-
公开(公告)号：KR101405104B1
公开(公告)日：2014-06-10
申请号：KR1020110142083
申请日：2011-12-26
Applicant: 한남대학교 산학협력단
Abstract: 본 발명은 약물을 포함하는 골 시멘트 매트릭스, 및 양친매성 첨가제(amphiphilic additive)를 포함하는 골 시멘트에 관한 것으로, 본 발명에 따른 양친매성 첨가제가 포함된 약물 함유 골 시멘트는 국소 환부에 적용 시, 골 시멘트에 유의한 물성변화를 야기하지 않을 정도의 양친매성 첨가제를 첨가하여도 골 시멘트 내에 포함된 약물을 국소 환부에 보다 장기적이며 효율적으로 전달할 수 있어 현재까지 임상에서 선택의 여지없이 사용하고 있는, 시술 초기에만 항균효과를 가지는, 기존 약물 포함 골 시멘트를 대체할 수 있는 효과를 가진다.
-
公开(公告)号：KR1020130074171A
公开(公告)日：2013-07-04
申请号：KR1020110142083
申请日：2011-12-26
Applicant: 한남대학교 산학협력단
CPC classification number: A61L24/04 , A61F2/28 , A61L24/0015 , A61L24/0052 , A61L24/0063
Abstract: PURPOSE: A bone cement for having a sustained drug release behavior is provided to resolve a problem of a drug effect not lasting for a predetermined time by allowing a fast initial burst of 10 to 20% of the drug actually included (burst: a concentration of a drug at a localized region being reduced to a treating range or less in time). CONSTITUTION: A bone cement comprises a drug, a bone cement matrix, and an amphiphilic additive. The amphiphilic additive is at least one selected from the group consisting of polyethylene oxide-polypropylene oxide copolymers, polyethylene oxide-polylactic acid copolymer, polyethylene oxide-polylactic acid copolymers, poly (ethylene oxide)-poly lactic glycolic acid copolymers, polyethylene oxide-polycaprolactone copolymers, polyethylene oxides, polyvinyl alcohols, polyoxyethylene alkyl ethers, polyoxyethylene Kester oil derivative, polyoxyethylene sorbitan fatty acid esters, and polyoxyethylene stearates. 0.1 to 40 parts by weight of the amphiphilic additive is included with respect to 100 parts by weight of the bone cement matrix. The drug is at least one selected from antibiotics, anticancer drugs, antimicrobial agents, antiphlogistics, and analgesics. [Reference numerals] (AA) Mix; (BB) Silicone mold; (CC) Drug containing amphiphilic additives/bone cement
Abstract translation: 目的：提供具有持续药物释放行为的骨水泥，通过允许实际包括的药物的10至20％的快速初始爆发来解决不持续预定时间的药物作用的问题（爆发：浓度 在局部区域的药物在时间上减少到治疗范围或更少）。 构成：骨水泥包括药物，骨水泥基质和两亲性添加剂。 两亲性添加剂是选自聚环氧乙烷 - 聚环氧丙烷共聚物，聚环氧乙烷 - 聚乳酸共聚物，聚环氧乙烷 - 聚乳酸共聚物，聚（环氧乙烷） - 聚乳酸乙醇酸共聚物，聚环氧乙烷 - 聚己内酯 共聚物，聚环氧乙烷，聚乙烯醇，聚氧乙烯烷基醚，聚氧乙烯Kester油衍生物，聚氧乙烯山梨糖醇酐脂肪酸酯和聚氧乙烯硬脂酸酯。 相对于100重量份的骨水泥基质，包含0.1〜40重量份的两亲性添加剂。 该药物是选自抗生素，抗癌药，抗微生物剂，消炎药和止痛剂中的至少一种。 （标号）（AA）混合; （BB）硅胶模具; （CC）含有两亲性添加剂/骨水泥的药物
-
Search Results
2
records
(took 0.016 seconds)
