公开(公告)号：KR102007465B1

公开(公告)日：2019-08-05

申请号：KR1020180015942

申请日：2018-02-08

Applicant: 한림대학교 산학협력단

Inventor： 강일준 ,  박미령 ,  이재선

IPC: A23L33/125 ,  A23L29/00 ,  A61K31/7048 ,  A61P3/04

公开(公告)号：KR1020110078941A

公开(公告)日：2011-07-07

申请号：KR1020090135867

申请日：2009-12-31

Applicant: 한림대학교 산학협력단

Inventor： 박진서 ,  주성미 ,  송하용 ,  최수영 ,  강일준 ,  원무호 ,  배영수 ,  이재선 ,  권동주

IPC: A61K36/52 ,  A61K31/70 ,  A61P17/00

CPC classification number: A61K31/7028 ,  A61K36/52 ,  Y10S514/886

Abstract: PURPOSE: A composition containing Juglans mandshurica-derived PGG(1,2,3,4,6-penta-O-galloyl-beta-D-glucose) is provided to treat and prevent inflammatory dermatitis. CONSTITUTION: A composition for treating skin inflammation and injury caused by inflammation-relating molecule(TNF-alpha, IFN-gamma, and TNF-alpha+IFN-gamma) and TPA contains Juglans mandshurica-derived PGG as an active ingredient. A method for preparing the Juglans mandshurica-derived PGG extract comprises: a step of collecting Juglans mandshurica barks, drying and pulverizing; a step of dipping in acetone-water(7:3,v/v) solution and extracting; a step of filtering the extract using Whatman No. 2 filter paper; a step of concentrating and sequentially fractioning with n-hexane, CH_2Cl_2, and EtOAc; and a step of freeze-drying.

Abstract translation: 目的：提供含有胡桃木来源的PGG（1,2,3,4,6-五-O-乙酰基-β-D-葡萄糖）的组合物以治疗和预防炎症性皮炎。 构成：用于治疗由炎症相关分子（TNF-α，IFN-γ和TNF-α+ IFN-γ）和TPA引起的皮肤炎症和损伤的组合物含有胡桃木来源的PGG作为活性成分。 一种制备胡桃木来源的PGG提取物的方法，包括：收集胡桃木树皮，干燥和粉碎的步骤; 浸泡在丙酮 - 水（7：3，v / v）溶液中并提取的步骤; 使用Whatman 2号滤纸过滤提取物的步骤; 浓缩并依次用正己烷，CH 2 Cl 2和EtOAc分级的步骤; 和冷冻干燥步骤。