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公开(公告)号：DE69011305D1
公开(公告)日：1994-09-08
申请号：DE69011305
申请日：1990-12-21
Applicant: ABBOTT LAB
Inventor： BROOKS DEE W , HORROM BRUCE W , RODRIQUES KAREN E , MAZDIYASNI MAZDIYASNI
IPC: A61K31/16 , A61K31/17 , A61K31/335 , A61K31/357 , A61K31/38 , A61K31/381 , A61K31/40 , A61K31/403 , A61K31/404 , A61K31/425 , A61K31/426 , A61K31/44 , A61K31/4402 , A61K31/4406 , A61K31/4409 , A61K31/4412 , A61K31/4418 , A61K31/443 , A61K31/445 , A61K31/47 , A61K31/495 , A61K31/535 , A61K31/5375 , A61K31/54 , A61P29/00 , A61P43/00 , C07C239/08 , C07C259/06 , C07C259/08 , C07C275/64 , C07D207/32 , C07D207/335 , C07D209/14 , C07D213/30 , C07D213/40 , C07D213/42 , C07D213/61 , C07D213/64 , C07D213/643 , C07D213/65 , C07D213/68 , C07D215/12 , C07D239/26 , C07D277/28 , C07D277/34 , C07D277/64 , C07D295/20 , C07D307/52 , C07D307/56 , C07D307/58 , C07D307/81 , C07D307/83 , C07D317/58 , C07D319/18 , C07D333/16 , C07D333/20 , C07D333/28 , C07D333/32 , C07D333/56 , C07D333/58 , C07D333/64 , C07D405/04 , C07D409/04 , C07C259/04 , C07D213/24
Abstract: Certain carbocyclic aryl- and heterocyclic aryl- substituted cyclopropyl N-hydroxyureas, N-hydroxy-carboxamides, and N-acyl-N-hydroxyamines inhibit 5- and/or 12-lipoxygenase and are useful in the treatment of inflammatory disease states.
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公开(公告)号：IE64484B1
公开(公告)日：1995-08-09
申请号：IE452390
申请日：1990-12-14
Applicant: ABBOTT LAB
Inventor： BROOKS DEE W , RODRIQUES KAREN E , HORROM BRUCE W , MAZDIYASNI HORMOZ
IPC: A61K31/16 , A61K31/17 , A61K31/335 , A61K31/357 , A61K31/38 , A61K31/381 , A61K31/40 , A61K31/403 , A61K31/404 , A61K31/425 , A61K31/426 , A61K31/44 , A61K31/4402 , A61K31/4406 , A61K31/4409 , A61K31/4412 , A61K31/4418 , A61K31/443 , A61K31/445 , A61K31/47 , A61K31/495 , A61K31/535 , A61K31/5375 , A61K31/54 , A61P29/00 , A61P43/00 , C07C239/08 , C07C259/06 , C07C259/08 , C07C275/64 , C07D207/32 , C07D207/335 , C07D209/14 , C07D213/30 , C07D213/40 , C07D213/42 , C07D213/61 , C07D213/64 , C07D213/643 , C07D213/65 , C07D213/68 , C07D215/12 , C07D239/26 , C07D277/28 , C07D277/34 , C07D277/64 , C07D295/20 , C07D307/52 , C07D307/56 , C07D307/58 , C07D307/81 , C07D307/83 , C07D317/58 , C07D319/18 , C07D333/16 , C07D333/20 , C07D333/28 , C07D333/32 , C07D333/56 , C07D333/58 , C07D333/64 , C07D405/04 , C07D409/04 , C07C259/04 , C07C323/32 , C07D213/24 , C07F7/10
Abstract: Certain carbocyclic aryl- and heterocyclic aryl- substituted cyclopropyl N-hydroxyureas, N-hydroxy-carboxamides, and N-acyl-N-hydroxyamines inhibit 5- and/or 12-lipoxygenase and are useful in the treatment of inflammatory disease states.
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公开(公告)号：CA2090006A1
公开(公告)日：1992-02-21
申请号：CA2090006
申请日：1991-08-07
Applicant: ABBOTT LAB
Inventor： BROOKS DEE W , CARTER GEORGE W , DELLARIA JOSEPH F , MAKI ROBERT G , RODRIQUES KAREN E
IPC: A61K31/40 , A61K31/403 , A61K31/404 , A61K31/41 , A61K31/415 , A61K31/425 , A61K31/44 , A61K31/4427 , A61K31/443 , A61K31/4433 , A61K31/445 , A61K31/47 , A61K31/495 , A61K31/505 , A61P29/00 , A61P37/08 , A61P43/00 , C07D209/22 , C07D209/30 , C07D401/06 , C07D401/12 , C07D405/12 , C07D409/06 , C07D409/12 , C07D417/12 , C07D401/02 , C07D403/02 , C07D405/02 , C07D409/02 , C07D413/02 , C07D417/02 , C07D209/14 , A61K31/435 , A61K31/535
Abstract: 2090006 9203132 PCTABS00010 Substituted indolyl compounds of formula (I) are potent inhibitors of the lipoxygenase enzymes and are useful as agents for the treatment of allergies and inflammatory disease states.
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公开(公告)号：CA2005445A1
公开(公告)日：1990-06-16
申请号：CA2005445
申请日：1989-12-13
Applicant: ABBOTT LAB
Inventor： BROOKS DEE W , RODRIQUES KAREN E
IPC: C12N9/99 , A61K31/19 , A61K31/195 , A61K31/38 , A61K31/381 , A61K31/40 , A61K31/403 , A61K31/4035 , A61K31/404 , A61K31/405 , A61K31/415 , A61K31/42 , A61K31/421 , A61K31/423 , A61K31/425 , A61K31/426 , A61K31/54 , A61K31/5415 , A61P3/00 , A61P11/08 , A61P17/00 , A61P29/00 , A61P37/08 , A61P43/00 , C07C275/64 , C07D207/08 , C07D209/28 , C07D209/40 , C07D209/46 , C07D209/88 , C07D231/04 , C07D263/32 , C07D263/56 , C07D277/20 , C07D277/30 , C07D279/20 , C07D279/22 , C07D333/24 , C07D491/052 , A61K31/17 , C07D209/26
Abstract: Compounds of the formula: I wherein A is CH2; n is 0 or 1; R1 and R2 are independently selected from the group consisting of hydrogen, alkyl, alkenyl, aralkyl and cycloalkyl; Z is the residue from a non-steroidal anti-inflammatory carboxylic acid compound; and M is a pharmaceutically acceptable cation or a metabolically cleavable group; and the pharmaceutically acceptable salts thereof; and a non toxic pharmaceutically acceptable carrier. These compounds are useful as inhibitors of 5-lipoxygenase.
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公开(公告)号：DK0544819T3
公开(公告)日：1996-04-09
申请号：DK91917405
申请日：1991-08-07
Applicant: ABBOTT LAB
Inventor： BROOKS DEE W , DELLARIA JOSEPH F , CARTER GEORGE W , MAKI ROBERT G , RODRIQUES KAREN E
IPC: A61K31/40 , A61K31/403 , A61K31/404 , A61K31/41 , A61K31/415 , A61K31/425 , A61K31/44 , A61K31/4427 , A61K31/443 , A61K31/4433 , A61K31/445 , A61K31/47 , A61K31/495 , A61K31/505 , A61P29/00 , A61P37/08 , A61P43/00 , C07D209/22 , C07D209/30 , C07D401/06 , C07D401/12 , C07D405/12 , C07D409/06 , C07D409/12 , C07D417/12 , C07D209/20 , C07D209/42 , C07D403/06 , C07D405/06 , C07D413/06
Abstract: PCT No. PCT/US91/05621 Sec. 371 Date Feb. 16, 1993 Sec. 102(e) Date Feb. 16, 1993 PCT Filed Aug. 7, 1991 PCT Pub. No. WO92/03132 PCT Pub. Date Mar. 5, 1992.Substituted indolyl compounds of the formulanase enzymes and are useful as agents for the treatment of allergies and inflammatory disease states.
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Patent Agency Ranking
公开(公告)号：AT131051T
公开(公告)日：1995-12-15
申请号：AT91917405
申请日：1991-08-07
Applicant: ABBOTT LAB
Inventor： BROOKS DEE W , CARTER GEORGE W , DELLARIA JOSEPH F , MAKI ROBERT G , RODRIQUES KAREN E
IPC: A61K31/40 , A61K31/403 , A61K31/404 , A61K31/41 , A61K31/415 , A61K31/425 , A61K31/44 , A61K31/4427 , A61K31/443 , A61K31/4433 , A61K31/445 , A61K31/47 , A61K31/495 , A61K31/505 , A61P29/00 , A61P37/08 , A61P43/00 , C07D209/22 , C07D209/30 , C07D401/06 , C07D401/12 , C07D405/12 , C07D409/06 , C07D409/12 , C07D417/12 , C07D209/20 , C07D209/42 , C07D405/06
Abstract: PCT No. PCT/US91/05621 Sec. 371 Date Feb. 16, 1993 Sec. 102(e) Date Feb. 16, 1993 PCT Filed Aug. 7, 1991 PCT Pub. No. WO92/03132 PCT Pub. Date Mar. 5, 1992.Substituted indolyl compounds of the formulanase enzymes and are useful as agents for the treatment of allergies and inflammatory disease states.
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公开(公告)号：ES2060918T3
公开(公告)日：1994-12-01
申请号：ES90125065
申请日：1990-12-21
Applicant: ABBOTT LAB
Inventor： BROOKS DEE W , HORROM BRUCE W , RODRIQUES KAREN E , MAZDIYASNI
IPC: A61K31/16 , A61K31/17 , A61K31/335 , A61K31/357 , A61K31/38 , A61K31/381 , A61K31/40 , A61K31/403 , A61K31/404 , A61K31/425 , A61K31/426 , A61K31/44 , A61K31/4402 , A61K31/4406 , A61K31/4409 , A61K31/4412 , A61K31/4418 , A61K31/443 , A61K31/445 , A61K31/47 , A61K31/495 , A61K31/535 , A61K31/5375 , A61K31/54 , A61P29/00 , A61P43/00 , C07C239/08 , C07C259/06 , C07C259/08 , C07C275/64 , C07D207/32 , C07D207/335 , C07D209/14 , C07D213/30 , C07D213/40 , C07D213/42 , C07D213/61 , C07D213/64 , C07D213/643 , C07D213/65 , C07D213/68 , C07D215/12 , C07D239/26 , C07D277/28 , C07D277/34 , C07D277/64 , C07D295/20 , C07D307/52 , C07D307/56 , C07D307/58 , C07D307/81 , C07D307/83 , C07D317/58 , C07D319/18 , C07D333/16 , C07D333/20 , C07D333/28 , C07D333/32 , C07D333/56 , C07D333/58 , C07D333/64 , C07D405/04 , C07D409/04 , C07C259/04 , C07D213/24
Abstract: Certain carbocyclic aryl- and heterocyclic aryl- substituted cyclopropyl N-hydroxyureas, N-hydroxy-carboxamides, and N-acyl-N-hydroxyamines inhibit 5- and/or 12-lipoxygenase and are useful in the treatment of inflammatory disease states.
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公开(公告)号：PT96379A
公开(公告)日：1991-10-15
申请号：PT9637990
申请日：1990-12-27
Applicant: ABBOTT LAB
Inventor： BROOKS DEE W , RODRIQUES KAREN E , HORROM BRUCE W , MAZDIYASNI HORMOZ
IPC: A61K31/17 , A61K31/335 , A61K31/357 , A61K31/16 , A61K31/38 , A61K31/381 , A61K31/40 , A61K31/403 , A61K31/404 , A61K31/425 , A61K31/426 , A61K31/44 , A61K31/4402 , A61K31/4406 , A61K31/4409 , A61K31/4412 , A61K31/4418 , A61K31/443 , A61K31/445 , A61K31/47 , A61K31/495 , A61K31/535 , A61K31/5375 , A61K31/54 , A61P29/00 , A61P43/00 , C07C239/08 , C07C259/06 , C07C259/08 , C07C275/64 , C07D207/32 , C07D207/335 , C07D209/14 , C07D213/30 , C07D213/40 , C07D213/42 , C07D213/61 , C07D213/64 , C07D213/643 , C07D213/65 , C07D213/68 , C07D215/12 , C07D239/26 , C07D277/28 , C07D277/34 , C07D277/64 , C07D295/20 , C07D307/52 , C07D307/56 , C07D307/58 , C07D307/81 , C07D307/83 , C07D317/58 , C07D319/18 , C07D333/16 , C07D333/20 , C07D333/28 , C07D333/32 , C07D333/56 , C07D333/58 , C07D333/64 , C07D405/04 , C07D409/04 , C07C , C07D , A61K
Abstract: Certain carbocyclic aryl- and heterocyclic aryl- substituted cyclopropyl N-hydroxyureas, N-hydroxy-carboxamides, and N-acyl-N-hydroxyamines inhibit 5- and/or 12-lipoxygenase and are useful in the treatment of inflammatory disease states.
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公开(公告)号：CA2046872A1
公开(公告)日：1990-08-02
申请号：CA2046872
申请日：1990-01-25
Applicant: ABBOTT LAB
Inventor： BROOKS DEE W , RODRIQUES KAREN E , SUMMERS JAMES B
IPC: A61K31/17 , A61K31/215 , A61K31/34 , A61K31/341 , A61K31/343 , A61K31/38 , A61K31/381 , A61K31/40 , A61K31/403 , A61K31/404 , A61P37/06 , A61P43/00 , C07C275/64 , C07D207/09 , C07D209/14 , C07D213/30 , C07D213/68 , C07D307/42 , C07D307/52 , C07D307/81 , C07D333/16 , C07D333/20 , C07D333/32 , C07D333/56 , C07D333/58 , C07D333/64 , C07D405/04 , C07D405/06 , C07D409/04 , C07D409/06 , C07D307/54 , A61K31/33 , C07D207/337 , C07D209/18 , C07D409/02
Abstract: 2046872 9008545 PCTABS00001 Certain N-aryl-, N-heteroaryl-, N-arylalkyl-, N-heteroarylalkyl-, N-arylcyclopropyl- and N-heteroaryl-cyclopropyl-N'-hydroxyurea compounds are inhibitors of lipoxygenase enzyme activity and are thus useful agents in treating disease states such as asthma, arthritis, allergy, psoriasis, inflammatory bowel disease, gout, adult respiratory distress syndrome, endotoxin shock, and other inflammatory conditions in which the products of the arachidonic acid cascade are implicated.
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公开(公告)号：ES2083595T3
公开(公告)日：1996-04-16
申请号：ES91917405
申请日：1991-08-07
Applicant: ABBOTT LAB
Inventor： BROOKS DEE W , CARTER GEORGE W , DELLARIA JOSEPH F , MAKI ROBERT G , RODRIQUES KAREN E
IPC: A61K31/40 , A61K31/403 , A61K31/404 , A61K31/41 , A61K31/415 , A61K31/425 , A61K31/44 , A61K31/4427 , A61K31/443 , A61K31/4433 , A61K31/445 , A61K31/47 , A61K31/495 , A61K31/505 , A61P29/00 , A61P37/08 , A61P43/00 , C07D209/22 , C07D209/30 , C07D401/06 , C07D401/12 , C07D405/12 , C07D409/06 , C07D409/12 , C07D417/12 , C07D209/20 , C07D209/42 , C07D405/06 , C07D413/06 , C07D403/06
Abstract: PCT No. PCT/US91/05621 Sec. 371 Date Feb. 16, 1993 Sec. 102(e) Date Feb. 16, 1993 PCT Filed Aug. 7, 1991 PCT Pub. No. WO92/03132 PCT Pub. Date Mar. 5, 1992.Substituted indolyl compounds of the formulanase enzymes and are useful as agents for the treatment of allergies and inflammatory disease states.
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