公开(公告)号：JP2007300967A

公开(公告)日：2007-11-22

申请号：JP2006129490

申请日：2006-05-08

Applicant: Abbott Lab ,  Toshiba Medical Systems Corp ,  アボット・ラボラトリーズAbbott Laboratories ,  東芝メディカルシステムズ株式会社

Inventor： KANAYAMA SHOICHI ,  KHALIL OMAR S

IPC: A61B5/1455 ,  A61B5/1491

CPC classification number: A61B5/6843

Abstract: PROBLEM TO BE SOLVED: To reduce influence of mechanical and thermal effects on the skin of the subject due to contact between a measurement probe and the skin.
SOLUTION: A non-invasive measurement apparatus for measuring glucose in a subject optically and non-invasively via the measurement probe 11 comprises a light source and a light detector 18 connected to the measurement probe, an applicator having a shape similar to that of the measurement probe, and a computer section 21 which controls the light source and the light detector. The computer section also controls the applicator to make the applicator contact the skin of the subject at a pressure higher than a pressure per unit area applied on the skin by the measurement probe during non-invasive measurement so as to stretch the skin of the subject before the non-invasive measurement.
COPYRIGHT: (C)2008,JPO&INPIT

Abstract translation: 要解决的问题：减少由于测量探针和皮肤之间的接触而引起的对受试者皮肤的机械和热效应的影响。 解决方案：用于通过测量探针11光学和非侵入地测量受试者中的葡萄糖的非侵入式测量装置包括光源和连接到测量探针的光检测器18，具有类似于其的形状的施加器 的测量探头，以及控制光源和光检测器的计算机部分21。 计算机部分还控制施用器，使得施用器在非侵入性测量期间以比在测量探针上施加在皮肤上的每单位面积的压力高的受压物体的皮肤接触，以便拉伸受试者的皮肤。 非侵入式测量。 版权所有（C）2008，JPO＆INPIT

公开(公告)号：JP2007083028A

公开(公告)日：2007-04-05

申请号：JP2006229227

申请日：2006-08-25

Applicant: Abbott Lab ,  Toshiba Medical Systems Corp ,  アボット・ラボラトリーズAbbott Laboratories ,  東芝メディカルシステムズ株式会社

Inventor： KANAYAMA SHOICHI ,  KONO YUKO ,  CHINEN MASARU ,  ONO MOTOHARU ,  KHALIL OMAR S

IPC: A61B5/1455 ,  G01N21/27

Abstract: PROBLEM TO BE SOLVED: To solve the problems that a part to be measured in a subject and a measurement condition are changed whenever measurement is performed or dependence is performed on the position of the part to be measured due to a difference in the tissue of the subject, etc., so as to differ a measurement result or that the component of light to be the main cause of inhibition in performing the quantitative analysis or qualitative analysis of tissue property in the subject is mixed when a desired optical signal is detected, which related to the tissue property of the subject. SOLUTION: In the noninvasive inspecting apparatus, the subject is irradiated with monochromatic light with at least one wavelengths or the desired light from an optical part 9, thereby detecting the light diffused, transmitted and/or reflected concerning the subject by the optical part 9 and noninvasively acquires information concerning the tissue property of the subject. The apparatus includes a mobile mechanism 5 arranged to move the optical part 9 so as to change the part to be irradiated and/or the part to be measured in the subject. COPYRIGHT: (C)2007,JPO&INPIT

Abstract translation: 要解决的问题：为了解决当测量被执行时要测量的被测部件和测量条件的变化的问题，或者由于在测量中的差异而对被测量部件的位置执行依赖性 对象的组织等，以便当所需的光信号为期望的光学信号为或不同时，测量结果不同，或者当对所述对象的组织特性进行定量分析或定性分析时，将所述光的成分作为抑制的主要原因混合 检测到，其与受试者的组织性质有关。 解决方案：在非侵入性检查装置中，用来自光学部件9的至少一个波长或期望光的单色光照射被摄体，从而通过光学器件检测对被摄体的光的漫射，透射和/或反射 第9部分并非侵入性地获取关于受试者的组织属性的信息。 该装置包括移动机构5，该移动机构5被布置成移动光学部件9，以便改变要被照射的部分和/或被检测部件。 版权所有（C）2007，JPO＆INPIT

公开(公告)号：JP2011206591A

公开(公告)日：2011-10-20

申请号：JP2011162533

申请日：2011-07-25

Applicant: Abbott Lab ,  Toshiba Medical Systems Corp ,  アボット・ラボラトリーズAbbott Laboratories ,  東芝メディカルシステムズ株式会社

Inventor： KANAYAMA SHOICHI ,  KHALIL OMAR S ,  JENG TZYY-WEN ,  YEH SHU-JEN

IPC: A61B5/1495 ,  A61B5/1455

Abstract: PROBLEM TO BE SOLVED: To provide a non-invasive estimation method of glucose and a non-invasive estimation device of glucose which enable the track of temperature-induced sugar decomposition in non-invasive estimation of glucose.SOLUTION: Owing to glucose metabolic change induction, glucose metabolism, and hemoglobin variant concentration change in a skin nutritional capillary, a localized reflectance optical probe which is adjusted at temperature different from skin temperature makes contact with skin. A time window for data collection which can minimize the impact of tissue-probe adaptability for a signal is selected. The change of a localized reflected light signal for various distances between a light source and a detector, various wavelengths, various degrees of contact time is measured from the skin contact of a probe for a given length of time. A function change in relation to the influence of heat stimulation for light absorption change by hemoglobin is calculated as a result of the influence of temperature for glucose metabolism. The function change in relation to the effect of heat stimulation for light attenuation change is calculated as a result of light scattering and blood flow change. The calibration relation between the combination of a function which is drawn from the signal of localized reflectance and glucose concentration is drawn. In order to predict a glucose concentration in a subject in subsequent time, measurement and the established calibration relation are used.

Abstract translation: 要解决的问题：提供葡萄糖的非侵入性估计方法和葡萄糖的非侵入性估计装置，其能够在葡萄糖的非侵入性估计中跟踪温度诱导的糖分解。解决方案：由于葡萄糖代谢变化诱导 ，葡萄糖代谢和血红蛋白变体浓度变化的皮肤营养毛细血管，在与皮肤温度不同的温度下调节的局部反射光学探针与皮肤接触。 选择可以最小化组织探针对信号的适应性的影响的用于数据收集的时间窗口。 根据探针的皮肤接触测量给定时间长度，测量光源和检测器之间各种距离的局部反射光信号的变化，各种波长，各种接触时间的程度。 作为葡萄糖代谢温度的影响的结果，计算出与热刺激对血红蛋白的光吸收变化的影响有关的功能变化。 作为光散射和血流变化的结果，计算与热刺激对光衰减变化的影响相关的功能变化。 绘制从局部反射信号和葡萄糖浓度之间的函数的组合之间的校准关系。 为了在随后的时间内预测受试者中的葡萄糖浓度，使用测量和建立的校准关系。

公开(公告)号：JP2008191160A

公开(公告)日：2008-08-21

申请号：JP2008032310

申请日：2008-02-13

Applicant: Abbott Lab ,  Toshiba Corp ,  アボット・ラボラトリーズAbbott Laboratories ,  株式会社東芝

Inventor： KANAYAMA SHOICHI ,  HENMI KAZUHIRO ,  KHALIL OMAR S ,  KANTOR STANISLAW

IPC: G01N29/00 ,  A61B8/00 ,  G01N29/02 ,  G10K15/00

Abstract: PROBLEM TO BE SOLVED: To precisely measure a very weak acoustic signal induced by energy absorption of irradiation light.
SOLUTION: This non-invasive biological information measuring instrument includes a light source 8, an irradiation part 10 for emitting light including a specified wavelength component generated in the light source, and an acoustic signal detecting part 11 having the transmissivity for the specified wavelength component, and arranged between a specimen and the irradiation part to detect the acoustic signal generated by the light energy absorption of a specified substance existing in the specimen, and the light emitted from the irradiation part irradiates the specimen via the acoustic signal detecting part.
COPYRIGHT: (C)2008,JPO&INPIT

Abstract translation: 要解决的问题：精确测量由照射光的能量吸收引起的非常弱的声信号。 解决方案：该无创生物信息测量仪器包括光源8，用于发射包括在光源中产生的特定波长分量的光的照射部分10和具有指定的透射率的声信号检测部分11 波长分量，并且配置在样本和照射部分之间，以检测由存在于样本中的特定物质的光能吸收产生的声信号，并且从照射部分发射的光通过声信号检测部照射样本。 版权所有（C）2008，JPO＆INPIT

公开(公告)号：JP2004147940A

公开(公告)日：2004-05-27

申请号：JP2002317801

申请日：2002-10-31

Applicant: Abbott Lab ,  Toshiba Corp ,  アボット・ラボラトリーズAbbott Laboratories ,  株式会社東芝

Inventor： KANAYAMA SHOICHI ,  HENMI KAZUHIRO ,  KHALIL OMAR S ,  KANTOR STANISLAW

IPC: G01N29/00 ,  A61B5/00 ,  A61B5/145 ,  A61B5/1455 ,  A61B8/00 ,  G01N21/00 ,  G01N21/17 ,  G01N29/22 ,  G01N29/24 ,  G01N29/32

CPC classification number: A61B5/1455 ,  A61B5/0095 ,  A61B5/14532 ,  A61B8/00 ,  G01N21/1702 ,  G01N29/22 ,  G01N29/2418 ,  G01N29/326 ,  G01N29/449 ,  G01N2291/015 ,  G01N2291/02466

Abstract: PROBLEM TO BE SOLVED: To provide a method and an instrument for noninvasive measurement of biological information capable of precisely measuring a very feeble acoustic signal induced by energy absorption of irradiating light.
SOLUTION: The instrument is provided with: a light source part 8; an irradiation part 10 for irradiating a patient with light including specific wavelength components generated by the light source part; a piezoelectric element 30 formed from a piezoelectric single crystal containing lead titanate; and an acoustic signal detection part 11 for detecting the acoustic signal generated by absorbing the energy of the irradiating light by a specific substance existing in the patient.
COPYRIGHT: (C)2004,JPO

公开(公告)号：JP2012045429A

公开(公告)日：2012-03-08

申请号：JP2011267232

申请日：2011-12-06

Applicant: Abbott Lab ,  Toshiba Medical Systems Corp ,  アボット・ラボラトリーズAbbott Laboratories ,  東芝メディカルシステムズ株式会社

Inventor： KANAYAMA SHOICHI ,  KHALIL OMAR S ,  YEH SHU-JEN

IPC: A61B5/1455

Abstract: PROBLEM TO BE SOLVED: To improve calibration accuracy to seasonal and psychological variation of tissue property.SOLUTION: A noninvasive measurement instrument has a measurement probe 1 supposed to get into touch with a trial subject, a light source 6 and a photodetector 7 to be connected to the measurement probe, and a computer section 5 for controlling the light source and photodetector to optically and noninvasively measure information relating to glucose in the trial subject and predict the value of glucose by a calibration model from an output of the photodetector. The computer section updates the calibration model by executing regression estimation based on the acquired data by noninvasive measurement on a different day and the corresponding reference measurement value and predicts glucose density from the acquired data by noninvasive measurement by using the updated calibration model.

Abstract translation: 要解决的问题：提高校准精度对组织属性的季节和心理变化。 解决方案：无创测量仪器具有测试探头1，该测量探针1应与试验对象接触，要连接到测量探针的光源6和光电检测器7以及用于控制光源的计算机部分5 光电检测器光学和非侵入性地测量与试验对象中的葡萄糖相关的信息，并且通过来自光电检测器的输出的校准模型预测葡萄糖的值。 计算机部分通过基于所获取的数据通过不同日期的无创测量和相应的参考测量值执行回归估计来更新校准模型，并且通过使用更新的校准模型通过非侵入式测量从所获取的数据中预测葡萄糖浓度。 版权所有（C）2012，JPO＆INPIT

公开(公告)号：JP2008045938A

公开(公告)日：2008-02-28

申请号：JP2006220289

申请日：2006-08-11

Applicant: Abbott Lab ,  Toshiba Corp ,  Toshiba Medical Systems Corp ,  アボット・ラボラトリーズAbbott Laboratories ,  東芝メディカルシステムズ株式会社 ,  株式会社東芝

Inventor： KANAYAMA SHOICHI ,  HENMI KAZUHIRO ,  KHALIL OMAR S ,  BRENDA CALFIN ,  NAIL LOOMIS ,  YEH SHU-JEN ,  RONALD HOHS

IPC: G01N21/00

Abstract: PROBLEM TO BE SOLVED: To compensate an influence of a bulk tissue characteristic to noninvasive measurement of an analysis object concentration in an object tissue, relative to an ultrasonic pulse generated in the object tissue in a specimen and propagated. SOLUTION: This analysis method has a step a for irradiating a specimen portion with a near infrared laser pulse from laser sources 15-18, and generating the ultrasonic pulse in the object tissue; a step b for detecting the ultrasonic pulse by a detector 32, and generating the first signal; a step c for generating the ultrasonic pulse in the object tissue by using a laser pulse having the same wavelength and energy as in the step b during an arrangement period of a light absorbing material between the laser sources and the specimen portion so that the ultrasonic pulse is generated in the light absorbing material, propagated through the tissue, and detected by the detector; a step d for detecting the ultrasonic pulse generated in the light absorbing material, and generating the second signal; a step e for calculating the intensity ratio between the first and second signals relative to each wavelength; a step f for calculating an absorption coefficient of the analysis object from the intensity ratio and an optical characteristic of the light absorbing material; and a step g for calculating the concentration of the analysis object from the calculated absorption coefficient, and calculating a molar absorption coefficient of the analysis object. COPYRIGHT: (C)2008,JPO&INPIT

Abstract translation: 要解决的问题：相对于在样本中的对象组织中产生的超声波脉冲，补偿体组织特征对对象组织中的分析对象浓度的无创测量的影响。 解决方案：该分析方法具有步骤a，用于用来自激光源15-18的近红外激光脉冲照射样本部分，并在对象组织中产生超声波脉冲; 用于通过检测器32检测超声波脉冲并产生第一信号的步骤b; 步骤c，用于在激光源和样本部分之间的光吸收材料的布置周期期间通过使用具有与步骤b相同的波长和能量的激光脉冲在对象组织中产生超声波脉冲，使得超声波脉冲 在光吸收材料中产生，传播通过组织，并由检测器检测; 步骤d，用于检测在吸光材料中产生的超声波脉冲，并产生第二信号; 用于计算相对于每个波长的第一和第二信号之间的强度比的步骤e; 用于根据光吸收材料的强度比和光学特性计算分析对象的吸收系数的步骤f; 以及从计算出的吸收系数计算分析对象的浓度并计算分析对象的摩尔吸光系数的步骤g。 版权所有（C）2008，JPO＆INPIT

公开(公告)号：JP2008005920A

公开(公告)日：2008-01-17

申请号：JP2006177127

申请日：2006-06-27

Applicant: Abbott Lab ,  Toshiba Medical Systems Corp ,  アボット・ラボラトリーズAbbott Laboratories ,  東芝メディカルシステムズ株式会社

Inventor： KANAYAMA SHOICHI ,  KHALIL OMAR S ,  YEH SHU-JEN

IPC: A61B5/1495 ,  A61B5/1455

Abstract: PROBLEM TO BE SOLVED: To improve the accuracy in calibration for the seasonal and physiological variation of tissue characteristics.
SOLUTION: The non-invasive measuring device comprises a measuring probe 1, a light source 6, a photodetector, and a computer part 5 which controls the light source and photodetector to measure the information on the glucose in a subject and which estimates the glucose value based on a calibration model output from the photodetector. The computer part 5 determines the calibrated regression parameter of the calibration model, determines the estimated regression parameter of the calibration model by executing the regression operation for a reference measurement value based on the calibration model from an estimated data set, checks the accuracy in the non-invasive measurement from the difference between the glucose concentration estimated using the calibration model based on the result of the non-invasive measurement and the reference glucose concentration, and updates the calibration model.
COPYRIGHT: (C)2008,JPO&INPIT

Abstract translation: 要解决的问题：提高组织特征的季节性和生理变化的校准精度。 解决方案：非侵入性测量装置包括测量探针1，光源6，光电检测器和计算机部分5，其控制光源和光电检测器以测量受试者中葡萄糖的信息，并且估计 基于从光电检测器输出的校准模型的葡萄糖值。 计算机部件5确定校准模型的校准回归参数，通过基于来自估计数据集的校准模型执行参考测量值的回归操作来确定校准模型的估计回归参数，检查非校准模型的准确性 使用基于非侵入性测量的结果的校准模型估计的葡萄糖浓度与参考葡萄糖浓度之间的差异进行侵入性测量，并更新校准模型。 版权所有（C）2008，JPO＆INPIT

公开(公告)号：JP2007151618A

公开(公告)日：2007-06-21

申请号：JP2005347194

申请日：2005-11-30

Applicant: Abbott Lab ,  Toshiba Medical Systems Corp ,  アボット・ラボラトリーズAbbott Laboratories ,  東芝メディカルシステムズ株式会社

Inventor： KANAYAMA SHOICHI ,  KHALIL OMAR S ,  JENG TZYY-WEN ,  YEH SHU-JEN

IPC: A61B5/1455

CPC classification number: A61B5/1455 ,  A61B5/14532

Abstract: PROBLEM TO BE SOLVED: To pursue temperature-induced glycolysis in the noninvasive measurement of glucose. SOLUTION: The change of glucose metabolism inside a skin nutrition capillary tube is induced, the change of localized reflectance optical signals in a plurality of distances between a light source and a detector and a plurality of wavelengths is measured as the function of the time of bringing a probe into contact with the skin, a time window capable of minimizing the influence of tissue and probe adaptation on signals is selected, and also the signals measured within the time window are used for the following calculation. One set of functions is calculated from a plurality of localized reflectance values in the plurality of distances between the light source and the detector and the plurality of wavelengths at a plurality of time intervals in at least two wavelengths within the time window, calibration relation between the combination of calculation functions and the glucose concentration of a living body is derived, and the calibration relation is used in order to predict the glucose concentration in body liquid in the following measurement. COPYRIGHT: (C)2007,JPO&INPIT

Abstract translation: 要解决的问题：在葡萄糖的无创测量中追求温度诱导的糖酵解。 解决方案：诱导皮肤营养毛细管内的葡萄糖代谢的变化，测量光源和检测器之间的多个距离和多个波长的局部反射光信号的变化，作为 选择使探针与皮肤接触的时间，能够使组织的影响最小化的时间窗口和探针适应对信号的选择，并且在时间窗口内测量的信号也用于以下计算。 从时间窗内的至少两个波长的多个时间间隔，在光源和检测器之间的多个距离中的多个局部反射率值和多个波长之间计算一组功能，校准关系 导出计算功能与生物体的葡萄糖浓度的组合，并采用校准关系，以便在以下测定中预测体液中的葡萄糖浓度。 版权所有（C）2007，JPO＆INPIT

公开(公告)号：WO9619731A3

公开(公告)日：1996-09-19

申请号：PCT/US9516464

申请日：1995-12-18

Applicant: ABBOTT LAB

Inventor： KHALIL OMAR S ,  HANLEY KATHLEEN A

IPC: G01N33/542 ,  C12Q1/68 ,  G01N33/543 ,  G01N33/534 ,  G01N33/569 ,  G01N33/571 ,  G01N33/58

CPC classification number: G01N33/54306 ,  C12Q1/6816 ,  C12Q1/6818

Abstract: The instant invention provides immunoassay methods whereby the presence or amount of multiple analytes that may be present in a test sample can be detected. According to one embodiment, the method comprises the steps of: (a) contacting a test sample with a common capture reagent for a time and under conditions sufficient to form capture reagent/analyte complexes wherein the common capture reagent includes one or more specific binding members that immobilize at least two analytes that may be present in said test sample; (b) contacting the capture reagent/analyte complexes with at least two indicator reagents for a time and under conditions sufficient to form capture reagent/analyte/indicator reagent complexes; and (c) detecting at least two measurable signals as a measure of the presence or amount of the analytes in the test sample. Indicator reagents which are employed in the above embodiment can comprise detectable moieties from at least two distinct detectable moiety classes. The invention also applies to detecting multiple nucleic acid sequences which may be present in a test sample.