公开(公告)号：KR100989389B1

公开(公告)日：2010-10-25

申请号：KR1020100056668

申请日：2010-06-15

Applicant: 화일약품주식회사

Inventor： 정용호 ,  정춘원 ,  이중우 ,  이윤승 ,  김경철 ,  강병규

IPC: C07D417/04 ,  C07D403/06 ,  A61K31/497 ,  A61P25/18

Abstract: PURPOSE: A ziprasidone hydrochloride 1.5 hydrate with novel crystal and a method for preparing the same are provided to ensure 99.5% or more of crystal purity and high stability. CONSTITUTION: A method for preparing crystalline ziprasidone hydrochloride 1.5 hydrate comprises: a step of recrystalizing ziprasidone base in a solvent containing 1-methyl-2-pyrrolidone or dimethylsulfoxide; a step of adding t-butylmethyl ether, buthylmethyl ether and sec-butylmethyl ether or mixture thereof to prepare slurry; and a step of obtaining crystalline ziprasidone hydrochloride 1.5 hydrate.

Abstract translation: 目的：提供具有新晶体的齐拉西酮盐酸盐1.5水合物及其制备方法，以确保99.5％以上的晶体纯度和高稳定性。 结构：制备结晶齐拉昔酮盐酸盐1.5水合物的方法包括：在含1-甲基-2-吡咯烷酮或二甲基亚砜的溶剂中重结晶齐拉西酮碱的步骤; 加入叔丁基甲基醚，丁基甲基醚和仲丁基甲基醚或其混合物以制备浆料的步骤; 和获得结晶的齐拉昔酮盐酸盐1.5水合物的步骤。