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公开(公告)号:WO2021250494A1
公开(公告)日:2021-12-16
申请号:PCT/IB2021/054553
申请日:2021-05-25
Applicant: 3M INNOVATIVE PROPERTIES COMPANY
Inventor: KENNEDY, Stephen M. , ODOM, Jacob E. , KALISH, Jeffrey P. , SWEETNAM, Sean M. , BENSON, Michael D. , NINKOVIC, Jana , HUNERDOSSE, Devon M. , BJORK, Jason W.
IPC: A61B5/0531 , A61B5/00 , A61B2560/0468 , A61B5/445 , A61B5/683 , A61B5/7275
Abstract: A method and system for tissue impedance measurement are disclosed. In examples, the system comprises electrical contacts configured to be coupled to a first tissue and a first device configured to apply a first electrical signal to the first tissue via the electrical contacts. The system further comprises a second device configured to determine a first impedance phase angle of epithelial tissue of the first tissue site based on the first applied electrical signal, determine a baseline impedance phase angle of epithelial tissue corresponding to a second tissue, determine information indicative of epithelial tissue characteristics based on a ratio of the first impedance phase angle and the baseline impedance phase angle, and output information indicative of the epithelial tissue characteristics.
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2.
公开(公告)号:WO2020245706A1
公开(公告)日:2020-12-10
申请号:PCT/IB2020/055034
申请日:2020-05-27
Applicant: 3M INNOVATIVE PROPERTIES COMPANY
Inventor: GRIESGRABER, George W. , RICE, Michael J. , COHEN, Hannah C. , HUNERDOSSE, Devon M. , MILLER, Adam D. , WURST, Joshua R.
IPC: C07D471/04 , A61P31/12 , A61K31/437
Abstract: Imidazo[4,5-c]quinoline compounds having a substituent that is attached at the N-1 position by a branched group, single enantiomers of the compounds, pharmaceutical compositions containing the compounds, and methods of making the compounds are disclosed. Methods of use of the compounds as immune response modifiers, for inducing (or inhibiting) cytokine biosynthesis in humans and animals, and in the treatment of diseases including infectious and neoplastic diseases are also disclosed.
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公开(公告)号:WO2022130046A1
公开(公告)日:2022-06-23
申请号:PCT/IB2021/059522
申请日:2021-10-15
Applicant: 3M INNOVATIVE PROPERTIES COMPANY
Inventor: GRIESGRABER, George W. , TOMAI, Mark A. , COHEN, Hannah C. , HUNERDOSSE, Devon M.
IPC: C07D471/04 , A61P31/12 , A61K31/437
Abstract: Imidazoquinoline compounds, salts thereof, conjugates thereof, pharmaceutical compositions containing the compounds and conjugates, and methods of use of such compounds as immune response modifiers, for inducing cytokine biosynthesis in humans and animals.
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公开(公告)号:WO2020250089A1
公开(公告)日:2020-12-17
申请号:PCT/IB2020/055235
申请日:2020-06-03
Applicant: 3M INNOVATIVE PROPERTIES COMPANY
Inventor: GRIESGRABER, George W. , COHEN, Hannah C. , HUNERDOSSE, Devon M. , BECHTOLD, Kevin J.
IPC: C07D471/04 , A61K31/47 , A61P35/00 , A61P37/02
Abstract: Imidazo[4,5-c]quinoline compounds having a substituent that is attached at the N-1 position by a branched group, single enantiomers of the compounds, pharmaceutical compositions containing the compounds, and methods of making the compounds are disclosed. Methods of use of the compounds as immune response modifiers, for inducing cytokine biosynthesis in humans and animals, and in the treatment of diseases including infectious and neoplastic diseases are also disclosed.
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公开(公告)号:EP4263537A1
公开(公告)日:2023-10-25
申请号:EP21802428.9
申请日:2021-10-15
Applicant: 3M Innovative Properties Company
Inventor: GRIESGRABER, George W. , TOMAI, Mark A. , COHEN, Hannah C. , HUNERDOSSE, Devon M.
IPC: C07D471/04 , A61P31/12 , A61K31/437
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公开(公告)号:EP3983408A1
公开(公告)日:2022-04-20
申请号:EP20731969.0
申请日:2020-06-03
Applicant: 3M Innovative Properties Company
Inventor: GRIESGRABER, George W. , COHEN, Hannah C. , HUNERDOSSE, Devon M. , BECHTOLD, Kevin J.
IPC: C07D471/04 , A61K31/47 , A61P35/00 , A61P37/02
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7.
公开(公告)号:EP3980415A1
公开(公告)日:2022-04-13
申请号:EP20729836.5
申请日:2020-05-27
Applicant: 3M Innovative Properties Company
Inventor: GRIESGRABER, George W. , RICE, Michael J. , COHEN, Hannah C. , HUNERDOSSE, Devon M. , MILLER, Adam D. , WURST, Joshua R.
IPC: C07D471/04 , A61P31/12 , A61K31/437
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公开(公告)号:EP4164480A1
公开(公告)日:2023-04-19
申请号:EP21729029.5
申请日:2021-05-25
Applicant: 3M Innovative Properties Company
Inventor: KENNEDY, Stephen M. , ODOM, Jacob E. , KALISH, Jeffrey P. , SWEETNAM, Sean M. , BENSON, Michael D. , NINKOVIC, Jana , HUNERDOSSE, Devon M. , BJORK, Jason W.
IPC: A61B5/0531 , A61B5/00
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