公开(公告)号：US20220194935A1

公开(公告)日：2022-06-23

申请号：US17594617

申请日：2020-06-03

Applicant: 3M INNOVATIVE PROPERTIES COMPANY

Inventor： George W. Griesgraber ,  Hannah C. Cohen ,  Devon M. Hunerdosse ,  Kevin J. Bechtold

IPC: C07D471/04

Abstract: Imidazo[4,5-c]quinoline compounds having a substituent that is attached at the N-1 position by a branched group, single enantiomers of the compounds, pharmaceutical compositions containing the compounds, and methods of making the compounds are disclosed. Methods of use of the compounds as immune response modifiers, for inducing cytokine biosynthesis in humans and animals, and in the treatment of diseases including infectious and neoplastic diseases are also disclosed.

公开(公告)号：US20230406855A1

公开(公告)日：2023-12-21

申请号：US18251578

申请日：2021-10-15

Applicant: 3M INNOVATIVE PROPERTIES COMPANY

Inventor： George W. Griesgraber ,  Mark A. Tomai ,  Hannah C. Cohen ,  Devon M. Hunerdosse

IPC: C07D471/04 ,  A61K47/54

CPC classification number: C07D471/04 ,  A61K47/545

Abstract: Imidazoquinoline compounds, salts thereof, conjugates thereof, pharmaceutical compositions containing the compounds and conjugates, and methods of use of such compounds as immune response modifiers, for inducing cytokine biosynthesis in humans and animals.

公开(公告)号：US20230263462A1

公开(公告)日：2023-08-24

申请号：US18009056

申请日：2021-05-25

Applicant: 3M INNOVATIVE PROPERTIES COMPANY

Inventor： Stephen M. Kennedy ,  Jacob E. Odom ,  Jeffrey P. Kalish ,  Sean M. Sweetnam ,  Michael D. Benson ,  Jana Ninkovic ,  Devon M. Hunerdosse ,  Jason W. Bjork

IPC: A61B5/00 ,  A61B5/0531

CPC classification number: A61B5/445 ,  A61B5/0531 ,  A61B5/6801

Abstract: A method and system for tissue impedance measurement are disclosed. In examples, the system comprises electrical contacts configured to be coupled to a first tissue and a first device configured to apply a first electrical signal to the first tissue via the electrical contacts. The system further comprises a second device configured to determine a first impedance phase angle of epithelial tissue of the first tissue site based on the first applied electrical signal, determine a baseline impedance phase angle of epithelial tissue corresponding to a second tissue, determine information indicative of epithelial tissue characteristics based on a ratio of the first impedance phase angle and the baseline impedance phase angle, and output information indicative of the epithelial tissue characteristics.

公开(公告)号：US20220177471A1

公开(公告)日：2022-06-09

申请号：US17594415

申请日：2020-05-27

Applicant: 3M INNOVATIVE PROPERTIES COMPANY

Inventor： George W. Griesgraber ,  Michael J. Rice ,  Hannah C. Cohen ,  Devon M. Hunerdosse ,  Adam D. Miller ,  Joshua R. Wurst

IPC: C07D471/04

Abstract: Imidazo[4,5-c]quinoline compounds having a substituent that is attached at the N-1 position by a branched group, single enantiomers of the compounds, pharmaceutical compositions containing the compounds, and methods of making the compounds are disclosed. Methods of use of the compounds as immune response modifiers, for inducing (or inhibiting) cytokine biosynthesis in humans and animals, and in the treatment of diseases including infectious and neoplastic diseases are also disclosed.