公开(公告)号：ZA9406331B

公开(公告)日：1995-05-08

申请号：ZA9406331

申请日：1994-08-19

Applicant: ABBOTT LAB

Inventor： DELLARIA JOSEPH F ,  BASHA ANWER ,  BLACK LAWRENCE A ,  CHERNESKY LINDA J ,  LEE WENDY E

IPC: C07D309/04 ,  C07D309/06 ,  C07D405/12 ,  A61K ,  C07D

CPC classification number: C07D405/12 ,  C07D309/04 ,  C07D309/06

公开(公告)号：ZA946331B

公开(公告)日：1995-05-08

申请号：ZA946331

申请日：1994-08-19

Applicant: ABBOTT LAB

Inventor： DELLARIA JOSEPH F ,  BASHA ANWER ,  BLACK LAWRENCE A ,  CHERNESKY LINDA J ,  LEE WENDY E

IPC: C07D309/04 ,  C07D309/06 ,  C07D405/12 ,  A61K ,  C07D

Abstract: Compounds of structure where W is selected from where Q is oxygen or sulfur, R5 and R6 are independently selected from hydrogen and alkyl, or R5 and R6, together with the nitrogen atoms to which they are attached, define a radical of formula L1 and L2 are independently selected from a valence bond, alkylene, propenylene, and propynylene, R1, R2, R3, and R4 are independently selected from alkyl, alkoxy, haloalkyl, halogen, cyano, amino, alkoxycarbonyl, and dialkylaminocarbonyl, Y is oxygen, >NR9 where R9 is hydrogen or alkyl, or where n=0, 1, or 2, and A is selected from inhibit the biosynthesis of leukotrienes. These compounds are useful in the treatment or amelioration of allergic and inflammatory disease states.