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公开(公告)号：WO2015038689A2
公开(公告)日：2015-03-19
申请号：PCT/US2014/055057
申请日：2014-09-11
Applicant: 3M INNOVATIVE PROPERTIES COMPANY
CPC classification number: A01N47/44 , A01N25/30 , A01N43/40 , A61K8/39 , A61K8/40 , A61K8/416 , A61K8/43 , A61K8/442 , A61K8/466 , A61K8/4926 , A61K8/4993 , A61K8/55 , A61K8/604 , A61K8/86 , A61K31/155 , A61L26/0066 , A61L2300/404 , A61Q11/00 , A61Q17/005 , A01N25/02
Abstract: An antiseptic composition comprising a multivalent cationic antiseptic present in an amount of 0.05 to 0.5 percent based upon the ready to use composition; an anionic compound which is water soluble in an amount of at least 0.1 grams in 100 grams water at 23°C, wherein the anionic compound is present at a concentration which would result in precipitation of the multivalent cationic antiseptic in the composition without a solubilizing surfactant present; and a solubilizing surfactant selected from the group consisting of zwitterionic surfactants, amine oxide surfactants, micelle-forming nonionic surfactants, and combinations thereof; wherein the solubilizing surfactant is present in sufficient amount to prevent the precipitation; and wherein the composition, with the antiseptic, surfactant and anionic compound combined with each other, is free of precipitate according to Test Method A; and without the surfactant, the composition contains a precipitate according to Test Method A; an oral care kit comprising the antiseptic composition and a delivery device; methods of decolonizing mucosal tissue, decontaminating wound tissue, and pretreating medical devices, comprising contacting the tissue or medical device with the antiseptic composition, and methods of preparing the compositions are provided.
Abstract translation: 一种防腐组合物，其包含多价阳离子防腐剂，其量为基于即用组合物的0.05至0.5％; 在23℃下在100克水中的水溶性至少为0.1克的阴离子化合物，其中阴离子化合物的存在浓度将导致组合物中多价阳离子防腐剂的沉淀，而没有增溶表面活性剂 当下; 和选自两性离子表面活性剂，氧化胺表面活性剂，胶束形成非离子表面活性剂及其组合的增溶表面活性剂; 其中增溶表面活性剂以足够的量存在以防止沉淀; 并且其中与防腐剂，表面活性剂和阴离子化合物相结合的组合物根据测试方法A不含沉淀物; 并且没有表面活性剂，根据测试方法A，组合物含有沉淀物; 包含所述防腐组合物和递送装置的口腔护理套件; 提供了使粘膜组织非殖化，去污伤口组织和预处理医疗装置的方法，包括使组织或医疗装置与防腐组合物接触，以及制备组合物的方法。
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公开(公告)号：EP3043786A2
公开(公告)日：2016-07-20
申请号：EP14843833.6
申请日：2014-09-11
Applicant: 3M Innovative Properties Company
IPC: A61K31/155 , A01N47/44
CPC classification number: A01N47/44 , A01N25/30 , A01N43/40 , A61K8/39 , A61K8/40 , A61K8/416 , A61K8/43 , A61K8/442 , A61K8/466 , A61K8/4926 , A61K8/4993 , A61K8/55 , A61K8/604 , A61K8/86 , A61K31/155 , A61L26/0066 , A61L2300/404 , A61Q11/00 , A61Q17/005 , A01N25/02
Abstract: An antiseptic composition comprising a multivalent cationic antiseptic present in an amount of 0.05 to 0.5 percent based upon the ready to use composition; an anionic compound which is water soluble in an amount of at least 0.1 grams in 100 grams water at 23°C, wherein the anionic compound is present at a concentration which would result in precipitation of the multivalent cationic antiseptic in the composition without a solubilizing surfactant present; and a solubilizing surfactant selected from the group consisting of zwitterionic surfactants, amine oxide surfactants, micelle-forming nonionic surfactants, and combinations thereof; wherein the solubilizing surfactant is present in sufficient amount to prevent the precipitation; and wherein the composition, with the antiseptic, surfactant and anionic compound combined with each other, is free of precipitate according to Test Method A; and without the surfactant, the composition contains a precipitate according to Test Method A; an oral care kit comprising the antiseptic composition and a delivery device; methods of decolonizing mucosal tissue, decontaminating wound tissue, and pretreating medical devices, comprising contacting the tissue or medical device with the antiseptic composition, and methods of preparing the compositions are provided.
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