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    Sustained release dosage form unit having latex coating and method of making the same
    1.
    发明专利
    Sustained release dosage form unit having latex coating and method of making the same 审中-公开
    具有LATEX涂层的持续释放剂型单元及其制备方法

    公开(公告)号：JP2012144542A

    公开(公告)日：2012-08-02

    申请号：JP2012047597

    申请日：2012-03-05

    Applicant: Abbott Lab ,  アボット・ラボラトリーズAbbott Laboratories

    Inventor： MAZER TERRY B ,  WALTON JOSEPH E ,  ARNHOLT BARBARA S ,  EVANS MONTY L ,  GECKLE RONITA K ,  HAMILTON DANIEL ,  KROPCZYNSKI JOHN J JR ,  MURAWSKI FRANKA A ,  TUCKER LARRY G ,  WALKER SHERRI A ,  WALSH MICHAEL V ,  WALSH RHONDA E

    IPC: A61K9/28 ,  A61J3/06 ,  A61K9/20 ,  A61K9/30 ,  A61K9/34 ,  A61K9/36 ,  A61K47/02 ,  A61K47/10 ,  A61K47/12 ,  A61K47/14 ,  A61K47/36 ,  A61K47/38 ,  A61K49/00

    CPC classification number: A61K9/286 ,  A61K9/2054 ,  A61K9/209 ,  A61K9/2866

    Abstract: PROBLEM TO BE SOLVED: To provide a dosage form unit to deliver one or more beneficial agents into a fluid, such as a liquid enteral nutritional product, and a method of making the same.SOLUTION: The dosage form unit includes a core containing at least one beneficial agent, preferably a marker dye, which is dispersible in the fluid. The core also contains a compatible binding agent to bind the beneficial agent together. Additional components of the core may include a plasticizer, a standard flow agent, a lubricant, additional tableting aids and at least one hydrophilic agent. A latex coating encases the core. The latex coating includes a mixture containing a substantially hydrophobic base material, preferably formed from an emulsion of cellulose acetate microspheres, which is capable of defining a matrix-type membrane, and at least one hydrophilic component being dispersible in the fluid. The dispersible beneficial agent is preferred as one of the hydrophilic components of the latex coating to allow immediate release of the beneficial agent therefrom.

    Abstract translation: 待解决的问题：提供一种剂型单元以将一种或多种有益剂递送到流体中，例如液体肠内营养产品及其制备方法。 解决方案：剂型单元包括含有至少一种可分散在流体中的有益剂，优选标记染料的芯。 核心还含有一种相容的结合剂以将有益剂结合在一起。 芯的另外的组分可以包括增塑剂，标准流动剂，润滑剂，另外的压片助剂和至少一种亲水剂。 乳胶涂层包裹核心。 胶乳涂层包括含有基本上疏水的基材的混合物，优选由乙酸纤维素微球的乳液形成，其能够限定基质型膜，以及至少一种可分散在流体中的亲水组分。 可分散的有益剂优选作为胶乳涂层的亲水组分之一，以允许从其中立即释放有益剂。 版权所有（C）2012，JPO＆INPIT

    COMPOSITIONS FOR IMPROVING BREAST HEALTH IN WOMAN
    5.
    发明专利
    COMPOSITIONS FOR IMPROVING BREAST HEALTH IN WOMAN 未知

    公开(公告)号：CA2564592A1

    公开(公告)日：2005-12-08

    申请号：CA2564592

    申请日：2005-04-28

    Applicant: ABBOTT LAB

    Inventor： MAZER TERRY B ,  DEWILLE NORMANELLA T ,  SETH ANAND ,  DAS TAPAS ,  SHALWITZ ROBERT A ,  RUSHLOW KEITH E

    IPC: A61K31/202 ,  A23L1/30 ,  A23L1/304 ,  A23L33/00 ,  A61K33/04 ,  A61K33/18 ,  A61K45/06 ,  A61P39/00

    Abstract: Disclosed are compositions and corresponding methods for treating fibrocysti c breast disease or other breast-related disease or condition. The composition s comprise, per serving or dose, from zero to about 400 ~g selenium, from abou t 100 mg to about 6000 mg gamma linolenic acid, and about 0.15mg to about 5 mg iodine, with nutritional embodiments further comprising one or more of protein, fat, carbohydrate, vitamins, and minerals and providing from about 50 to about 1000 kcal of energy per severing or dose. Also disclosed are in-vit ro studies showing that certain combinations of gamma linolenic acid, iodine, and/or selenium may 1) inhibit breast cancer or fibrocystic cell proliferation, 2) reinforce the function of tight junctions of endothelial cells and of mammary epithelial cells in estrogen-sensitive conditions, and 3) reduce the risk of vascular invasion by breast cancer cells.

    6.
    发明专利
    未知

    公开(公告)号：AT303796T

    公开(公告)日：2005-09-15

    申请号：AT00946882

    申请日：2000-06-28

    Applicant: ABBOTT LAB

    Inventor： MAZER TERRY B ,  WALTON JOSEPH E ,  ARNHOLT BARBARA S ,  EVANS MONTY L ,  GECKLE RONITA K ,  HAMILTON DANIEL ,  KROPCZYNSKI JOHN J JR ,  MURAWSKI FRANKA A ,  TUCKER LARRY G ,  WALKER SHERRI A ,  WALSH MICHAEL V ,  WALSH RHONDA E

    IPC: A61K9/20 ,  A61K9/28 ,  A61K9/30 ,  A61K9/34 ,  A61K9/36 ,  A61K47/38

    Abstract: Dosage form unit is provided to deliver one or more beneficial agents into a fluid, such as liquid enteral nutritional product. The dosage form unit includes a core containing at least one beneficial agent, preferably a marker dye, which is dispersible in the fluid. The core also contains a compatible binding agent to bind the beneficial agent together. Additional components of the core may include a plasticizer, a standard flow agent, a lubricant, additional tableting aids and at least one hydrophilic agent. A latex coating encases the core. The latex coating includes a mixture containing a substantially hydrophobic base material, preferably formed from an emulsion of cellulose acetate microspheres, which is capable of defining a matrix-type membrane, and at least one hydrophilic component being dispersible in the fluid. A dispersible beneficial agent is preferred as one of the hydrophilic components of the latex coating to allow immediate release of the beneficial agent therefrom. A method of making the dosage form unit also is provided.

    EMULSIONES NUTRICIONALES ENFRIADAS
    8.
    发明专利
    EMULSIONES NUTRICIONALES ENFRIADAS 未知

    公开(公告)号：PE20091170A1

    公开(公告)日：2009-09-03

    申请号：PE2008002121

    申请日：2008-12-18

    Applicant: ABBOTT LAB

    Inventor： WALTON JOSEPH E ,  LAI CHRON-SI ,  LUI JIM-WIN R ,  DRAPER KATI E ,  STEPP EMILY A ,  MAZER TERRY B

    IPC: A23L1/304 ,  A23L1/305 ,  A23L29/10 ,  A23L33/00 ,  A23L33/15

    Abstract: SE REFIERE A EMULSIONES CARACTERIZADAS PORQUE COMPRENDEN LIPIDOS, PROTEINAS Y CARBOHIDRATOS QUE INCLUYEN UN COMPLEJO-V QUE COMPRENDE UN TENSIOACTIVO DE GRADO ALIMENTICIO TAL COMO MONOGLICEROL C12 EN 0,001-5% EN PESO CON UNA POLIDEXTROSA TAL COMO MALTODEXTRINA EN 1-5% EN PESO, CON UN GRADO DE POLIMERIZACION DE 10. DICHA EMULSION NUTRICIONAL CONTIENE ENTRE 0,1-2,0 GRAMOS DE LIPIDOS POR 100 mL DE LA EMULSION. TAMBIEN SE REFIERE A UN METODO DE PREPARACION PARA LA EMULSION NUTRICIONAL, ENVASADA A UNA ESTERILIZACION EN AUTOCLAVE, CARACTERIZADA POR DESARROLLAR UNA CONSISTENCIA ESPESA Y CREMOSA EN FRIO ANTES DE SU USO, SIENDO DE UTILIDAD EN LA FABRICACION DE BEBIDAS NUTRICIONALES

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