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公开(公告)号：WO2019234661A1
公开(公告)日：2019-12-12
申请号：PCT/IB2019/054690
申请日：2019-06-05
Applicant: 3M INNOVATIVE PROPERTIES COMPANY
Inventor： CHRISTENSEN, Randilynn B. , BUDD, Kenton D. , FALSAFI, Afshin , AKSIT, Mahmut , NINKOVIC, Jana , LIU, Jie J. , AGRE, Mark B. , NAKAMURA, Masayuki , BJORK, Jason W. , CRAIG, Bradley D. , RUSIN, Richard P. , HOMNICK, Paul J. , OXMAN, Joel D. , WANG, Yizhong , KLAIBER, Paul R.
IPC: A61C5/64 , A61C5/68 , A61K6/00 , A61K6/02 , A61K6/027 , A61K6/06 , A61K6/083 , B01F13/00 , B05C17/005
Abstract: A hardenable (e.g. dental) compositions is described comprising an encapsulated material. The encapsulated material comprises a basic core material and an inorganic shell material having certain viscosity criteria. Also described are dispensing devices and kits are described comprising a hardenable (e.g. dental) composition comprising a liquid material and an encapsulated material wherein the encapsulated material comprises a basic core material and an inorganic shell material comprising a metal oxide surrounding the core. The dispensing devices and kits can facilitate the methods of applying the hardneable composition. The hardenable or hardened (e.g. cured) composition can provide various technical effects such as a delayed release of a basic core material, a delayed increase in basicity, promoting remineralization of a tooth or bone structure, and increasing the average alkaline phosphatase (ALP) activity of pulp cells. In some embodiments, the composition is a dental (e.g. sealant) composition for application to a tooth structure.
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公开(公告)号：WO2019234633A1
公开(公告)日：2019-12-12
申请号：PCT/IB2019/054644
申请日：2019-06-04
Applicant: 3M INNOVATIVE PROPERTIES COMPANY
Inventor： CHRISTENSEN, Randilynn B. , BUDD, Kenton D. , FALSAFI, Afshin , AKSIT, Mahmut , NINKOVIC, Jana , LIU, Jie J. , AGRE, Mark B. , NAKAMURA, Masayuki , BJORK, Jason W. , CRAIG, Bradley D. , RUSIN, Richard P. , HOMNICK, Paul J. , OXMAN, Joel D. , WANG, Yizhong , KLAIBER, Paul R. , DODGE, Bill H.
Abstract: A method of applying a two-part dental sealant is described comprising providing a syringe device (1) comprising a cartridge (10) including first and second chamber. The first chamber contains a first part of a dental sealant comprising a (meth)acrylate resin and an oxidizing curing agent. The second chamber contains a second part of a dental sealant comprising a (meth)acrylate resin and a reducing curing agent that reacts with the oxidizing curing agent of the first chamber. The first and/or second part of the dental sealant further comprise a single component or multiple components that neutralize acid and promote remineralization. The syringe device comprises a dispensing nozzle (17) comprising a static mixer and an outlet at one end of the cartridge and a plunger (20) at the opposing end of the cartridge. Also described is a kit for storing and applying the dental sealant is described.
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公开(公告)号：WO2018067532A1
公开(公告)日：2018-04-12
申请号：PCT/US2017/054892
申请日：2017-10-03
Applicant: 3M INNOVATIVE PROPERTIES COMPANY
Inventor： O'HARE, Jonathan J. , PEKUROVSKY, Mikhail L. , DETERMAN, Amy S. , PITERA, Gino L. , BJORK, Jason W. , NORTON, Daniel V. , ASMUS, Robert A.
Abstract: A method of forming a fibrin hydrogel composition including providing one or more unitary masses of a fibrin hydrogel, dividing at least one of the unitary masses of the fibrin hydrogel into a multiplicity of smaller pieces of the fibrin hydrogel, and recombining at least a portion of the smaller pieces into a cohesive mass. Dividing at least one of the unitary masses of fibrin hydrogel into a multiplicity of smaller pieces may include shearing or cutting the unitary masses to form an aqueous dispersion of the fibrin hydrogel in an aqueous medium. The aqueous dispersion of fibrin hydrogel may be applied to a substrate on a roller or an endless belt, and is optionally overlaid by a scrim. The cohesive mass of fibrin hydrogel, which may be formed by removing at least a portion of the aqueous medium from the aqueous dispersion of the smaller pieces of the fibrin hydrogel, finds uses in wound dressing articles.
Abstract translation: 一种形成纤维蛋白水凝胶组合物的方法，包括提供一个或多个纤维蛋白水凝胶的单一团块，将纤维蛋白水凝胶的单一团块中的至少一个分成多个纤维蛋白水凝胶的较小片段 并且将至少一部分小块重新组合成粘性物质。 将至少一个单一纤维蛋白水凝胶块分成多个小块可包括剪切或切割整体块以形成纤维蛋白水凝胶在水性介质中的水分散体。 纤维蛋白水凝胶的水分散体可以施加到辊或环形带上的基底上，并且任选地被稀松布覆盖。 可以通过从纤维蛋白水凝胶的较小部分的水分散体中除去至少一部分水性介质而形成的纤维蛋白水凝胶的粘着块可用于伤口敷料制品。
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公开(公告)号：WO2021250494A1
公开(公告)日：2021-12-16
申请号：PCT/IB2021/054553
申请日：2021-05-25
Applicant: 3M INNOVATIVE PROPERTIES COMPANY
Inventor： KENNEDY, Stephen M. , ODOM, Jacob E. , KALISH, Jeffrey P. , SWEETNAM, Sean M. , BENSON, Michael D. , NINKOVIC, Jana , HUNERDOSSE, Devon M. , BJORK, Jason W.
IPC: A61B5/0531 , A61B5/00 , A61B2560/0468 , A61B5/445 , A61B5/683 , A61B5/7275
Abstract: A method and system for tissue impedance measurement are disclosed. In examples, the system comprises electrical contacts configured to be coupled to a first tissue and a first device configured to apply a first electrical signal to the first tissue via the electrical contacts. The system further comprises a second device configured to determine a first impedance phase angle of epithelial tissue of the first tissue site based on the first applied electrical signal, determine a baseline impedance phase angle of epithelial tissue corresponding to a second tissue, determine information indicative of epithelial tissue characteristics based on a ratio of the first impedance phase angle and the baseline impedance phase angle, and output information indicative of the epithelial tissue characteristics.
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公开(公告)号：WO2016160541A1
公开(公告)日：2016-10-06
申请号：PCT/US2016/024141
申请日：2016-03-25
Applicant: 3M INNOVATIVE PROPERTIES COMPANY
Inventor： BJORK, Jason W. , YOUNG, Alexi J. , BEEN, Raha A. , NINKOVIC, Jana , BAKER, Bryan A.
IPC: A61L24/10
CPC classification number: A61L26/008 , A61F13/0259 , A61F2013/00089 , A61F2013/00655 , A61F2013/00676 , A61F2013/00706 , A61L24/106 , A61L26/0042 , A61L26/0071
Abstract: A method of forming a fibrin hydrogel composition is described. The method comprises forming an aqueous solution comprising fibrinogen, fibrin-forming enzyme, and a fibrin hydrogel forming salt. The fibrin hydrogel forming salt concentration is greater than or equal to the threshold concentration to form a fibrin hydrogel. The method further comprises reducing the salt concentration below the threshold concentration to form a fibrin hydrogel. In some embodiments, the aqueous solution further comprises a plasticizer. A fibrin composition is also described comprising a fibrin hydrogel having a fibrin concentration ranging from 0.1 to 10 wt-%; and a fibrin hydrogel forming salt. The fibrin hydrogel forming salt has a concentration less than a threshold concentration to form the fibrin hydrogel. The fibrin hydrogel or dehydrated fibrin hydrogel can be in various physical forms such a sheet, foam, or plurality of pieces. Also described are methods of forming a fibrin article, wound dressings and a method of treatment of a wound.
Abstract translation: 描述了形成纤维蛋白水凝胶组合物的方法。 该方法包括形成包含纤维蛋白原，纤维蛋白形成酶和纤维蛋白水凝胶形成盐的水溶液。 纤维蛋白水凝胶形成盐浓度大于或等于阈值浓度以形成纤维蛋白水凝胶。 该方法还包括将盐浓度降低到阈值浓度以下以形成纤维蛋白水凝胶。 在一些实施方案中，水溶液还包含增塑剂。 还描述了纤维蛋白组合物，其包含纤维蛋白浓度范围为0.1至10重量％的纤维蛋白水凝胶; 和纤维蛋白水凝胶形成盐。 纤维蛋白水凝胶形成盐的浓度小于阈值浓度以形成纤维蛋白水凝胶。 纤维蛋白水凝胶或脱水纤维蛋白水凝胶可以是各种物理形式，例如片，泡沫或多个片。 还描述了形成纤维蛋白制品，伤口敷料和伤口治疗方法的方法。
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Patent Agency Ranking6.发明申请SYSTEM AND METHOD FOR LIQUID CULTURE OF ANAEROBIC OR MICROAEROPHILIC MICROORGANISMS 审中-公开无机或微生物微生物液体培养系统与方法
公开(公告)号：WO2015175611A1
公开(公告)日：2015-11-19
申请号：PCT/US2015/030491
申请日：2015-05-13
Applicant: 3M INNOVATIVE PROPERTIES COMPANY
Inventor： BJORK, Jason W. , STANENAS, Adam J. , XIA, Wensheng
Abstract: A culture system for culturing a microaerophilic or an anaerobic microorganism is provided. The culture system can include effective amounts of i) an enzyme of an oxidoreductase family and ii) a substrate for said enzyme, a container, and a predetermined volume of aqueous medium that supports growth of said anaerobic or microaerophilic microorganism. The enzyme can be selected from a group consisting of ascorbic acid oxidase and laccase. The effective amounts are effective to deplete dissolved oxygen in the predetermined volume to a concentration that facilitates growth of a microaerophilic microorganism or an obligately-anaerobic microorganism. A method of using the system is also provided.
Abstract translation: 提供了用于培养微嗜酸或厌氧微生物的培养系统。 培养系统可以包括有效量的i）氧化还原酶家族的酶，和ii）所述酶，容器和支持所述厌氧微生物微生物生长的预定体积的水性介质的底物。 酶可以选自抗坏血酸氧化酶和漆酶组。 有效量有效地将预定体积中的溶解氧消耗至促进微生物微生物或专一性厌氧微生物生长的浓度。 还提供了一种使用该系统的方法。
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7.发明申请
公开(公告)号：WO2018102484A1
公开(公告)日：2018-06-07
申请号：PCT/US2017/063829
申请日：2017-11-30
Applicant: 3M INNOVATIVE PROPERTIES COMPANY
Inventor： CHRISTENSEN, Randilynn B. , BUDD, Kenton D. , FALSAFI, Afshin , AKSIT, Mahmut , NINKOVIC, Jana , LIU, Jie J. , AGRE, Mark B. , NAKAMURA, Masayuki , BJORK, Jason W.
Abstract: A (e.g. hardenable dental) composition is described comprising (e.g. a first part comprising) an encapsulated material wherein the encapsulated material comprises a basic core material and an inorganic shell material comprising a metal oxide surrounding the core; and (e.g. a second part comprising) water or an acidic component. Also described is an encapsulated material (e.g. suitable for use in a biological carrier material) comprising a basic core material and an inorganic shell material comprising a metal oxide surrounding the core.
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8.发明申请FIBRIN COMPOSITION COMPRISING CARRIER MATERIAL, METHOD AND WOUND ARTICLES 审中-公开包含载体材料的纤维蛋白组合物，方法和伤口制品
公开(公告)号：WO2018067628A1
公开(公告)日：2018-04-12
申请号：PCT/US2017/055022
申请日：2017-10-04
Applicant: 3M INNOVATIVE PROPERTIES COMPANY
Inventor： BJORK, Jason W. , DETERMAN, Amy S. , O'HARE, Jonathan J. , ASMUS, Robert A. , DIZIO, James P. , TIAN, Zhicheng
Abstract: Provided is a method of forming a fibrin hydrogel composition, the method including providing a fibrin hydrogel or precursor thereof, comprising fibrin hydrogel forming salt. The fibrin hydrogel forming salt concentration is greater than or equal to the threshold concentration to form a fibrin hydrogel. The method further includes combining the fibrin hydrogel with a carrier material. The concentration of the carrier material typically ranges from 0.1 to about 50 wt.-%. The method further includes reducing the salt concentration below the threshold concentration to form a fibrin hydrogel.
Abstract translation: 提供形成纤维蛋白水凝胶组合物的方法，所述方法包括提供包含纤维蛋白水凝胶形成盐的纤维蛋白水凝胶或其前体。 形成纤维蛋白水凝胶的盐浓度大于或等于形成纤维蛋白水凝胶的阈值浓度。 该方法进一步包括将纤维蛋白水凝胶与载体材料组合。 载体材料的浓度通常在0.1至约50重量％的范围内。 该方法还包括将盐浓度降低到阈值浓度以下以形成血纤蛋白水凝胶。
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公开(公告)号：WO2018067622A1
公开(公告)日：2018-04-12
申请号：PCT/US2017/055015
申请日：2017-10-04
Applicant: 3M INNOVATIVE PROPERTIES COMPANY
Inventor： DIZIO, James P. , TIAN, Zhicheng , BJORK, Jason W. , DETERMAN, Amy S. , ASMUS, Robert A. , O'HARE, Jonathan J.
Abstract: Provided is a method of forming a fibrinogen hydrogel composition, the method including providing a fibrinogen hydrogel or precursor thereof, comprising fibrinogen hydrogel forming salt. The fibrinogen hydrogel forming salt concentration is greater than or equal to the threshold concentration to form a fibrinogen hydrogel. The method further includes denaturing the fibrinogen hydrogel such as by heating. The method optionally further includes combining the fibrinogen hydrogel with a carrier material. When present, the concentration of the carrier material typically ranges from 0.1 to about 50 wt.-%. The method further includes reducing the salt concentration below the threshold concentration to form a fibrinogen hydrogel.
Abstract translation: 提供形成纤维蛋白原水凝胶组合物的方法，所述方法包括提供包含纤维蛋白原水凝胶形成盐的纤维蛋白原水凝胶或其前体。 形成纤维蛋白原水凝胶的盐浓度大于或等于阈值浓度以形成纤维蛋白原水凝胶。 该方法还包括例如通过加热使纤维蛋白原水凝胶变性。 该方法任选地进一步包括将纤维蛋白原水凝胶与载体材料组合。 当存在时，载体材料的浓度通常在0.1至约50重量％的范围内。 该方法还包括将盐浓度降低至低于阈值浓度以形成纤维蛋白原水凝胶。
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10.发明申请
公开(公告)号：WO2017058737A1
公开(公告)日：2017-04-06
申请号：PCT/US2016/053863
申请日：2016-09-27
Applicant: 3M INNOVATIVE PROPERTIES COMPANY
Inventor： BRUTINEL, Evan D. , BJORK, Jason W. , STANENAS, Adam J.
Abstract: In one aspect, the present disclosure provides a device. The device includes a body comprising a waterproof base, a waterproof coversheet attached to the base, and a channel disposed between the base and the coversheet. The channel has a perimeter and an opening that provides liquid access to the channel. A portion of the perimeter is defined by a waterproof seal. A dry first oxygen-scavenging reagent and an indicator reagent for detecting sulfate reduction by a sulfate-reducing bacterium are disposed in the device between the base and the coversheet. The waterproof base comprises a plurality of open microcompartment structures facing the coversheet.
Abstract translation: 一方面，本公开提供了一种装置。 该装置包括主体，该主体包括防水基座，附接到基座的防水覆盖片以及设置在基座和盖板之间的通道。 通道具有周边和开口，可以提供液体进入通道。 周边的一部分由防水密封限定。 干燥的第一氧气清除试剂和用于通过硫酸盐还原细菌检测硫酸盐还原的指示剂被设置在基底和覆盖片之间的装置中。 防水底座包括面向盖板的多个开放微型隔室结构。
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