公开(公告)号：NZ218936A

公开(公告)日：1989-10-27

申请号：NZ21893687

申请日：1987-01-14

Applicant: ABBOTT LAB

Inventor： LULY J R ,  PLATTNER J J ,  KEMPF D J

IPC: C07C215/10 ,  A61K31/16 ,  A61K31/165 ,  A61K31/18 ,  A61K31/215 ,  A61K31/22 ,  A61K31/255 ,  A61K31/33 ,  A61K31/535 ,  A61K31/5375 ,  A61K38/00 ,  A61P9/12 ,  A61P43/00 ,  C07C67/00 ,  C07C213/00 ,  C07C215/20 ,  C07C215/26 ,  C07C215/28 ,  C07C217/44 ,  C07C231/00 ,  C07C231/12 ,  C07C235/06 ,  C07C235/08 ,  C07C235/10 ,  C07C235/74 ,  C07C237/08 ,  C07C237/10 ,  C07C237/22 ,  C07C239/00 ,  C07C269/00 ,  C07C271/16 ,  C07C273/10 ,  C07C301/00 ,  C07C303/30 ,  C07C303/40 ,  C07C309/63 ,  C07C311/00 ,  C07C313/00 ,  C07C323/60 ,  C07D233/54 ,  C07D233/64 ,  C07D241/24 ,  C07D295/18 ,  C07D521/00 ,  C07K1/113 ,  C07K5/02 ,  C07K5/06 ,  C07K5/065 ,  C07K5/083 ,  C07K5/097 ,  C07K14/81 ,  C12N9/99 ,  C07K5/08 ,  A61K37/64

Abstract: A renin inhibiting compound of the formula: wherein A is a substituent; W is C=O or CHOH; U is CH2 or NR2, provided that when W is CHOH then U is CH2; R1 is loweralkyl, cycloalkylmethyl, benzyl, 4-methoxybenzyl, halobenzyl, (1-naphthyl)methyl, (2-naphthyl)methyl, (4-imidazoyl)methyl, alpha , alpha -dimethylbenzyl, 1-benzyloxyethyl, phenethyl, phenoxy, thiophenoxy or anilino; R2 is hydrogen or loweralkyl; R3 is loweralkyl, [(alkoxy)alkoxy]alkyl, (thioalkoxy)alkyl, lowerakenyl, benzyl or heterocyclic ring substituted methyl; R4 is loweralkyl, cycloalkylmethyl or benzyl; R5 is vinyl, formyl, hydroxymethyl or hydrogen; R7 is hydrogen or loweralkyl; R8 and R9 are independently selected from OH and NH2; and R6 is hydrogen, loweralkyl, vinyl or arylalkyl; provided that when R5 and R7 are both hydrogen and R8 and R9 are OH, the carbon bearing R5 is of the "R" configuration and the carbon bearing R6 is of the "S" configuration; or pharmaceutically acceptable salts or esters thereof. Also disclosed are renin inhibiting compositions, a method of treating hypertension, methods of making the renin inhibiting compounds and intermediates useful in making the renin inhibiting compounds.

公开(公告)号：NZ214974A

公开(公告)日：1989-02-24

申请号：NZ21497486

申请日：1986-01-29

Applicant: ABBOTT LAB

Inventor： LULY J R ,  ROSENBERG S H ,  PLATTNER J J ,  FUNG A K L

IPC: A61K31/395 ,  A61K31/47 ,  A61K31/55 ,  C07D217/00 ,  C07D217/20 ,  C07K5/08 ,  A61K37/02 ,  C07C103/00 ,  C07C103/20

公开(公告)号：NZ204787A

公开(公告)日：1986-03-14

申请号：NZ20478783

申请日：1983-07-01

Applicant: ABBOTT LAB

Inventor： PLATTNER J J ,  FUNG A K

IPC: A61K31/42 ,  C07D498/00