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公开(公告)号：WO2021059195A1
公开(公告)日：2021-04-01
申请号：PCT/IB2020/058951
申请日：2020-09-24
Applicant: 3M INNOVATIVE PROPERTIES COMPANY
Inventor： SGOLASTRA, Federica , ROSCOE, Stephen B. , DOHMEIER, Daniel M. , NAKAMURA, Masayuki , BOTHOF, Catherine A. , YUKSEL YURT, Deniz , JOHNSON, David D. , KALSTABAKKEN, Kyle A. , DAI, Minghua , KANG, Myungchan , PERCY, Neil , HORTON, Leslie M. , KENNEDY, Stephen M.
IPC: G01N33/543 , G01N33/552 , G01N33/532 , C03C12/00 , C03C11/002 , C03C17/30 , C03C2218/111 , G01N33/54313 , G01N33/54353
Abstract: A composition and method of detecting an analyte in a sample using the composition, the composition including: a liquid that includes water; a plurality of first hollow glass bubbles in the liquid; a plurality of covalently attached first affinity groups that are covalently attached to at least some of the plurality of first hollow glass bubbles; and a plurality of first detector compound molecules not covalently bonded to the plurality of first hollow glass bubbles; wherein the first detector compound molecules include a first detectable group that is detected at a first wavelength; and wherein the first hollow glass bubbles have: a density of less than 0.60 gram/mole; a span of less than 1.0; and a plurality of covalently attached first affinity groups.
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2.发明申请
公开(公告)号：WO2019123124A1
公开(公告)日：2019-06-27
申请号：PCT/IB2018/059954
申请日：2018-12-12
Applicant: 3M INNOVATIVE PROPERTIES COMPANY
Inventor： LEWANDOWSKI, Kevin M. , ROSCOE, Stephen B. , GADDAM, Babu N. , WHITING, Bryan T. , BATTISTE, John L. , GRIESGRABER, George W.
IPC: C08F2/38 , C08F2/48 , C08F222/10 , C09J4/06 , C08F220/28
Abstract: Controlled radical initiators, reaction mixtures containing the controlled radical initiators and various ethylenically unsaturated monomers, polymeric materials formed from the reaction mixtures, crosslinkable compositions containing the polymeric materials, crosslinked compositions formed from the crosslinkable compositions, and articles containing the polymeric materials, the crosslinkable compositions, or the crosslinked compositions are provided. The controlled radical initiators are bis-dithiocarbamate or bis-dithiocarbonate compounds having a single carbon between the two dithiocarbamate or dithiocarbonate groups. Also attached to that single carbon is a ketone group.
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公开(公告)号：WO2011087711A1
公开(公告)日：2011-07-21
申请号：PCT/US2010/060936
申请日：2010-12-17
Applicant: 3M INNOVATIVE PROPERTIES COMPANY , ROSCOE, Stephen B. , BOLEA, Philip A. , MOELLER, Stephanie J.
Inventor： ROSCOE, Stephen B. , BOLEA, Philip A. , MOELLER, Stephanie J.
CPC classification number: G01N21/643 , C12Q1/04 , C12Q1/06
Abstract: A method of detecting microorganisms in a test sample is provided. The method includes the steps of: a) incubating the test sample with a growth media to form an incubated sample, wherein the growth media includes an enzyme substrate and the enzyme substrate includes an enzymatically hydrolysable group and a fluorescent group, wherein microorganisms present in the test sample include an enzyme that hydrolyzes the hydrolysable group from the fluorescent group to form a fluorescently detectable product, wherein the fluorescently detectable product has both an acidic and basic species; b) exciting the fluorescently detectable product with light having a wavelength of Exλiso for a time sufficient for the fluorescently detectable product to emit light, wherein Exλiso is the absorbance isosbestic point of the fluorescently detectable product; and c) detecting light emitted at a wavelength of Emλ1.
Abstract translation: 提供了一种检测试样中微生物的方法。 该方法包括以下步骤：a）用生长培养基孵育测试样品以形成孵育的样品，其中生长培养基包括酶底物，酶底物包括酶促水解基团和荧光基团，其中存在于 测试样品包括从荧光基团水解可水解基团以形成荧光可检测产物的酶，其中荧光检测产物具有酸性和碱性物质; b）用荧光检测产物发光的时间激发具有波长为Ex 2 iso的光的荧光检测产物，其中Ex 2 iso是荧光检测产物的吸光度等值点; 以及c）检测在Em≥1波长处发射的光。
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公开(公告)号：WO2021124116A1
公开(公告)日：2021-06-24
申请号：PCT/IB2020/061982
申请日：2020-12-15
Applicant: 3M INNOVATIVE PROPERTIES COMPANY
Inventor： YUKSEL YURT, Deniz , ROSCOE, Stephen B. , KANG, Myungchan , DAI, Minghua , SGOLASTRA, Federica
IPC: G01N33/53 , G01N33/569 , G01N33/58 , G01N33/5308 , G01N33/56961 , G01N33/587
Abstract: A method of detecting an analyte. The method includes providing a composition, the composition comprising nanoparticles coupled to a first aptamer and nanorods coupled to a second aptamer, wherein the composition is substantially free of aggregates of the nanoparticles and nanorods; contacting a sample with the composition; adding a reagent to change the morphologies of the nanoparticles or nanorods; detecting a first color change of nanoparticles responsive to a first analyte in the sample; and detecting a second color change of nanorods responsive to a second analyte in the sample.
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公开(公告)号：WO2019123176A1
公开(公告)日：2019-06-27
申请号：PCT/IB2018/060118
申请日：2018-12-14
Applicant: 3M INNOVATIVE PROPERTIES COMPANY
Inventor： RASMUSSEN, Jerald K. , ROSCOE, Stephen B. , GADDAM, Babu N. , GRIESGRABER, George W. , O'NEAL, Daniel J. , NARVESON, Eli
Abstract: First articles with covalently attached thiocarbonylthio-containing groups are provided. More specifically, the first articles are a functionalized substrate that contains a solid polymeric substrate with a plurality of thiocarbonylthio-containing groups covalently attached directly to carbon atoms in a polymeric backbone of the solid polymeric substrate. Methods of making the first articles with covalently attached thiocarbonylthio-containing groups are provided. Additionally, second articles and methods of using the first articles to generate second articles with covalently attached polymeric chains are provided.
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Patent Agency Ranking
公开(公告)号：WO2018178829A1
公开(公告)日：2018-10-04
申请号：PCT/IB2018/051990
申请日：2018-03-23
Applicant: 3M INNOVATIVE PROPERTIES COMPANY
Inventor： LEWANDOWSKI, Kevin M. , GADDAM, Babu N. , ROSCOE, Stephen B. , BATTISTE, John L.
IPC: C08F265/04 , C08F287/00 , C08F293/00 , C09J7/38
Abstract: Controlled radical initiators, reaction mixtures containing the controlled radical initiators and various ethylenically unsaturated monomers, polymeric materials formed from the reaction mixtures, crosslinkable compositions containing the polymeric materials, and crosslinked compositions formed from the crosslinkable compositions are provided. The controlled radical initiators are bis-dithiocarbamate or bis-dithiocarbonate compounds having a single carbon between the two dithiocarbamate or dithiocarbonate groups.
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公开(公告)号：WO2015191419A2
公开(公告)日：2015-12-17
申请号：PCT/US2015/034624
申请日：2015-06-08
Applicant: 3M INNOVATIVE PROPERTIES COMPANY
Inventor： ROSCOE, Stephen B. , KANG, Myungchan , BRUTINEL, Evan D. , MILLER, Jesse D. , CLINE, Renee K. , DAI, Minghua , LIU, Hsi-Chou
CPC classification number: B01L3/5029 , B01L3/502 , B01L2200/16 , B01L2300/0825 , B01L2400/0406 , B01L2400/0478 , G01N33/5304
Abstract: Assay devices are provided including a receptacle having a sample entry port; a plunger disposed within the receptacle; at least one reagent; a membrane attached to a first surface of the plunger; a wick providing capillary force; and a detection zone. The membrane includes a target conjugate zone in which affinity components are disposed. Capture compounds are immobilized in a detection zone, which is located between the target conjugate zone and the wick. A method of detecting a target analyte is also provided, including providing the assay device; providing a sample suspected to contain a target analyte; adding the sample onto the device; allowing the sample to travel along the membrane until the sample reaches the detection zone; immobilizing the target analyte through reaction of the target analyte with the capture compounds; reacting the immobilized target analyte with a reagent to generate a detectable signal; and detecting the generated signal.
Abstract translation: 提供测定装置，包括具有样品入口的容器; 设置在所述容器内的柱塞; 至少一种试剂; 膜附接到柱塞的第一表面; 提供毛细管力的灯芯; 和检测区。 膜包括其中配置亲和成分的靶共轭区。 捕获化合物被固定在位于靶共轭区和芯之间的检测区中。 还提供了检测目标分析物的方法，包括提供测定装置; 提供怀疑含有目标分析物的样品; 将样品添加到设备上; 允许样品沿着膜移动直到样品到达检测区域; 通过靶分析物与捕获化合物的反应固定目标分析物; 使固定化的目标分析物与试剂反应以产生可检测的信号; 并检测所生成的信号。
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公开(公告)号：WO2022263944A1
公开(公告)日：2022-12-22
申请号：PCT/IB2022/054699
申请日：2022-05-19
Applicant: 3M INNOVATIVE PROPERTIES COMPANY
Inventor： TIU, Brylee David B. , ROSCOE, Stephen B. , SCHMIDT, Daniel J. , FISHMAN, Joshua M.
IPC: C07C247/04 , C07C275/10 , C08F20/00
Abstract: An azido-containing monomer, a polymer containing monomeric units derived from the azido-containing monomer, and various articles containing a substrate and a coating layer of the polymer positioned on the substrate are provided. The azido groups, which are pendant groups of the polymer, can undergo a click chemistry reaction with an unsaturated compound such as those having a terminal -C≡CH group, a dibenzocyclooctyne-containing group, an unsaturated bicyclic olefinic group, or an amido group. The click chemistry reaction can be used to covalently attach a fluorescent or bioactive compound to the polymer.
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公开(公告)号：WO2021059058A1
公开(公告)日：2021-04-01
申请号：PCT/IB2020/058260
申请日：2020-09-04
Applicant: 3M INNOVATIVE PROPERTIES COMPANY
Inventor： ROSCOE, Stephen B. , BONILLA, Tonya D. , GRIESGRABER, George W.
IPC: C07H17/075 , A61L2/28 , C12M1/34 , C12Q1/22
Abstract: A self-contained biological sterilization indicator comprises: a housing; bacterial spores comprising, and/or capable of producing, an enzyme capable of catalyzing cleavage of an enzyme substrate; and a frangible container containing a composition, wherein the composition comprises the enzyme substrate, wherein if the frangible container is broken the composition will contact the bacterial spores to form a mixture having an initial pH in the range from 6.0 to 9.0. The enzyme substrate comprises a fluorinated 4'-alkylumbelliferyl α-D-glucopyranoside represented by the structural formula (I), wherein R is an alkyl group having from 1 to 12 carbon atoms. A biological sterilization indicator comprising a kit containing isolated components comprising (i) bacterial spores comprising, and/or capable of producing, an enzyme capable of catalyzing cleavage of the enzyme substrate and a method of assessing efficacy of a sterilization process are also disclosed.
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公开(公告)号：WO2020115661A1
公开(公告)日：2020-06-11
申请号：PCT/IB2019/060408
申请日：2019-12-03
Applicant: 3M INNOVATIVE PROPERTIES COMPANY
Inventor： BONILLA, Tonya D. , ROSCOE, Stephen B. , GRIESGRABER, George W.
IPC: C07H17/075 , A61L2/28
Abstract: A self-contained biological sterilization indicator comprises: a housing; bacterial spores comprising, and/or capable of producing, an enzyme capable of catalyzing cleavage of an enzyme substrate; and a frangible container containing a composition, wherein the composition comprises the enzyme substrate, wherein if the frangible container is broken the composition will contact the bacterial spores to form a mixture having an initial pH in the range from 6.0 to 9.0. The enzyme substrate comprises a fluorinated 4'-alkylumbelliferyl α-D-glucopyranoside represented by the structural formula (I) wherein one of R 1 and R 2 is F and the other is H, and R 3 is an alkyl group having from 1 to 12 carbon atoms. A biological sterilization indicator comprising a kit containing isolated components comprising (i) bacterial spores comprising, and/or capable of producing, an enzyme capable of catalyzing cleavage of the enzyme substrate and a method of assessing efficacy of a sterilization process are also disclosed.
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