公开(公告)号：KR1020110111950A

公开(公告)日：2011-10-12

申请号：KR1020100031287

申请日：2010-04-06

Applicant: 화인코주식회사

Inventor： 임건빈 ,  최재형 ,  김진철 ,  권택관

IPC: A61K9/28 ,  A61K9/20 ,  A61K47/48

CPC classification number: A61K9/5169 ,  A61K9/0014 ,  A61K9/5192 ,  A61K31/122 ,  A61K31/164

Abstract: 나노 목적물질 전달체 및 이의 제조 방법에 있어서, 피브로인이 코팅된 나노 목적물질 전달체는 내부에 지용성 목적 물질을 봉입한 지질 나노입자와, 지질 나노입자에 코팅된 피브로인 코팅막을 포함한다. 지질 나노입자에 피브로인을 코팅함으로서 형성된 목적물질 전달체는 표면에 양이온 전하의 특성을 갖기 때문에 음의 전하를 가지는 피부와의 접촉시 지용성 목적 물질의 피부 투과성이 보다 향상될 수 있다.

公开(公告)号：KR101048152B1

公开(公告)日：2011-07-11

申请号：KR1020100036287

申请日：2010-04-20

Applicant: 강원대학교산학협력단 ,  화인코주식회사

Inventor： 김진철 ,  임건빈 ,  최재형 ,  이미선 ,  강미경

IPC: A61K9/06 ,  A61K47/40 ,  C08B37/16

CPC classification number: A61K47/6951 ,  A61K9/06 ,  A61K47/42 ,  A61K2121/00

Abstract: PURPOSE: A cyclo dextrin hydrogel containing hydrophobic fibroin and a method for preparing the same are provided to actively release wound healing drug to the outside. CONSTITUTION: A cyclo dextrin hydrogel contains hydrophobic fibroin. The cyclo dextrin hydrogel is prepared by cross-linking cyclo dextrin. The dextrin is selected from alpha-cyclo dextrin, beta-cyclo dextrin, and gamma-cyclo dextrin. The hydrophobic fibroin is fixed inside the cyclo dextrin hydrogel. The hydrophobic fibroin is formed by covalent bond of carbon chains.

Abstract translation: 目的：提供含有疏水性丝心蛋白的环糊精水凝胶及其制备方法，以向外界主动释放伤口愈合药物。 构成：环糊精水凝胶含有疏水性丝心蛋白。 环糊精水凝胶通过交联环糊精制备。 糊精选自α-环糊精，β-环糊精和γ-环糊精。 疏水性丝心蛋白固定在环糊精水凝胶内。 疏水性丝心蛋白由碳链的共价键形成。

公开(公告)号：KR1020120092804A

公开(公告)日：2012-08-22

申请号：KR1020110012653

申请日：2011-02-14

Applicant: 화인코주식회사

Inventor： 임건빈 ,  김진철 ,  최재형 ,  권택관 ,  서희진

IPC: A61K47/30 ,  A61K47/48 ,  A61K9/16 ,  A61P35/00

CPC classification number: A61K47/30 ,  A61K9/16 ,  Y10S514/885

Abstract: PURPOSE: A monoolein cubic phase on which alginate and silk fibroin are fixed is provided to release less target ingredients at low pH and release target ingredient a lot of target ingredients. CONSTITUTION: A monoolein cubic phase contains anionic natural polymers containing alginate and amphoteric natural polymers containing silk fibroin which are fixed on an aqueous channel thereinside. The alginate and silk fibroin are conjugated by a hydrophobic anchor. The hydrophobic anchor includes monoalakyl acrylate, dialkyl acrylate, palmitic acid, stearyl amine, or stearic acid. A method for preparing the monoolein cubic phase comprises: a step of mixing the silk fibroin and target materials to prepare a mixture solution; and a step of adding the mixture solution to a monoolein melt solution to form transparent gel.

Abstract translation: 目的：提供固定藻酸盐和丝素蛋白的单油酸酯立方相，以在低pH下释放较少的目标成分，并释放目标成分大量的目标成分。 构成：单油酸酯立方相含有含有藻酸盐和含有丝心蛋白的两性天然聚合物的阴离子天然聚合物，其固定在其内部的水性通道上。 藻酸盐和丝素蛋白通过疏水锚结合。 疏水性锚定剂包括丙烯酸单烷基酯，丙烯酸二烷基酯，棕榈酸，硬脂胺或硬脂酸。 制备单油酸酯立方相的方法包括：将丝素蛋白与目标物质混合以制备混合溶液的步骤; 以及将混合溶液加入到单油酸酯熔融溶液中以形成透明凝胶的步骤。