公开(公告)号：WO02070554A3

公开(公告)日：2003-03-20

申请号：PCT/US0205152

申请日：2002-02-19

Applicant: ABBOTT LAB

Inventor： LUO YAN ,  GIRANDA VINCENT L

IPC: C07K14/47 ,  C12N15/12 ,  A61K31/7088 ,  C07K16/18 ,  C12N15/11 ,  C12Q1/68 ,  G01N33/53

CPC classification number: C07K14/47 ,  A61K2039/53

Abstract: An isolated and purified nucleic acid sequence encoding the human homolog of Schizosaccharomyces pombe Cid2 is disclosed.

Abstract translation: 公开了一种分离和纯化的编码粟酒裂殖酵母萌发萌发的人类同系物的核酸序列。

公开(公告)号：WO0168837A3

公开(公告)日：2002-04-04

申请号：PCT/US0106950

申请日：2001-03-02

Applicant: ABBOTT LAB

Inventor： LUO YAN ,  GIRANDA VINCENT L ,  ROCKOW-MAGNONE SHAYNA K

IPC: G01N33/50 ,  A61K31/7088 ,  A61K35/76 ,  A61K38/00 ,  A61K48/00 ,  A61P35/00 ,  A61P43/00 ,  C12N15/09 ,  C12N15/113 ,  C12Q1/02 ,  C12Q1/68 ,  G01N33/15 ,  C12N15/11 ,  C07H21/00 ,  C12N5/10 ,  C12N9/00

CPC classification number: C12N15/1137 ,  A61K38/00 ,  C12N2310/111

Abstract: The subject invention relates to antisense oligonucleotides of the human Chk1 gene and to uses thereof. The human ChK1 gene is a major G2/M checkpoint gene that is activated in response to DNA damage. In particular, the gene transduces the inhibitory signal from DNA damage sensors to the basic cell cycle machinery. Thus, antisense oligonucleotides to the human Chk1 gene may be used, for example, to inhibit the gene thereby preventing G2 arrest induced by DNA damaging agents. Such antisense oligonucleotides should also further sensitize tumor cells thereby making them more sensitive to therapy than normal cells.

Abstract translation: 本发明涉及人Chk1基因的反义寡核苷酸及其应用。 人类ChK1基因是一个主要的G2 / M检查点基因，其被激活以响应DNA损伤。 特别地，该基因将来自DNA损伤传感器的抑制信号转导至基本细胞周期机制。 因此，可以使用人Chk1基因的反义寡核苷酸，例如抑制基因，从而防止由DNA损伤剂诱导的G2阻滞。 这样的反义寡核苷酸还应该进一步使肿瘤细胞敏感，从而使它们比正常细胞对治疗更敏感。

公开(公告)号：CA2402041A1

公开(公告)日：2001-09-20

申请号：CA2402041

申请日：2001-03-02

Applicant: ABBOTT LAB

Inventor： LUO YAN ,  GIRANDA VINCENT L ,  ROCKOW-MAGNONE SHAYNA K

IPC: G01N33/50 ,  A61K31/7088 ,  A61K35/76 ,  A61K38/00 ,  A61K48/00 ,  A61P35/00 ,  A61P43/00 ,  C12N15/09 ,  C12N15/113 ,  C12Q1/02 ,  C12Q1/68 ,  G01N33/15 ,  C12N15/11 ,  C07H21/00 ,  C12N9/00 ,  C12N5/10

Abstract: The subject invention relates to antisense oligonucleotides of the human Chk1 gene and to uses thereof. The human ChK1 gene is a major G2/M checkpoint gene that is activated in response to DNA damage. In particular, the gene transduces the inhibitory signal from DNA damage sensors to the basic cell cycle machinery. Thus, antisense oligonucleotides to the human Chk1 gene may be used, for example, to inhibit the gene thereby preventing G2 arrest induced by DNA damaging agents. Such antisense oligonucleotides should also further sensitize tumor cells thereby making them more sensitive to therapy than normal cells.