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    CNS ACTIVE FUSED BICYCLOHETEROCYCLE SUBSTITUTED AZABICYCLIC ALKANE DERIVATIVES
    2.
    发明申请
    CNS ACTIVE FUSED BICYCLOHETEROCYCLE SUBSTITUTED AZABICYCLIC ALKANE DERIVATIVES 审中-公开
    中枢神经系统活性融合的双环蛋白取代的亚氨基烷烃衍生物

    公开(公告)号：WO2007137030A3

    公开(公告)日：2008-07-24

    申请号：PCT/US2007068930

    申请日：2007-05-15

    Applicant: ABBOTT LAB ,  JI JIANGUO ,  LI TAO ,  LYNCH CHRISTOPHER L ,  GOPALAKRISHNAN MURALI

    Inventor： JI JIANGUO ,  LI TAO ,  LYNCH CHRISTOPHER L ,  GOPALAKRISHNAN MURALI

    IPC: C07D451/08 ,  A61K31/4375 ,  A61P25/00 ,  C07D451/14 ,  C07D519/00

    CPC classification number: C07D451/08 ,  C07D451/14 ,  C07D519/00

    Abstract: The invention relates to fused bicycloheterocycle substituted azabicyclic alkane derivatives of formula (I), or a pharmaceutically acceptable salt, ester, amid, or prodrug thereof, wherein n is 1, 2 or 3; A is N or N + -O - ; R is hydrogen, alkyl, cycloalkylalkyl and arylalkyl; L is selected from the group consisting of O, S, and -N(R a )-; Ar 1 is a 6-membered aryl or 6 membered heteroaryl ring; and Ar 2 is a bicyclic heteroaryl; and R a is selected from the group consisting of hydrogen, alkyl and alkylcarbonyl; provided that if Ar 1 is Formula (II), then L is O or S. Compositions comprising such compounds, and methods of treating conditions and disorders using such compounds and compositions.

    Abstract translation: 本发明涉及式（I）的稠合双环杂环取代的氮杂双环烷烃衍生物或其药学上可接受的盐，酯，酰胺或前药，其中n为1,2或3; A是N或N + O - - O - R是氢，烷基，环烷基烷基和芳基烷基; L选自O，S和-N（R a）a）。 Ar 1是6元芳基或6元杂芳基环; 且Ar 2是双环杂芳基; 且R a a选自氢，烷基和烷基羰基; 条件是如果Ar 1是式（II），则L是O或S.包含这些化合物的组合物，以及使用这些化合物和组合物治疗病症和障碍的方法。

    CNS ACTIVE FUSED BICYCLOHETEROCYCLE SUBSTITUTED AZABICYCLIC ALKANE DERIVATIVES
    7.
    发明专利
    CNS ACTIVE FUSED BICYCLOHETEROCYCLE SUBSTITUTED AZABICYCLIC ALKANE DERIVATIVES 未知

    公开(公告)号：NZ573735A

    公开(公告)日：2011-10-28

    申请号：NZ57373507

    申请日：2007-05-15

    Applicant: ABBOTT LAB

    Inventor： JI JIANGUO ,  LI TAO ,  LYNCH CHRISTOPHER L ,  GOPALAKRISHNAN MURALI

    IPC: C07D451/08 ,  A61K31/4375 ,  A61P25/00 ,  C07D451/14 ,  C07D519/00

    Abstract: Disclosed is the aza-bicyclo[3.2.1]oct-3-yloxy compound of formula (I) or a pharmaceutically acceptable salt, ester or amide thereof, wherein n is 1, 2 or 3; A is N or N+-O-; R is hydrogen, alkyl, cycloalkylalkyl and arylallcyl; L is selected from the group consisting of O, S, and -N(Ra)-; Ar1 is a 6-membered 6 membered ring; and Ar2 is a fused nine-membered bicyclic heteroaryl; and Ra is selected from the group consisting of hydrogen, alkyl and alkylcarbonyl for treating or preventing a condition or disorder selected from the group consisting of attention deficit disorder, attention deficit hyperactivity disorder (ADHD), Alzheimer's disease (AD), mild cognitive impairment, senile dementia, AIDS dementia, Pick's Disease, dementia associated with Lewy bodies, dementia associated with Down's syndrome, arnyotrophic lateral sclerosis, Huntington's disease, diminished CNS function associated with traumatic brain injury, acute pain, post-surgical pain, chronic pain, inflammation, inflammatory pain, neuropathic pain, infertility, need for new blood vessel growth associated with wound healing, need for new blood vessel growth associated with vascularization of skin grafts, and lack of circulation, rheumatoid arthritis, Crohn's disease, ulcerative colitis, inflammatory bowel disease, organ transplant rejection, acute immune disease associated with organ transplantation, chronic immune disease associated with organ transplantation, septic shock, toxic shock syndrome, sepsis syndrome, depression, and rheumatoid spondylitis.

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