公开(公告)号：JPH03190817A

公开(公告)日：1991-08-20

申请号：JP34119190

申请日：1990-11-30

Applicant: ABBOTT LAB

Inventor： DEIRU AARU BURINKAA ,  INRIIKU DEII IIBURIN

IPC: A61K31/19 ,  A61K9/20 ,  A61K9/22 ,  A61K9/50 ,  A61K9/52 ,  A61K9/54 ,  A61K9/58 ,  A61K9/62 ,  A61K31/505 ,  A61K47/32 ,  A61K47/36 ,  A61P9/12 ,  A61P25/08

Abstract: PURPOSE: To obtain a coated granule useful for preparing a preparation unit enabling the continuous sustained release of a medicine in a therapeutically effective level in a patient by coating a granule with an ethylcellulose or methacrylic acid methyl ester, a plasticizer and an agent for preventing sticking. CONSTITUTION: This sustained releasing preparation unit is sustained releasing coated granules coated with a composition containing 2-20% (W/V) ethylcellulose or methacrylic acid methyl ester, 0.1-5.0% plasticizer (e.g. a castor oil, propylene glycol), and 0.5-20% agent for preventing sticking (e.g. magnesium stearate, a talc). By mixing the granules with at least one viscous agent, preferably 2 viscous agents, the granules are formed as a preparation unit such as a tablet. As the viscous agent, a methylcellulose, a hydroxypolymethylcellulose, a povidone, and a hydroxypropylcellulose are used and blended in rations of 2-30wt.% primary viscous agent and 0-30wt.% secondary viscous agent in the preparation unit.