公开(公告)号：JPH0276823A

公开(公告)日：1990-03-16

申请号：JP13295389

申请日：1989-05-29

Applicant: ABBOTT LAB

Inventor： POORU POOUEN HANGU ,  RANAJITSUTO ROIKOODOHARII ,  MAIKERU CHIENGUUIEN CHIEN ,  SHIYAUUGANGU RII ,  BERII JIYOSEFU RAZUKIN ,  UIRII YUUGEN SUKORENKU

IPC: A61K38/04 ,  A61K38/46 ,  A61P7/02 ,  C07H21/00 ,  C07H21/04 ,  C07K14/745 ,  C12N1/14 ,  C12N1/18 ,  C12N1/20 ,  C12N1/21 ,  C12N9/64 ,  C12N9/72 ,  C12N15/00 ,  C12N15/09 ,  C12P21/00 ,  C12R1/19 ,  C12R1/91

Abstract: PURPOSE: To obtain a thrombolytic agent comprising, as an active ingredient, a plasminogen activator protein product expressed by a polydeoxyribonucleotide segment coding a plasminogen activator protein and substantially having characteristics of urokinase. CONSTITUTION: This thrombolytic agent comprises, as an active ingredient, a plasminogen activator protein product expressed by a polydeoxyribonucleotide segment coding a plasminogen activator protein and substantially having characteristics of urokinase and has activities similar to that of naturally derived urokinase which is expensive in the production cost even when tissue culture is used. Furthermore, the active ingredient can be produced by a method similar to that of antibiotic compounds obtained by introducing modified plasmid in which a deoxyribonucleic acid coding a plasminogen activator concerning human urokinase is integrated into bacteria or other microorganisms and culturing these microorganisms.

公开(公告)号：JPH06315379A

公开(公告)日：1994-11-15

申请号：JP5652694

申请日：1994-02-17

Applicant: ABBOTT LAB

Inventor： POORU POOUEN HANGU ,  RANAJITSUTO ROIKOODOHARII ,  MAIKERU CHIENGUUIEN CHIEN ,  SHIYAUUGANGU RII ,  BERII JIYOSEFU RAZUKIN ,  UIRII YUUGEN SUKORENKU

IPC: A61K38/04 ,  A61K38/46 ,  A61P7/02 ,  C07H21/00 ,  C07H21/04 ,  C07K14/745 ,  C12N1/14 ,  C12N1/18 ,  C12N1/20 ,  C12N1/21 ,  C12N9/64 ,  C12N9/72 ,  C12N15/00 ,  C12N15/09 ,  C12P21/00 ,  C12R1/19 ,  C12R1/91 ,  C12N15/58

公开(公告)号：JPH0284186A

公开(公告)日：1990-03-26

申请号：JP13295289

申请日：1989-05-29

Applicant: ABBOTT LAB

Inventor： POORU POOUEN HANGU ,  RANAJITSUTO ROIKOODOHARII ,  MAIKERU CHIENGUUIEN CHIEN ,  SHIYAUUGANGU RII ,  BERII JIYOSEFU RAZUKIN ,  UIRII YUUGEN SUKORENKU

IPC: A61K38/04 ,  A61K38/46 ,  A61P7/02 ,  C07H21/00 ,  C07H21/04 ,  C07K14/745 ,  C12N1/14 ,  C12N1/18 ,  C12N1/20 ,  C12N1/21 ,  C12N9/64 ,  C12N9/72 ,  C12N15/00 ,  C12N15/09 ,  C12P21/00 ,  C12R1/19 ,  C12R1/91

Abstract: The present invention provides a deoxyribonucleic acid (DNA) segment related to a human plasminogen activator gene. The segment is inserted into a plasmid vector which in turn can be incorporated into a bacterium or other microorganism. The bacterium can then be cultured to produce a plasminogen activator protein having properties of human urokinase.

公开(公告)号：JPH07132085A

公开(公告)日：1995-05-23

申请号：JP5652594

申请日：1994-02-17

Applicant: ABBOTT LAB

Inventor： POORU POOUEN HANGU ,  RANAJITSUTO ROIKOODOHARII ,  MAIKERU CHIENGUUIEN CHIEN ,  SHIYAUUGANGU RII ,  BERII JIYOSEFU RAZUKIN ,  UIRII YUUGEN SUKORENKU

IPC: A61K38/04 ,  A61K38/46 ,  A61P7/02 ,  C07H21/00 ,  C07H21/04 ,  C07K14/745 ,  C12N1/14 ,  C12N1/18 ,  C12N1/20 ,  C12N1/21 ,  C12N9/64 ,  C12N9/72 ,  C12N15/00 ,  C12N15/09 ,  C12P21/00 ,  C12R1/19 ,  C12R1/91

公开(公告)号：JPS56158799A

公开(公告)日：1981-12-07

申请号：JP4949281

申请日：1981-04-03

Applicant: ABBOTT LAB

Inventor： POORU POOUEN HANGU ,  RANAJITSUTO ROIKOODOHARII ,  MAIKERU CHIENGUUIEN CHIEN ,  SHIYAUUGANGU RII ,  BERII JIYOSEFU RAZUKIN ,  UIRII YUUGEN SUKORENKU

IPC: A61K38/04 ,  A61K38/46 ,  A61P7/02 ,  C07H21/00 ,  C07H21/04 ,  C07K14/745 ,  C12N1/14 ,  C12N1/18 ,  C12N1/20 ,  C12N1/21 ,  C12N9/64 ,  C12N9/72 ,  C12N15/00 ,  C12N15/09 ,  C12P21/00 ,  C12R1/19 ,  C12R1/91