Abstract:
The disclosed applicator includes an activation region having one or more pinch point levers in the cover of the applicator. Within the cover of the applicator is a deformable body and disposed within the deformable body is a frangible ampoule containing a solution. A user activates the pinch point levers to deform the deformable body and crush the frangible ampoule, releasing the solution. The hinging connection of the pinch point lever reduces the break strength needed in order to crush the ampoule, while the deformable body provides a safe barrier to protect the user against glass shards.
Abstract:
An applicator (100) including a hollow body (110), the hollow body including a distal portion (112), a proximal portion (114), an exterior surface (118), an interior surface (116), and an activation region (120), where the hollow body includes at least two longitudinal grooves (122) on at least one of the exterior surface and the interior surface in the activation region of the applicator, and where the hollow body has a first radial groove (124) in the activation region that is on at least one of the exterior surface or the interior surface. The applicator includes a frangible ampoule (160) inside the hollow body, the frangible ampoule configured to contain a solution. The applicator may include a head (140) having an absorbent component (150) capable of absorbing the contents of the frangible ampoule when the ampoule is fractured and can aid in application of the ampoule contents to the desired surface.
Abstract:
A wound dressing system comprising a drape and a hydrogel sealant. The drape comprises a film and an adhesive on a first major surface of the film. The hydrogel comprises at least 30% by weight water, a crosslinked hydrophilic absorbent polymer; and a swelling agent. The hydrogel can create a seal between the drape and a surface (e.g., a patient's skin), making the disclosed systems suitable for negative pressure wound therapy (NPWT) applications.
Abstract:
An applicator (100) comprising an elongated hollow body (120) comprising a distal portion (123), a proximal portion (124) having an open end, an exterior surface (127), an interior surface (126), and a filter (135). The interior surface of the applicator defines an internal chamber suitable for receiving an ampoule (160) formed of a frangible material located in the internal chamber proximal to the filter. A spacer (185) having a distal end and a proximal end is provided, and a cap (180) having a proximal portion, a distal portion, an exterior surface, and an interior surface is provided that attaches to the open end of the applicator and maintains the ampoule and spacer in their respective desired positions. The applicator comprises a head (140) including an absorbent component (110) that is capable of absorbing the contents of the frangible ampoule and facilitates applying the contents to the desired surface.
Abstract:
Provided is a method of forming a fibrinogen hydrogel composition, the method including providing a fibrinogen hydrogel or precursor thereof, comprising fibrinogen hydrogel forming salt. The fibrinogen hydrogel forming salt concentration is greater than or equal to the threshold concentration to form a fibrinogen hydrogel. The method further includes denaturing the fibrinogen hydrogel such as by heating. The method optionally further includes combining the fibrinogen hydrogel with a carrier material. When present, the concentration of the carrier material typically ranges from 0.1 to about 50 wt.-%. The method further includes reducing the salt concentration below the threshold concentration to form a fibrinogen hydrogel.
Abstract:
The invention includes a forced-air blanket for providing a profusion of air to a patient, comprising a bottom layer with a plurality of openings configured to allow a profusion of air to pass through the bottom layer and an upper layer bonded to the bottom layer around a periphery, wherein the upper layer is also bonded to bottom layer by a plurality of linear seals and a plurality of staked seals. In an embodiment, at least one of more of the linear seals have one end which is joined to a portion of the periphery. In another embodiment, the forced-air blanket may further include at least one elongated seal that is positioned proximate to the inlet. The arrangement of the plurality of staked seals, elongated seals and linear seals assists in providing a blanket that is of a low-profile with even air distribution.
Abstract:
Disclosed is a fibrinogen composition. The fibrinogen composition comprises denatured fibrinogen hydrogel having a fibrinogen concentration ranging from 0.1 to 15 wt.-% and a fibrinogen hydrogel forming salt at a concentration less than a threshold concentration to form the fibrinogen hydrogel. In some examples, the fibrinogen composition is dehydrated denatured fibrinogen hydrogel, where the fibrinogen composition comprises salt at a concentration no greater than 20 wt.-%.
Abstract:
Sterilization indicators that include a neutralizer, such indicators useful for testing the effectiveness of a sterilization procedure by measuring the activity of an active enzyme whose activity is correlated with the survival of microorganisms.