公开(公告)号：WO2011014659A3

公开(公告)日：2011-04-21

申请号：PCT/US2010043716

申请日：2010-07-29

Applicant: ABBOTT LAB ,  GHAYUR TARIQ ,  LIU JUNJIAN ,  IBRAGHIMOV ALEXANDER

Inventor： GHAYUR TARIQ ,  LIU JUNJIAN ,  IBRAGHIMOV ALEXANDER

IPC: C12P21/08

CPC classification number: C07K16/468 ,  C07K16/2803 ,  C07K16/2851 ,  C07K16/2863 ,  C07K16/2887 ,  C07K16/32 ,  C07K2317/24 ,  C07K2317/31 ,  C07K2317/53 ,  C07K2317/56 ,  C07K2317/71 ,  C07K2317/73 ,  C07K2317/732 ,  C07K2317/92 ,  G01N33/6854

Abstract: The present invention relates to engineered multivalent and multispecific binding proteins, methods of making, and specifically to their uses in the prevention, diagnosis, and/or treatment of disease.

公开(公告)号：WO2012061558A3

公开(公告)日：2013-01-17

申请号：PCT/US2011059074

申请日：2011-11-03

Applicant: ABBOTT LAB ,  GHAYUR TARIQ ,  LIU JUNJIAN ,  ISAKSON PETER C

Inventor： GHAYUR TARIQ ,  LIU JUNJIAN ,  ISAKSON PETER C

IPC: C12P21/08 ,  A61K39/395 ,  C07K16/00

CPC classification number: C07K16/468 ,  C07K16/22 ,  C07K16/247 ,  C07K16/248 ,  C07K16/2803 ,  C07K16/2809 ,  C07K16/2827 ,  C07K16/2851 ,  C07K16/2863 ,  C07K16/2878 ,  C07K16/2887 ,  C07K16/32 ,  C07K16/34 ,  C07K16/44 ,  C07K2317/31

Abstract: Engineered multivalent and multispecific binding proteins, methods of making, and their uses in the prevention, diagnosis, and/or treatment of disease are provided.

Abstract translation: 提供了工程化的多价和多特异性结合蛋白，制备方法及其在预防，诊断和/或治疗疾病中的用途。

公开(公告)号：WO2012006490A4

公开(公告)日：2012-05-24

申请号：PCT/US2011043297

申请日：2011-07-08

Applicant: ABBOTT LAB ,  GHAYUR TARIQ ,  LIU JUNJIAN

Inventor： GHAYUR TARIQ ,  LIU JUNJIAN

IPC: A61K39/00 ,  C12N5/07 ,  C12N5/16 ,  C12P21/08

CPC classification number: C07K16/468 ,  A61K39/3955 ,  A61K45/06 ,  A61K47/6845 ,  C07K16/22 ,  C07K16/2863 ,  C07K16/2887 ,  C07K16/2896 ,  C07K2317/24 ,  C07K2317/31 ,  C07K2317/64 ,  C07K2317/73 ,  C07K2317/76 ,  C07K2317/92 ,  G01N33/6872

Abstract: Methods of making engineered multivalent and multi-specific binding proteins, and using the binding proteins in the prevention, diagnosis, and/or treatment of disease are provided. The multivalent binding proteins may contain more than one linked heavy chain and/or light chain variable regions joined by a constant region to an Fc region. The multivalent binding proteins may bind to a number of cytokines, hormones, growth factors, small molecules or cell surface receptors, including NGF and any of a number of small molecules, growth factors, cytokines, hormones or cell surface receptors.

Abstract translation: 提供了制备工程化多价和多特异性结合蛋白以及使用结合蛋白在预防，诊断和/或治疗疾病中的方法。 多价结合蛋白可以含有多个连接的重链和/或轻链可变区，其通过恒定区连接到Fc区。 多价结合蛋白可以结合许多细胞因子，激素，生长因子，小分子或细胞表面受体，包括NGF和许多小分子，生长因子，细胞因子，激素或细胞表面受体中的任何一种。

公开(公告)号：EP2635694A4

公开(公告)日：2015-11-11

申请号：EP11838670

申请日：2011-11-01

Applicant: ABBOTT LAB

Inventor： GHAYUR TARIQ ,  LIU JUNJIAN ,  GU JIJIE ,  HARRIS MARIA C

IPC: C07K16/46 ,  A61K39/395 ,  C07K16/00 ,  C07K16/22 ,  C07K16/24 ,  C07K16/26 ,  C12P21/08

CPC classification number: C07K16/468 ,  A61K2039/505 ,  C07K16/22 ,  C07K16/241 ,  C07K16/26 ,  C07K16/2863 ,  C07K16/2875 ,  C07K2317/24 ,  C07K2317/31 ,  C07K2317/33 ,  C07K2317/567 ,  C07K2317/60 ,  C07K2317/64 ,  C07K2317/71 ,  C07K2317/73 ,  C07K2317/76 ,  C07K2317/92 ,  C07K2317/94

Abstract: Engineered multivalent and multispecific binding proteins, methods of making, and their uses in the prevention, diagnosis, and/or treatment of disease are provided.

公开(公告)号：WO2012088302A3

公开(公告)日：2012-10-11

申请号：PCT/US2011066557

申请日：2011-12-21

Applicant: ABBOTT LAB ,  GHAYUR TARIQ ,  GU JIJIE ,  LIU JUNJIAN ,  HUTCHINS CHARLES W

Inventor： GHAYUR TARIQ ,  GU JIJIE ,  LIU JUNJIAN ,  HUTCHINS CHARLES W

IPC: A61K39/395 ,  C12P21/08

CPC classification number: C07K16/2863 ,  C07K16/00 ,  C07K16/2803 ,  C07K16/2809 ,  C07K16/2818 ,  C07K16/468 ,  C07K2317/31 ,  C07K2317/52 ,  C07K2317/55 ,  C07K2317/60 ,  C07K2317/64 ,  C07K2317/92 ,  C07K2317/94 ,  C07K2319/00

Abstract: The invention provides compositions, methods, and kits related to half-Ig binding proteins that include a functional antibody binding site and a CH3 domain wherein the CH3 domain includes at least one mutation to inhibit CH3-CH3 dimerization.

Abstract translation: 本发明提供了与包含功能性抗体结合位点和CH3结构域的半-Ig结合蛋白有关的组合物，方法和试剂盒，其中CH3结构域包含至少一个抑制CH3-CH3二聚化的突变。

公开(公告)号：WO2012018790A4

公开(公告)日：2012-07-12

申请号：PCT/US2011046233

申请日：2011-08-02

Applicant: ABBOTT LAB ,  GHAYUR TARIQ ,  LIU JUNJIAN ,  ISAKSON PETER C

Inventor： GHAYUR TARIQ ,  LIU JUNJIAN ,  ISAKSON PETER C

IPC: C07K16/00

CPC classification number: C07K16/244 ,  A61K39/3955 ,  A61K45/06 ,  A61K47/6845 ,  A61K49/00 ,  A61K51/1021 ,  C07K16/241 ,  C07K16/245 ,  C07K16/468 ,  C07K2317/35 ,  C07K2317/76 ,  C07K2317/92 ,  C07K2317/94 ,  G01N33/53 ,  G01N33/56966 ,  G01N33/6857 ,  G01N33/6869 ,  G01N2333/54 ,  G01N2333/545 ,  G01N2800/24 ,  G01N2800/7028

Abstract: Engineered multivalent and multispecific binding proteins, methods of making, and their uses in the prevention, diagnosis, and/or treatment of disease are provided.

Abstract translation: 提供了工程化的多价和多特异性结合蛋白，制备方法及其在预防，诊断和/或治疗疾病中的用途。

公开(公告)号：WO2011047262A3

公开(公告)日：2011-09-09

申请号：PCT/US2010052843

申请日：2010-10-15

Applicant: ABBOTT LAB ,  GHAYUR TARIQ ,  KAMATH RAJESH V ,  LIU JUNJIAN ,  HONORE MARIE P

Inventor： GHAYUR TARIQ ,  KAMATH RAJESH V ,  LIU JUNJIAN ,  HONORE MARIE P

IPC: C12P21/08 ,  C12Q1/70

CPC classification number: C07K16/00 ,  C07K16/22 ,  C07K16/241 ,  C07K16/245 ,  C07K16/2866 ,  C07K16/44 ,  C07K16/46 ,  C07K2317/21 ,  C07K2317/31 ,  C07K2317/56 ,  C07K2317/73 ,  C07K2317/76

Abstract: The present invention relates to engineered multivalent and multispecific binding proteins, methods of making, and specifically to their uses in the prevention, diagnosis, and/or treatment of disease.

公开(公告)号：WO2010127284A2

公开(公告)日：2010-11-04

申请号：PCT/US2010033231

申请日：2010-04-30

Applicant: ABBOTT LAB ,  GHAYUR TARIQ ,  LIU JUNJIAN ,  KINGSBURY GILLIAN A ,  REILLY EDWARD B ,  MORGAN-LAPPE SUSAN E

Inventor： GHAYUR TARIQ ,  LIU JUNJIAN ,  KINGSBURY GILLIAN A ,  REILLY EDWARD B ,  MORGAN-LAPPE SUSAN E

IPC: A61K39/395 ,  C12P21/06

CPC classification number: C07K16/2863 ,  A61K39/3955 ,  A61K39/39558 ,  A61K45/06 ,  A61K47/6879 ,  A61K2039/505 ,  C07K16/22 ,  C07K16/28 ,  C07K16/2809 ,  C07K16/40 ,  C07K16/468 ,  C07K2317/24 ,  C07K2317/31 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/64 ,  C07K2317/76 ,  C07K2317/92 ,  C07K2319/00 ,  G01N33/74 ,  G01N2333/71

Abstract: The present invention relates to engineered multivalent and multispecific binding proteins, methods of making, and specifically to their uses in the prevention, diagnosis, and/or treatment of disease.

公开(公告)号：WO2012061374A3

公开(公告)日：2012-11-01

申请号：PCT/US2011058769

申请日：2011-11-01

Applicant: ABBOTT LAB ,  GHAYUR TARIQ ,  LIU JUNJIAN ,  GU JIJIE ,  HARRIS MARIA C

Inventor： GHAYUR TARIQ ,  LIU JUNJIAN ,  GU JIJIE ,  HARRIS MARIA C

IPC: C12P21/08 ,  A61K39/395 ,  C07K16/00

CPC classification number: C07K16/468 ,  A61K2039/505 ,  C07K16/22 ,  C07K16/241 ,  C07K16/26 ,  C07K16/2863 ,  C07K16/2875 ,  C07K2317/24 ,  C07K2317/31 ,  C07K2317/33 ,  C07K2317/567 ,  C07K2317/60 ,  C07K2317/64 ,  C07K2317/71 ,  C07K2317/73 ,  C07K2317/76 ,  C07K2317/92 ,  C07K2317/94

Abstract: Engineered multivalent and multispecific binding proteins, methods of making, and their uses in the prevention, diagnosis, and/or treatment of disease are provided.

Abstract translation: 提供了工程化的多价和多特异性结合蛋白，制备方法以及它们在疾病的预防，诊断和/或治疗中的用途。

公开(公告)号：WO2011163478A3

公开(公告)日：2012-05-03

申请号：PCT/US2011041633

申请日：2011-06-23

Applicant: ABBOTT LAB ,  GHAYUR TARIQ ,  LIU JUNJIAN ,  JAKWAY JAMES J ,  TALANIAN ROBERT V ,  BENATUIL LORENZO

Inventor： GHAYUR TARIQ ,  LIU JUNJIAN ,  JAKWAY JAMES J ,  TALANIAN ROBERT V ,  BENATUIL LORENZO

IPC: A61K39/395 ,  C07K16/00 ,  C12P21/02

CPC classification number: C07K16/2875 ,  C07K16/241 ,  C07K16/468 ,  C07K2317/31 ,  C07K2317/64

Abstract: The present invention relates to engineered multivalent and multispecific binding proteins, methods of making, and specifically to their uses in the prevention, diagnosis, and/or treatment of disease.