(has). The active drug is HIV protease inhibitor, HIV non-nucleoside transcriptase inhibitor, HIV nucleoside transcriptase inhibitor, HIV nucleotide reverse transcriptase inhibitor, HIV integrase inhibitor, gp41 inhibitor, CXCR4 inhibitor, gp120 inhibitor, CCR5 inhibitor, CCR8 inhibitor, entry inhibitor, or RNase H inhibitor.

Abstract translation: 目的：通过靶向野生型和突变型HIV的HIV RT，提供抑制HIV（人类免疫缺陷病毒）逆转录酶的化合物来治疗AIDS。 构成：化学式I化合物或其药学上可接受的互变异构体，盐，溶剂化合物和/或酯具有抑制HIV逆转录酶的活性。 药物组合物含有治疗有效量的化学式I或其药学上可接受的盐，溶剂化合物和/或酯; 和药学上可接受的载体或赋形剂。 药物组合物另外含有一种或多种活性药物（已经）。 活性药物是HIV蛋白酶抑制剂，HIV非核苷转录酶抑制剂，HIV核苷转录酶抑制剂，HIV核苷酸逆转录酶抑制剂，HIV整合酶抑制剂，gp41抑制剂，CXCR4抑制剂，gp120抑制剂，CCR5抑制剂，CCR8抑制剂，进入抑制剂或核糖核酸酶 H抑制剂。