公开(公告)号：KR101468209B1

公开(公告)日：2014-12-01

申请号：KR1020130018026

申请日：2013-02-20

Applicant: 한국화학연구원

Inventor： 이기인 ,  피차이아아리갈라 ,  김미리 ,  황인택

IPC: C07D291/04 ,  B01J31/28

Abstract: 본발명은 4차탄소를갖는아민유도체및 구리계촉매를이용한이의제조방법에관한것으로, 본발명에따른시클릭술파미데이트유도체의제조방법은구리계촉매하에서시클릭술파미데이트이민과그리나드시약을반응하여다양한치환기, 특히비치환또는치환된페닐로치환된페닐기가도입된 4차시클릭술파미데이트유도체를종래의어떤방법보다도높은수율로수득할수 있는효과가있으므로, 4차아미노산유도체의전구체로사용되는시클릭술파미데이트유도체의제조에유용할수 있다.

公开(公告)号：KR1020140104173A

公开(公告)日：2014-08-28

申请号：KR1020130018026

申请日：2013-02-20

Applicant: 한국화학연구원

Inventor： 이기인 ,  피차이아아리갈라 ,  김미리 ,  황인택

IPC: C07D291/04 ,  B01J31/28

CPC classification number: C07D291/04 ,  B01J31/28 ,  C07C211/08 ,  C07D285/10 ,  C07D419/04

Abstract: The present invention relates to quaternary carbinamine derivatives and to a method for preparing the same using copper-based catalysts. The method for manufacturing a cyclic sulfamidate derivative, according to the present invention, has an effect of acquiring quaternary cyclic sulfamidate derivatives, with a high yield than any conventional method, in which a phenyl group substituted with various substituents, particularly with unsubstituted or substituted phenyl, by reacting the cyclic sulfamidate imine with Grignard reagent under the copper-based catalysts. Thus, the method can be usefully applied in manufacturing the cyclic sulfamidate derivatives used as a precursor of quaternary amino acid derivatives.

Abstract translation: 本发明涉及季胺衍生物及其使用铜基催化剂的方法。 根据本发明的制备环状磺酰胺酸衍生物的方法具有获得季铵磺酰胺衍生物的效果，其产率高于任何常规方法，其中被各种取代基取代的苯基，特别是与未取代或取代的苯基 ，通过在铜基催化剂下使环磺酰氨基亚胺与格氏试剂反应。 因此，该方法可有效地用于制造用作季氨基酸衍生物前体的环状磺酰胺酸酯衍生物。