公开(公告)号：WO2011156337A3

公开(公告)日：2012-04-26

申请号：PCT/US2011039397

申请日：2011-06-07

Applicant: ABBOTT LAB ,  ENANTA PHARM INC ,  CHEN HUI-JU ,  MCDANIEL KEITH F ,  GREEN BRIAN E ,  SHANLEY JASON P ,  KRUGER ALBERT W ,  GANDARILLA JORGE ,  WELCH DENNIE S ,  CINK RUSSELL D ,  GAI YONGHUA ,  WANG GUOQIANG ,  OR YAT SUN

Inventor： CHEN HUI-JU ,  MCDANIEL KEITH F ,  GREEN BRIAN E ,  SHANLEY JASON P ,  KRUGER ALBERT W ,  GANDARILLA JORGE ,  WELCH DENNIE S ,  CINK RUSSELL D ,  GAI YONGHUA ,  WANG GUOQIANG ,  OR YAT SUN

IPC: C07D487/04 ,  A61K31/407 ,  A61K31/498 ,  A61P31/14

CPC classification number: C07K5/081 ,  C07D487/04

Abstract: The present invention relates to novel macrocyclic compounds and methods of treating a hepatitis C infection in a subject in need of such therapy with said macrocyclic compounds. The present invention further relates to pharmaceutical compositions comprising the compounds of the present invention, or pharmaceutically acceptable salts, esters, or prodrugs thereof, in combination with a pharmaceutically acceptable carrier or excipient.

Abstract translation: 本发明涉及新的大环化合物和在需要用所述大环化合物进行这种治疗的受试者中治疗丙型肝炎感染的方法。 本发明还涉及包含本发明化合物或其药学上可接受的盐，酯或前药与药学上可接受的载体或赋形剂组合的药物组合物。

公开(公告)号：ES2423668T3

公开(公告)日：2013-09-23

申请号：ES10720502

申请日：2010-05-20

Applicant: ABBOTT LAB ,  ABBOTT GMBH & CO KG ,  ABBVIE INC

Inventor： WELCH DENNIE S ,  AKRITOPOULOU-ZANZE IRINI ,  BRAJE WILFRIED ,  DJURIC STEVAN W ,  WILSON NOEL S ,  TURNER SEAN C ,  KRUGER ALBERT W ,  RELO ANA-LUCIA ,  SHEKHAR SHASHANK ,  ZHAO HONGYU ,  GANDARILLA JORGE ,  GASIECKI ALAN F ,  LI HUANQIU ,  THOMPSON CHRISTINA M ,  ZHANG MIN

IPC: C07D487/04 ,  A61K31/551 ,  A61K31/553 ,  A61K31/554 ,  A61P25/00 ,  C07D491/04 ,  C07D495/04

Abstract: Un compuesto de fórmula (I):**Fórmula** o una sal farmacéuticamente aceptable del mismo,donde A está seleccionado entre el grupo que consiste en R1, R3, R4, y R5 están seleccionados independientemente entre el grupo que consiste en hidrógeno, alquenilo, alquilo, haloalquilo, G1, G2, -(CR4aR5a)m-G1, y -(CR4aR5a)m-G2; R4a y R5a, en cada caso, cada uno es independientemente hidrógeno, halógeno, alquilo, o haloalquilo; G1, en cada caso, es independientemente arilo o heteroarilo, donde cada G1 está independientemente sin sustituir osustituido con 1, 2, 3, 4 o 5 sustituyentes seleccionados entre el grupo que consiste en alquilo, alquenilo, alquinilo,halógeno, ciano, -NO2, -OR1b, -OC(O)R1b, -OC(O)N(Rb)(R3b), -SR1b, -S(O)R2b, -S(O)2R2b, -S(O)2N(Rb)(R3b), -C(O)R1b,-C(O)OR1b, -C(O)N(Rb)(R3b), -N(Rb)(R3b), -N(Ra)C(O)R1b, -N(Ra)C(O)O(R1b), -N(Ra)C(O)N(Rb)(R3b), -(CR4bR5b)m-NO2,-N(Rb)S(O)2(R2b), -(CR4bR5b)m-OR1b, -C(OH)[(CR4bR5b)m-R4b]2, -(CR4bR5b)m-OC(O)R1b, -(CR4bR5b)m-OC(O)N(Rb)(R3b), -(CR4bR5b)m-SR1b, -(CR4bR5b)m-S(O)R2b, -(CR4bR5b)m-S(O)2R2b, -(CR4bR5b)m-S(O)2N(Rb)(R3b),-(CR4bR5b)m-C(O)R1b, -(CR4bR5b)m-C(O)OR1b, -(CR4bR5b)m-C(O)N(Rb)(R3b), -(CR4bR5b)m-N(Rb)(R3b), -(CR4bR5b)m-N(Ra)C(O)R1b, -(CR4bR5b)m-N(Ra)C(O)O(R1b), -(CR4bR5b)m-N(Ra)C(O)N(Rb)(R3b), -(CR4bR5b)m-N(Rb)S(O)2(R2b),cianoalquilo, y haloalquilo.

公开(公告)号：NZ596827A

公开(公告)日：2014-01-31

申请号：NZ59682710

申请日：2010-05-20

Applicant: ABBOTT LAB ,  ABBOTT GMBH & CO KG

Inventor： WELCH DENNIE S ,  SHEKHAR SHASHANK ,  AKRITOPOULOU-ZANZE IRINI ,  BRAJE WILFRIED ,  RELO ANA-LUCIA ,  TURNER SEAN C ,  GANDARILLA JORGE ,  WILSON NOEL S ,  GASIECKI ALAN F ,  ZHANG MIN ,  DJURIC STEVAN W ,  ZHAO HONGYU ,  KRUGER ALBERT W ,  THOMPSON CHRISTINA M ,  LI HUANQIU

IPC: C07D487/04 ,  A61K31/551 ,  A61K31/553 ,  A61K31/554 ,  A61P25/00 ,  C07D225/00 ,  C07D491/04 ,  C07D495/04

Abstract: 596827 Disclosed is a compound of formula (I), such as (3aS,10bS)-8-chloro-2-methyl-1,2,3,3a,4,5-hexahydrobenzo[e]pyrrolo [3,4-c]azepin-6(10bH)-one and (3aS,10bS)-8-chloro-2-methyl-1,2,3,3a,4,5-hexahydrobenzo[e]pyrrolo [3,4-c]azepin-6(10bH)-one, which is useful for treating disorders associated with 5HT receptors. Also disclosed is a process for making such compounds.

公开(公告)号：HK1168853A1

公开(公告)日：2013-01-11

申请号：HK12109595

申请日：2012-09-28

Applicant: ABBOTT LAB ,  ABBOTT GMBH & CO KG

Inventor： WELCH DENNIE S ,  AKRITOPOULOU-ZANZE IRINI ,  BRAJE WILFRIED ,  DJURIC STEVAN W ,  WILSON NOEL S ,  TURNER SEAN C ,  KRUGER ALBERT W ,  RELO ANA-LUCIA ,  SHEKHAR SHASHANK ,  ZHAO HONGYU ,  GANDARILLA JORGE ,  GASIECKI ALAN F ,  LI HUANQIU ,  THOMPSON CHRISTINA M ,  ZHANG MIN

IPC: C07D20060101 ,  A61K20060101 ,  A61P20060101

公开(公告)号：MX2011012479A

公开(公告)日：2012-03-06

申请号：MX2011012479

申请日：2010-05-20

Applicant: ABBOTT LAB

Inventor： TURNER SEAN C ,  GASIECKI ALAN F ,  AKRITOPOULOU-ZANZE IRINI ,  BRAJE WILFRIED ,  ZHANG MIN ,  DJURIC STEVAN W ,  GANDARILLA JORGE ,  SHEKHAR SHASHANK ,  WILSON NOEL S ,  RELO ANA-LUCIA ,  WELCH DENNIE S ,  KRUGER ALBERT W ,  ZHAO HONGYU ,  LI HUANQIU ,  THOMPSON CHRISTINA M

IPC: C07D487/04 ,  A61K31/551 ,  A61K31/553 ,  A61K31/554 ,  A61P25/00 ,  C07D491/04 ,  C07D495/04

Abstract: La presente solicitud se refiere a derivados de decahidropirroloazepina fusionada a arilo- y heteroarilo, octahidrooxepinopirrol, dióxido de octahidropirrolotiazepina, decahidrociclohepta[c]pirrol, y octahidrociclohepta[cjpirrol de fórmula (I) (ver fórmula (I)) en donde R1, R2, R3, R4, R5, A, Y1, Y2, e Y3 son como se define en la especificación. La presente solicitud también se refiere a composiciones que comprenden tales compuestos, procesos para hacer tales compuestos, y métodos para tratar condiciones de enfermedad utilizando tales compuestos y composiciones y métodos para identificar tales compuestos.

公开(公告)号：CA2761961A1

公开(公告)日：2010-11-25

申请号：CA2761961

申请日：2010-05-20

Applicant: ABBOTT LAB ,  ABBOTT GMBH & CO KG

Inventor： AKRITOPOULOU-ZANZE IRINI ,  BRAJE WILFRIED ,  DJURIC STEVAN W ,  WILSON NOEL S ,  TURNER SEAN C ,  KRUGER ALBERT W ,  RELO ANA-LUCIA ,  SHEKHAR SHASHANK ,  WELCH DENNIE S ,  ZHAO HONGYU ,  GANDARILLA JORGE ,  GASIECKI ALAN F ,  LI HUANQIU ,  THOMPSON CHRISTINA M ,  ZHANG MIN

IPC: C07D487/04 ,  A61K31/551 ,  A61K31/553 ,  A61K31/554 ,  A61P25/00 ,  C07D491/04 ,  C07D495/04

Abstract: The present application relates to aryl- and heteroaryl-fused decahydropyrroloazepine, octahydrooxepinopyrrole, octahydropyrrolothiazepine dioxide, decahydrocyclohepta[c]pyrrole, and octahydrocyclohepta[c]pyrrole derivatives of formula (I), wherein R1,R2, R3, R4, R5, A, Y1, Y2, and Y3 are as defined in the specification. The present application also relates to compositions comprising such compounds, processes for making such compounds, and methods of treating disease conditions using such compounds and compositions, and methods for identifying such compounds.

公开(公告)号：AU2010353724A1

公开(公告)日：2012-12-20

申请号：AU2010353724

申请日：2010-11-19

Applicant: ABBOTT LAB ,  ABBOTT GMBH & CO KG

Inventor： AKRITOPOULOU-ZANZE IRINI ,  BRAJE WILFRIED ,  DJURIC STEVAN W ,  WILSON NOEL S ,  TURNER SEAN C ,  KRUGER ALBERT W ,  RELO ANA-LUCIA ,  SHEKHAR SHASHANK ,  WELCH DENNIE S ,  ZHAO HONGYU ,  GANDARILLA JORGE ,  GASIECKI ALAN F ,  LI HUANQIU ,  THOMPSON CHRISTINA M ,  ZHANG MIN

IPC: A01N43/00 ,  A01N43/46 ,  A61K31/55

Abstract: The present application relates to aryl- and heteroaryl-fused decahydropyrroloazepine, octahydrooxepinopyrrole, octahydropyrrolothiazepine dioxide, decahydrocyclohepta[

公开(公告)号：CA2761961C

公开(公告)日：2017-10-24

申请号：CA2761961

申请日：2010-05-20

Applicant: ABBOTT LAB ,  ABBOTT GMBH & CO KG

Inventor： AKRITOPOULOU-ZANZE IRINI ,  BRAJE WILFRIED ,  DJURIC STEVAN W ,  WILSON NOEL S ,  TURNER SEAN C ,  KRUGER ALBERT W ,  RELO ANA-LUCIA ,  SHEKHAR SHASHANK ,  WELCH DENNIE S ,  ZHAO HONGYU ,  GANDARILLA JORGE ,  GASIECKI ALAN F ,  LI HUANQIU ,  THOMPSON CHRISTINA M ,  ZHANG MIN

IPC: C07D487/04 ,  A61K31/551 ,  A61K31/553 ,  A61K31/554 ,  A61P25/00 ,  C07D491/04 ,  C07D495/04

Abstract: The present application relates to aryl- and heteroaryl-fused decahydropyrroloazepine, octahydroox-epinopyrrole, octahydropyrrolothiazepine dioxide, decahy-drocyclohepta[c]pyrrole, and octahydrocyclohepta[c]pyr-role derivatives of formula (I), wherein R1, R2, R3, R4, R5, A, Y1, Y2, and Y3 are as defined in the specification. The present application also relates to compositions comprising such compounds, processes for making such compounds, and methods of treating disease conditions using such compounds and compositions, and methods for identifying such compounds.

公开(公告)号：SG185672A1

公开(公告)日：2013-01-30

申请号：SG2012085346

申请日：2010-11-19

Applicant: ABBOTT LAB ,  ABBOTT GMBH & CO KG

Inventor： AKRITOPOULOU-ZANZE IRINI ,  BRAJE WILFRIED ,  DJURIC STEVAN W ,  WILSON NOEL S ,  TURNER SEAN C ,  KRUGER ALBERT W ,  RELO ANA-LUCIA ,  SHEKHAR SHASHANK ,  WELCH DENNIE S ,  ZHAO HONGYU ,  GANDARILLA JORGE ,  GASIECKI ALAN F ,  LI HUANQIU ,  THOMPSON CHRISTINA M ,  ZHANG MIN

Abstract: The present application relates to aryl- and heteroaryl-fused decahydropyrroloazepine, octahydrooxepinopyrrole, octahydropyrrolothiazepine dioxide, decahydrocyclohepta[c]pyrrole, and octahydrocyclohepta[c]pyrrole derivatives of formula (I) wherein R1, R2, R3, R4, R5, A, Y1, Y2, and Y3 are as defined in the specification. The present application also relates to compositions comprising such compounds, processes for making such compounds, and methods of treating disease conditions using such compounds and compositions, and methods for identifying such compounds.

公开(公告)号：SG176100A1

公开(公告)日：2011-12-29

申请号：SG2011084357

申请日：2010-05-20

Applicant: ABBOTT LAB

Inventor： AKRITOPOULOU-ZANZE IRINI ,  BRAJE WILFRIED ,  DJURIC STEVAN W ,  WILSON NOEL S ,  TURNER SEAN C ,  KRUGER ALBERT W ,  RELO ANA-LUCIA ,  SHEKHAR SHASHANK ,  WELCH DENNIE S ,  ZHAO HONGYU ,  GANDARILLA JORGE ,  GASIECKI ALAN F ,  LI HUANQIU ,  THOMPSON CHRISTINA M ,  ZHANG MIN

Abstract: The present application relates to aryl- and heteroaryl-fused decahydropyrroloazepine, octahydrooxepinopyrrole, octahydropyrrolothiazepine dioxide, decahydrocyclohepta[c]pyrrole, and octahydrocyclohepta[c]pyrrole derivatives of formula (I), wherein R1,R2, R3, R4, R5, A, Y1, Y2, and Y3 are as defined in the specification. The present application also relates to compositions comprising such compounds, processes for making such compounds, and methods of treating disease conditions using such compounds and compositions, and methods for identifying such compounds.