公开(公告)号：ZA9704683B

公开(公告)日：1997-12-30

申请号：ZA9704683

申请日：1997-05-28

Applicant: ABBOTT LAB

Inventor： BROOKS CLINT D W ,  KOLASA TEODOZYJ ,  LEE WENDY ,  STEWART ANDREW O

IPC: C07C251/16 ,  C07C251/60 ,  C07C259/06 ,  C07D257/04 ,  C07D ,  A61K

CPC classification number: C07D257/04 ,  C07C251/16 ,  C07C251/60 ,  C07C259/06 ,  Y10S514/824 ,  Y10S514/825 ,  Y10S514/863 ,  Y10S514/886 ,  Y10S514/887 ,  Y10S514/916

公开(公告)号：ZA948309B

公开(公告)日：1995-08-04

申请号：ZA948309

申请日：1994-10-21

Applicant: ABBOTT LAB

Inventor： DELLARIA JOSEPH F ,  BASHA ANWER ,  BLACK LAWRENCE A ,  CHERNESKY LINDA J ,  LEE WENDY

IPC: C07C275/32 ,  C07C317/42 ,  C07C323/41 ,  C07C323/44 ,  C07C335/20 ,  C07D295/215 ,  A01N ,  A61K

Abstract: Compounds of structure where W is selected from the group consisting of where Q is oxygen or sulfur, R7 and R8 are independently selected from hydrogen and alkyl, or R7 and R8, together with the nitrogen atoms to which they are attached, define a radical of formula L1 and L2 are independently selected from a valence bond, alkylene, propenylene, and propynylene; R1, R2, R3, and R4 are independently selected from alkyl, alkoxy, haloalkyl, halogen, cyano, amino, alkoxycarbonyl, and dialkylaminocarbonyl; Y is oxygen, >NR11, where R11 is hydrogen or alkyl, or where n=0, 1, or 2; and R5 and R6 are alkyl, inhibit the biosynthesis of leukotrienes. These compounds are useful in the treatment or amelioration of allergic and inflammatory disease states.

公开(公告)号：ZA9408309B

公开(公告)日：1995-08-04

申请号：ZA9408309

申请日：1994-10-21

Applicant: ABBOTT LAB

Inventor： DELLARIA JOSEPH F ,  BASHA ANWER ,  BLACK LAWRENCE A ,  CHERNESKY LINDA J ,  LEE WENDY

IPC: C07C275/32 ,  C07C317/42 ,  C07C323/41 ,  C07C323/44 ,  C07C335/20 ,  C07D295/215 ,  A01N ,  A61K

CPC classification number: C07D295/215 ,  C07C275/32 ,  C07C317/42 ,  C07C323/41 ,  C07C323/44 ,  C07C335/20 ,  C07C2601/14

公开(公告)号：ZA9408250B

公开(公告)日：1995-08-02

申请号：ZA9408250

申请日：1994-10-20

Applicant: ABBOTT LAB

Inventor： DELLARIA JOSEPH F ,  BLACK LAWRENCE A ,  LEE WENDY ,  BASHA ANWER ,  CHERNESKY LINDA J

IPC: C07D309/10 ,  C07D405/12 ,  A01N ,  A61K

CPC classification number: C07D405/12 ,  C07D309/10

公开(公告)号：ZA9704688B

公开(公告)日：1997-12-30

申请号：ZA9704688

申请日：1997-05-28

Applicant: ABBOTT LAB

Inventor： BROOKS CLINT D W ,  KOLASA TEODOZYJ ,  LEE WENDY ,  STEWART ANDREW O

IPC: C07C317/32 ,  C07D209/14 ,  C07D257/04 ,  C07D401/06 ,  C07D401/12 ,  C07D403/12 ,  C07D405/12 ,  C07D417/12 ,  C07D417/14 ,  C07D ,  A61K

CPC classification number: C07D257/04 ,  C07C317/32 ,  C07C2602/08 ,  C07D209/14 ,  C07D401/06 ,  C07D401/12 ,  C07D403/12 ,  C07D405/12 ,  C07D417/12 ,  C07D417/14

公开(公告)号：ZA974688B

公开(公告)日：1997-12-30

申请号：ZA974688

申请日：1997-05-28

Applicant: ABBOTT LAB

Inventor： BROOKS CLINT D W ,  KOLASA TEODOZYJ ,  LEE WENDY ,  STEWART ANDREW O

IPC: C07C317/32 ,  C07D209/14 ,  C07D257/04 ,  C07D401/06 ,  C07D401/12 ,  C07D403/12 ,  C07D405/12 ,  C07D417/12 ,  C07D417/14 ,  C07D ,  A61K

Abstract: Described herein are compounds having the formula thereof wherein L is selected from the group consisting of R2 is selected from (a) (b) (c) (d) R3 is selected from optionally substituted phenyl, and optionally substituted pyridyl; Y is selected from halogen, alkyl, haloalkyl, alkoxy, pyridylmethoxy, thiazolylmethoxy, benzothiazolylmethoxy, quinolylmethoxy, and optionally substituted quinolylmethoxy; W is selected from hydrogen, alkyl, hydroxyalkyl, and hydroxy; A is absent or is selected from optionally substituted alkylene optionally substituted cycloalkylene, optionally substituted cycloalkylene wherein one or two of the carbon atoms is replaced with one or two heteroatoms independently selected from O, S, and N, and and X is absent or is alkylene; Z is selected from (a) hydrogen, (b) COM wherein M is selected from (b-1) a pharmaceutically acceptable metabolically cleavable group, (b-2)-OR10,(b-3)-O(CH2)w-CH(OR12)-CH2OR13, and (b-4)-NR15R16(c)-OR17, (d) tetrazolyl, (e)-CH(OR17)-CH2OR18,(f)-CH(OR17)-CH2-CH2OR18, (g)-CH(OR17)-CH(OR18)-CH2OR19, and (h)=N-OR17; and R1 and R4 selected from (a) hydrogen, (b) alkyl, and (c) optionally substituted phenyl, are prostaglandin biosynthesis inhibitors and are useful in the treatment of inflammatory disease states. Also disclosed are prostaglandin inhibiting compositions, and a method of inhibiting prostaglandin biosynthesis in a mammal.

公开(公告)号：ZA974683B

公开(公告)日：1997-12-30

申请号：ZA974683

申请日：1997-05-28

Applicant: ABBOTT LAB

Inventor： BROOKS CLINT D W ,  KOLASA TEODOZYJ ,  LEE WENDY ,  STEWART ANDREW O

IPC: C07C251/16 ,  C07C251/60 ,  C07C259/06 ,  C07D257/04 ,  C07D ,  A61K

公开(公告)号：ZA948250B

公开(公告)日：1995-08-02

申请号：ZA948250

申请日：1994-10-20

Applicant: ABBOTT LAB

Inventor： LEE WENDY ,  DELLARIA JOSEPH F ,  BLACK LAWRENCE A ,  BASHA ANWER ,  CHERNESKY LINDA J

IPC: C07D309/10 ,  C07D405/12 ,  A01N ,  A61K

Abstract: Compounds of the structure where W is selected from where Q is oxygen or sulfur, R6 and R7 are hydrogen or alkyl, or R6 and R7, together with the nitrogen atoms to which they are attached, define a radical of formula Z is -CH2-, oxygen, sulfur, or -NR9, L1 and L2 are selected from a valence bond, alkylene, propenylene, and propynylene; R1 and R2 are independently selected from alkyl, alkoxy, haloalkyl, halogen, cyano, amino, alkoxycarbonyl, and dialkylaminocarbonyl; Y is selected from oxygen, >NR10, and three carbon atoms, propenylene, propynylene, and R3, R4, and R5 are hydrogen or alkyl of one to four carbon atoms inhibit the synthesis of leukotrienes. These compounds are useful in the treatment or amelioration of allergic and inflammatory disease states.