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公开(公告)号：WO2013141575A1
公开(公告)日：2013-09-26
申请号：PCT/KR2013/002246
申请日：2013-03-19
Applicant: 황재효
IPC: A61K31/4375 , A61P11/06
CPC classification number: A61K31/439
Abstract: 본 발명은 6,7-디-O-아세틸시노코큘린 (6,7-di-O-acetylsinococuline) 또는 이의 약리학적으로 허용가능한 염을 유효성분으로 포함하는 천식 예방 또는 치료용 조성물에 관한 것으로, 보다 구체적으로 6,7-디-O-아세틸시노코큘린은 기도 점막조직에 염증을 일으키는 림프구 (lymphocytes), 중성구 (neutrophils), 또는 호산구 (eosinophils) 등의 염증 세포의 기관지 폐포로의 유입을 방지하고, 기도 과민성을 억제하고, 기관지 주위에 침윤하는 염증세포의 침윤을 감소시키며, 내강 내에 점액 분비 및 점막세포 비후 등을 억제하여 천식치료에 효과적이므로, 이를 천식 예방 또는 치료용 약학 조성물 및 건강식품 조성물로 활용한다.
Abstract translation: 本发明涉及用于预防或治疗哮喘的组合物，其包含作为活性成分的6,7-二-O-乙酰酪氨酸或其药理学上可接受的盐。 更具体地，6,7-二-O-乙酰基聚肠氨酸可防止可能引起气道粘膜组织炎症的炎症细胞，例如淋巴细胞，嗜中性粒细胞，嗜酸性粒细胞等，进入支气管肺泡空间，抑制过敏反应 气道减少渗透到支气管周围的炎症细胞的浸润，并抑制内腔中的粘液分泌，粘膜细胞增厚等。 因此，6,7-二-O-乙酰酪氨酸可有效治疗哮喘，因此可用于预防或治疗哮喘和保健食品组合物的药物组合物中。
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公开(公告)号：KR1020130106130A
公开(公告)日：2013-09-27
申请号：KR1020120027791
申请日：2012-03-19
Applicant: 황재효
Abstract: PURPOSE: A composition for preventing or treating asthma is provided to show an antioxidative effect and to suppress NO generation, iNOS expression, edema, inflammatory cell invasion, and myeloperoxidase activation using a Dianthi herba extract, thereby showing a superior anti-inflammation effect. CONSTITUTION: A composition for preventing or treating inflammatory diseases contains a Dianthi herba extract as an active ingredient. The extract is extracted by mixing 1 part by weight of Dianthi herba with 5-30 parts by weight of 60-80 % ethanol solution. A pharmaceutical composition for preventing or treating inflammatory diseases contains the extract as an active ingredient. A cosmetic composition for preventing or treating inflammatory diseases contains the extract as an active ingredient.
Abstract translation: 目的：提供一种用于预防或治疗哮喘的组合物，以显示出抗氧化作用，并使用狄氏ba提取物抑制NO产生，iNOS表达，水肿，炎性细胞侵袭和髓过氧化物酶活化，从而显示出优异的抗炎作用。 构成：用于预防或治疗炎性疾病的组合物含有作为活性成分的天hi草提取物。 通过将1重量份的Dianthi herba与5-30重量份的60-80％乙醇溶液混合来提取提取物。 用于预防或治疗炎性疾病的药物组合物含有提取物作为活性成分。 用于预防或治疗炎性疾病的化妆品组合物含有提取物作为活性成分。
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公开(公告)号：KR1020130106129A
公开(公告)日：2013-09-27
申请号：KR1020120027790
申请日：2012-03-19
Applicant: 황재효
IPC: A61K31/4375 , A61P11/06
CPC classification number: A61K31/439
Abstract: PURPOSE: A composition for preventing or treating asthma is provided to suppress inflammatory cells and hypersensitivity of airway, to reduce inflammatory cell invasion around bronchus, and to suppress mucus secretion and mucosal thickening, thereby effectively treating and preventing asthma. CONSTITUTION: A composition for preventing or treating asthma contains 6,7-di-O-acetylsinococuline or a pharmacologically acceptable salt thereof as an active ingredient. 6,7-di-O-acetylsinococuline or a pharmacologically acceptable salt thereof suppresses inflammatory cells such as lymphocytes, neutrophils, and eosinophils. A pharmaceutical composition for preventing or treating asthma contains 6,7-di-O-acetylsinococuline or a pharmacologically acceptable salt thereof as an active ingredient. A health food composition for preventing or treating asthma contains 6,7-di-O-acetylsinococuline or a pharmacologically acceptable salt thereof as an active ingredient.
Abstract translation: 目的：提供一种预防或治疗哮喘的组合物，以抑制炎症细胞和气道超敏反应，减少支气管附近的炎症细胞侵袭，抑制粘液分泌和粘膜增厚，从而有效治疗和预防哮喘。 构成：用于预防或治疗哮喘的组合物含有作为活性成分的6,7-二-O-乙酰酪氨酸或其药理学上可接受的盐。 6,7-二-O-乙酰酪氨酸或其药理学上可接受的盐抑制炎性细胞如淋巴细胞，嗜中性粒细胞和嗜酸性粒细胞。 用于预防或治疗哮喘的药物组合物含有作为活性成分的6,7-二-O-乙酰酪氨酸或其药理学上可接受的盐。 用于预防或治疗哮喘的健康食品组合物含有6,7-二-O-乙酰基胆固醇或其药理学上可接受的盐作为活性成分。
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