公开(公告)号：KR1020130083596A

公开(公告)日：2013-07-23

申请号：KR1020120004276

申请日：2012-01-13

Applicant: 한림대학교 산학협력단

Inventor： 전욱 ,  조용석 ,  양은경 ,  김성포 ,  정삼현 ,  주지훈 ,  권미영

IPC: A61K31/728 ,  A61K38/17 ,  A61K47/48 ,  A61P17/02

CPC classification number: A61K31/728 ,  A61K9/0014 ,  A61K9/7007 ,  A61K38/39 ,  A61K47/6953 ,  Y10S514/887

Abstract: PURPOSE: A method for preparing a dermal substitute containing collagen and hyaluronic acid for wound healing and the dermal substitute are provided to effectively substitute dermis with excellent biocompatibility by comprising large and uniform pores and connection paths and to overcome the limit of a conventional two-step surgery through a hyaluronic acid regeneration effect and a moisturizing effect. CONSTITUTION: A method for preparing a dermal substitute for wound healing comprises the steps of: reacting non-antigenic collagen or collagen derivatives with hyaluronic acid and forming a collagen-hyaluronic acid complex by ionic bond; homogenizing the collagen-hyaluronic acid complex and preparing a dispersion; naturally precipitating the dispersion and freeze-drying the collagen-hyaluronic acid complex; and physically or chemically crosslinking the freeze-dried collagen-hyaluronic acid complex.

Abstract translation: 目的：制备含有胶原蛋白和透明质酸用于伤口愈合的真皮替代物的方法，并提供皮肤替代物，以通过包含大而均匀的孔和连接路径来有效地代替具有优异生物相容性的真皮，并克服常规两步骤 手术通过透明质酸再生效果和保湿效果。 构成：用于制备伤口愈合的真皮替代物的方法包括以下步骤：使非抗原性胶原或胶原衍生物与透明质酸反应并通过离子键形成胶原 - 透明质酸络合物; 使胶原蛋白 - 透明质酸络合物匀浆并制备分散体; 自然沉淀分散体并冷冻干燥胶原蛋白 - 透明质酸络合物; 并将物理或化学交联冷冻干燥的胶原 - 透明质酸络合物。