公开(公告)号：WO2021059195A1

公开(公告)日：2021-04-01

申请号：PCT/IB2020/058951

申请日：2020-09-24

Applicant: 3M INNOVATIVE PROPERTIES COMPANY

Inventor： SGOLASTRA, Federica ,  ROSCOE, Stephen B. ,  DOHMEIER, Daniel M. ,  NAKAMURA, Masayuki ,  BOTHOF, Catherine A. ,  YUKSEL YURT, Deniz ,  JOHNSON, David D. ,  KALSTABAKKEN, Kyle A. ,  DAI, Minghua ,  KANG, Myungchan ,  PERCY, Neil ,  HORTON, Leslie M. ,  KENNEDY, Stephen M.

IPC: G01N33/543 ,  G01N33/552 ,  G01N33/532 ,  C03C12/00 ,  C03C11/002 ,  C03C17/30 ,  C03C2218/111 ,  G01N33/54313 ,  G01N33/54353

Abstract: A composition and method of detecting an analyte in a sample using the composition, the composition including: a liquid that includes water; a plurality of first hollow glass bubbles in the liquid; a plurality of covalently attached first affinity groups that are covalently attached to at least some of the plurality of first hollow glass bubbles; and a plurality of first detector compound molecules not covalently bonded to the plurality of first hollow glass bubbles; wherein the first detector compound molecules include a first detectable group that is detected at a first wavelength; and wherein the first hollow glass bubbles have: a density of less than 0.60 gram/mole; a span of less than 1.0; and a plurality of covalently attached first affinity groups.