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    DUAL VARIABLE DOMAIN IMMUNOGLOBULINS AND USES THEREOF
    3.
    发明专利
    DUAL VARIABLE DOMAIN IMMUNOGLOBULINS AND USES THEREOF 未知

    公开(公告)号：NZ589436A

    公开(公告)日：2012-12-21

    申请号：NZ58943609

    申请日：2009-06-03

    Applicant: ABBOTT LAB

    Inventor： GHAYUR TARIQ ,  HAHN ALFRED ,  MUELLER BERNHARD

    IPC: C07K16/20 ,  C07K16/46 ,  C12P21/08

    Abstract: Provided is a binding protein comprising first and second polypeptide chains, wherein said first polypeptide chain comprises a first VD1-(X1)n-VD2-C-(X2)n, wherein VD1 is a first heavy chain variable domain; VD2 is a second heavy chain variable domain; C is a heavy chain constant domain; X1 is a linker with the proviso that it is not CHI; X2 is an Fc region; n is 0 or 1; and wherein said second polypeptide chain comprises a second VD1-(X1)n-VD2-C-(X2)n, wherein VD1 is a first light chain variable domain; VD2 is a second light chain variable domain; C is a light chain constant domain; X1 is a linker with the proviso that it is not CHI; X2 does not comprise an Fc region; n is 0 or 1; and wherein the binding protein is capable of binding: TNF-alpha and RAGE, wherein the light and heavy chain variable domains have specified sequences. The dual-domain antibodies can be used to treat arthritis and other inflammatory diseases such as colitis, asthma, psoriasis and others.

    INMUNOGLOBULINA CON DOMINIO VARIABLE DUAL
    7.
    发明专利
    INMUNOGLOBULINA CON DOMINIO VARIABLE DUAL 未知

    公开(公告)号：PE20100054A1

    公开(公告)日：2010-03-03

    申请号：PE2009000770

    申请日：2009-06-03

    Applicant: ABBOTT LAB

    Inventor： GHAYUR TARIQ ,  HAHN ALFRED ,  MUELLER BERNHARD

    IPC: C07K16/00 ,  C12N1/19 ,  C12N1/21 ,  C12N5/10 ,  C12N9/99 ,  C12N15/63

    Abstract: REFERIDA A UNA PROTEINA DE UNION QUE COMPRENDE UNA CADENA POLIPEPTIDICA VD1-(X1)n-VD2-C-(X2)n, DONDE VD1 ES UN PRIMER DOMINIO VARIABLE DE CADENA PRESADA Y VD2 ES UN SEGUNDO DOMINIO VARIABLE DE CADENA PESADA QUE COMPRENDEN UNA SECUENCIA DE AMINOACIDOS SELECCIONADA DE SEQ ID NO: 28, 30, 32, 34, 36, 38, 40, 42, 44, 46, 48, 50, 52, 54 Y 56; C ES UN DOMINIO CONSTANTE DE LA CADENA PESADA; X1 ES UN CONECTOR, CON LA CONDICION DE QUE NO SEA CH1; X2 ES UNA REGION Fc DE SECUENCIA VARIANTE; n ES 0 O 1. TAMBIEN ESTA REFERIDA A UN VECTOR, UNA CELULA HUESPED, UN PROCEDIMIENTO DE PREPARACION Y UNA COMPOSICION FARMACEUTICA. DICHA PROTEINA DE UNION ES UTIL EN EL TRATAMIENTO DE ENFERMEDADES INFLAMATORIAS AGUDAS Y CRONICAS, CANCER, ENTRE OTRAS

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