公开(公告)号：US20180244669A1

公开(公告)日：2018-08-30

申请号：US15753573

申请日：2016-08-26

Applicant: 3M INNOVATIVE PROPERTIES COMPANY

Inventor： GEORGE W. GRIESGRABER

IPC: C07D471/04

CPC classification number: C07D471/04

Abstract: Imidazo[4,5-c] ring compounds, (particularly imidzao[4,5-c]quinolines, 6,7,8,9-tetrahydroimidazo[4,5-c]quinolines, imidazo[4,5-c]naphthyridines, and 6,7,8,9-tetrahydroimidazo[4,5-c]naphthyridine compounds) having a substituted guanidine substituent at the 1-position, pharmaceutical compositions containing the compounds, and methods of making the compounds are disclosed. Methods of use of the compounds as immune response modifiers, for inducing cytokine biosynthesis in animals and in the treatment of diseases including viral and neoplastic diseases are also disclosed.

公开(公告)号：US20180305357A1

公开(公告)日：2018-10-25

申请号：US16016933

申请日：2018-06-25

Applicant: 3M INNOVATIVE PROPERTIES COMPANY

Inventor： DORIS STOERMER ,  GEORGE W. GRIESGRABER ,  TUSHAR A. KSHIRSAGAR

IPC: C07D471/04 ,  A61K47/66 ,  A61K47/68

CPC classification number: C07D471/04 ,  A01K13/002 ,  A01K13/003 ,  A46B11/0013 ,  A46B11/0055 ,  A46B11/0062 ,  A46B11/0079 ,  A46B2200/104 ,  A61K31/437 ,  A61K47/556 ,  A61K47/66 ,  A61K47/68 ,  A61K47/6801 ,  C07D513/04

Abstract: The present invention provides an immune response modifier (IRM) composition that includes an IRM moiety and a second active moiety covalently linked to the IRM moiety, wherein the covalent link comprises a labile bond directly attached to the IRM moiety.

公开(公告)号：US20190336409A1

公开(公告)日：2019-11-07

申请号：US16475260

申请日：2018-01-02

Applicant: 3M INNOVATIVE PROPERTIES COMPANY

Inventor： RANJANI V. PARTHASARATHY ,  RAMESH C. KUMAR ,  MATTHEW T. SCHOLZ ,  STEVEN P. SWANSON ,  ANDREW W. VAIL ,  JERALD K. RASMUSSEN ,  GEORGE W. GRIESGRABER ,  CATHERINE D. HEAPY

IPC: A61K8/02 ,  A61Q17/00 ,  A61K8/81 ,  A61K8/34 ,  A61K8/84 ,  A01N47/44 ,  A01N31/02 ,  A01N25/10 ,  A61L2/00

Abstract: Disclosed herein are methods that include contacting a skin surface with a first liquid composition; and then contacting in the skin surface with a cationic coated article loaded with a second liquid composition, while at least some portion of the first liquid composition remains on the skin surface, wherein one or both of the first liquid composition or the second liquid composition includes acrylate copolymer particles dispersed therein, the acrylate copolymer particles including the reaction product of a reaction mixture, the reaction mixture including monomers, the monomers including from about 5 wt % to about 50 wt % of at least one high Tg monomer where the wt % of the high Tg monomer is with respect to the total weight of the monomers in the reaction mixture; and from about 20 wt % to about 80 wt % of at least one low Tg monomer where the wt % of the low Tg monomer is with respect to the total weight of the monomers in the reaction mixture, wherein the particles have a number average diameter of at least about 100 nm and wherein at least one and only one of the first or the second composition comprises greater than or equal to 60 wt % of at least one alcohol.

公开(公告)号：US20190105416A1

公开(公告)日：2019-04-11

申请号：US16096776

申请日：2017-04-25

Applicant: 3M INNOVATIVE PROPERTIES COMPANY

Inventor： NAIYONG JING ,  RYAN T. WOLDT ,  WENSHENG XIA ,  KEVIN D. LANDGREBE ,  TIMOTHY J. NIES ,  BRYAN A. BAKER ,  SEMRA COLAK ATAN ,  GARY W. JORGENSEN ,  GIUSEPPE M. BOMMARITO ,  DAVID P. SWANSON ,  GEORGE W. GRIESGRABER ,  RANJANI V. PARTHASARATHY

IPC: A61L2/18 ,  A61L2/28 ,  C12Q1/22

Abstract: A method of disinfecting a medical device comprises three steps. First, a disinfectant is contacted with a process indicator and the medical device. The disinfectant comprises at least one aldehyde. The process indicator contains a synthetic amine-containing compound disposed on a substrate. The synthetic amine-containing compound comprises at least one of primary amino groups or secondary amino groups, and is reactive with the disinfectant to form at least one adduct. The synthetic amine-containing compound and the medical device are in fluid communication through the disinfectant. A predetermined disinfectant exposure criterion exists for contacting the disinfectant with the medical device. Second, the process indicator is spectrally observed and at least one parameter is obtained therefrom that is predictive of the predetermined disinfectant exposure criterion. The third step is determining that the predetermined disinfectant exposure criterion has been achieved.

公开(公告)号：US20190055241A1

公开(公告)日：2019-02-21

申请号：US16166355

申请日：2018-10-22

Applicant: 3M INNOVATIVE PROPERTIES COMPANY

Inventor： GEORGE W. GRIESGRABER

IPC: C07D471/04 ,  C07D471/14 ,  A61K31/437

Abstract: Imidazo[4,5-c] ring compounds, (particularly imidzao[4,5-c]quinolines, 6,7,8,9-tetrahydroimidazo[4,5-c]quinolines, imidazo[4,5-c]naphthyridines, and 6,7,8,9-tetrahydroimidazo[4,5-c]naphthyridine compounds) having a guanidine substituent at the 1-position, pharmaceutical compositions containing the compounds, and methods of making the compounds are disclosed. Methods of use of the compounds as immune response modifiers, for inducing cytokine biosynthesis in animals and in the treatment of diseases including viral and neoplastic diseases are also disclosed.

公开(公告)号：US20180237435A1

公开(公告)日：2018-08-23

申请号：US15753560

申请日：2016-08-26

Applicant: 3M INNOVATIVE PROPERTIES COMPANY

Inventor： GEORGE W. GRIESGRABER

IPC: C07D471/04 ,  C07D471/14

CPC classification number: C07D471/04 ,  A61K31/437 ,  C07D471/14

Abstract: Imidazo[4,5-c] ring compounds, (particularly imidazo[4,5-c]quinolines, 6,7,8,9-tetrahydroimidazo[4,5-c]quinolines, imidazo[4,5-c]naphthyridines, and 6,7,8,9-tetrahydroimidazo[4,5-c]naphthyridine compounds) having a guanidine substituent at the 1-position, pharmaceutical compositions containing the compounds, and methods of making the compounds are disclosed. Methods of use of the compounds as immune response modifiers, for inducing cytokine biosynthesis in animals and in the treatment of diseases including viral and neoplastic diseases are also disclosed.