公开(公告)号：AT131809T

公开(公告)日：1996-01-15

申请号：AT90119985

申请日：1990-10-18

Applicant: ABBOTT LAB

Inventor： CHU DANIEL T ,  PLATTNER JACOB J ,  KLEIN LARRY L ,  SHEN LINUS L

IPC: A61K31/47 ,  A61K31/495 ,  A61K31/535 ,  A61K31/54 ,  A61K31/55 ,  A61P35/00 ,  C07C333/06 ,  C07D513/04 ,  C07D513/14 ,  C07D519/00 ,  A61K31/435 ,  C07D275/00 ,  C07D221/00

Abstract: Isothiazolo-quinoline derivatives of the formula I which may exist as tautomers (formula II) are described which are cytotoxic for various tumor cell lines and are useful in the treatment of neoplastic diseases. wherein R is selected from (a) lower alkyl, (b) haloalkyl, (c) lowercycloalkyl, (d) alkylamino, (e) an aromatic heterocyclic group and (f) a phenyl group; W, X and Z are independently selected from hydrogen, halogen and lower alkyl; and Y is selected from a (a) phenyl group, (b) -NR2R3, (c) a bicyclic N-containing heterocyclic group, and (d) -OR10, wherein R10 is hydrogen, lower alkyl or a phenyl group; or any two of W, X, Y and Z taken together form a fused, substituted or unsubstituted, aromatic group or heterocyclic group.

公开(公告)号：PT95646A

公开(公告)日：1991-09-13

申请号：PT9564690

申请日：1990-10-22

Applicant: ABBOTT LAB

Inventor： CHU DANIEL T ,  PLATTNER JACOB J ,  KLEIN LARRY L ,  SHEN LINUS L

IPC: A61K31/47 ,  A61K31/495 ,  A61K31/535 ,  A61K31/54 ,  A61K31/55 ,  A61P35/00 ,  C07C333/06 ,  C07D513/04 ,  C07D513/14 ,  C07D519/00 ,  C07D ,  A61K31/33

Abstract: Isothiazolo-quinoline derivatives of the formula I which may exist as tautomers (formula II) are described which are cytotoxic for various tumor cell lines and are useful in the treatment of neoplastic diseases. wherein R is selected from (a) lower alkyl, (b) haloalkyl, (c) lowercycloalkyl, (d) alkylamino, (e) an aromatic heterocyclic group and (f) a phenyl group; W, X and Z are independently selected from hydrogen, halogen and lower alkyl; and Y is selected from a (a) phenyl group, (b) -NR2R3, (c) a bicyclic N-containing heterocyclic group, and (d) -OR10, wherein R10 is hydrogen, lower alkyl or a phenyl group; or any two of W, X, Y and Z taken together form a fused, substituted or unsubstituted, aromatic group or heterocyclic group.

公开(公告)号：IE71688B1

公开(公告)日：1997-02-26

申请号：IE363390

申请日：1990-10-10

Applicant: ABBOTT LAB

Inventor： CHU DANIEL T ,  KLEIN LARRY L ,  PLATTNER JACOB J ,  SHEN LINUS L

IPC: A61K31/47 ,  A61K31/495 ,  A61K31/535 ,  A61K31/54 ,  A61K31/55 ,  A61P35/00 ,  C07C333/06 ,  C07D513/04 ,  C07D513/14 ,  C07D519/00

Abstract: Isothiazolo-quinoline derivatives of the formula I which may exist as tautomers (formula II) are described which are cytotoxic for various tumor cell lines and are useful in the treatment of neoplastic diseases. wherein R is selected from (a) lower alkyl, (b) haloalkyl, (c) lowercycloalkyl, (d) alkylamino, (e) an aromatic heterocyclic group and (f) a phenyl group; W, X and Z are independently selected from hydrogen, halogen and lower alkyl; and Y is selected from a (a) phenyl group, (b) -NR2R3, (c) a bicyclic N-containing heterocyclic group, and (d) -OR10, wherein R10 is hydrogen, lower alkyl or a phenyl group; or any two of W, X, Y and Z taken together form a fused, substituted or unsubstituted, aromatic group or heterocyclic group.

公开(公告)号：GR3018961T3

公开(公告)日：1996-05-31

申请号：GR960400362

申请日：1996-02-14

Applicant: ABBOTT LAB

Inventor： CHU DANIEL T ,  PLATTNER JACOB J ,  KLEIN LARRY L ,  SHEN LINUS L

IPC: A61K31/47 ,  A61K31/495 ,  A61K31/535 ,  A61K31/54 ,  A61K31/55 ,  A61P35/00 ,  C07C333/06 ,  C07D513/04 ,  C07D513/14 ,  C07D519/00 ,  A61K31/435

Abstract: Isothiazolo-quinoline derivatives of the formula I which may exist as tautomers (formula II) are described which are cytotoxic for various tumor cell lines and are useful in the treatment of neoplastic diseases. wherein R is selected from (a) lower alkyl, (b) haloalkyl, (c) lowercycloalkyl, (d) alkylamino, (e) an aromatic heterocyclic group and (f) a phenyl group; W, X and Z are independently selected from hydrogen, halogen and lower alkyl; and Y is selected from a (a) phenyl group, (b) -NR2R3, (c) a bicyclic N-containing heterocyclic group, and (d) -OR10, wherein R10 is hydrogen, lower alkyl or a phenyl group; or any two of W, X, Y and Z taken together form a fused, substituted or unsubstituted, aromatic group or heterocyclic group.

公开(公告)号：DK0424802T3

公开(公告)日：1996-04-22

申请号：DK90119985

申请日：1990-10-18

Applicant: ABBOTT LAB

Inventor： CHU DANIEL T ,  PLATTNER JACOB J ,  KLEIN LARRY L ,  SHEN LINUS L

IPC: A61K31/47 ,  A61K31/495 ,  A61K31/535 ,  A61K31/54 ,  A61K31/55 ,  A61P35/00 ,  C07C333/06 ,  C07D513/04 ,  C07D513/14 ,  C07D519/00 ,  A61K31/435

Abstract: Isothiazolo-quinoline derivatives of the formula I which may exist as tautomers (formula II) are described which are cytotoxic for various tumor cell lines and are useful in the treatment of neoplastic diseases. wherein R is selected from (a) lower alkyl, (b) haloalkyl, (c) lowercycloalkyl, (d) alkylamino, (e) an aromatic heterocyclic group and (f) a phenyl group; W, X and Z are independently selected from hydrogen, halogen and lower alkyl; and Y is selected from a (a) phenyl group, (b) -NR2R3, (c) a bicyclic N-containing heterocyclic group, and (d) -OR10, wherein R10 is hydrogen, lower alkyl or a phenyl group; or any two of W, X, Y and Z taken together form a fused, substituted or unsubstituted, aromatic group or heterocyclic group.

公开(公告)号：IE903633A1

公开(公告)日：1991-04-24

申请号：IE363390

申请日：1990-10-10

Applicant: ABBOTT LAB

Inventor： CHU DANIEL T ,  KLEIN LARRY L ,  PLATTNER JACOB J ,  SHEN LINUS L

IPC: A61K31/47 ,  A61K31/495 ,  A61K31/535 ,  A61K31/54 ,  A61K31/55 ,  A61P35/00 ,  C07C333/06 ,  C07D513/04 ,  C07D513/14 ,  C07D519/00

Abstract: Isothiazolo-quinoline derivatives of the formula I which may exist as tautomers (formula II) are described which are cytotoxic for various tumor cell lines and are useful in the treatment of neoplastic diseases. wherein R is selected from (a) lower alkyl, (b) haloalkyl, (c) lowercycloalkyl, (d) alkylamino, (e) an aromatic heterocyclic group and (f) a phenyl group; W, X and Z are independently selected from hydrogen, halogen and lower alkyl; and Y is selected from a (a) phenyl group, (b) -NR2R3, (c) a bicyclic N-containing heterocyclic group, and (d) -OR10, wherein R10 is hydrogen, lower alkyl or a phenyl group; or any two of W, X, Y and Z taken together form a fused, substituted or unsubstituted, aromatic group or heterocyclic group.

公开(公告)号：CA2028246A1

公开(公告)日：1991-04-24

申请号：CA2028246

申请日：1990-10-22

Applicant: ABBOTT LAB

Inventor： CHU DANIEL T ,  KLEIN LARRY L ,  PLATTNER JACOB J ,  SHEN LINUS L

IPC: A61K31/47 ,  A61K31/495 ,  A61K31/535 ,  A61K31/54 ,  A61K31/55 ,  A61P35/00 ,  C07C333/06 ,  C07D513/04 ,  C07D513/14 ,  C07D519/00 ,  C07C333/04 ,  A61K31/395

Abstract: Isothiazolo-quinoline derivatives are described which are cytotoxic for various tumor cell lines and are useful in the treatment of neoplastic diseases.

公开(公告)号：DE69024322T2

公开(公告)日：1996-10-31

申请号：DE69024322

申请日：1990-10-18

Applicant: ABBOTT LAB

Inventor： CHU DANIEL T ,  PLATTNER JACOB J ,  KLEIN LARRY L ,  SHEN LINUS L

IPC: A61K31/47 ,  A61K31/495 ,  A61K31/535 ,  A61K31/54 ,  A61K31/55 ,  A61P35/00 ,  C07C333/06 ,  C07D513/04 ,  C07D513/14 ,  C07D519/00 ,  A61K31/435

Abstract: Isothiazolo-quinoline derivatives of the formula I which may exist as tautomers (formula II) are described which are cytotoxic for various tumor cell lines and are useful in the treatment of neoplastic diseases. wherein R is selected from (a) lower alkyl, (b) haloalkyl, (c) lowercycloalkyl, (d) alkylamino, (e) an aromatic heterocyclic group and (f) a phenyl group; W, X and Z are independently selected from hydrogen, halogen and lower alkyl; and Y is selected from a (a) phenyl group, (b) -NR2R3, (c) a bicyclic N-containing heterocyclic group, and (d) -OR10, wherein R10 is hydrogen, lower alkyl or a phenyl group; or any two of W, X, Y and Z taken together form a fused, substituted or unsubstituted, aromatic group or heterocyclic group.

公开(公告)号：ES2083990T3

公开(公告)日：1996-05-01

申请号：ES90119985

申请日：1990-10-18

Applicant: ABBOTT LAB

Inventor： CHU DANIEL T ,  PLATTNER JACOB J ,  KLEIN LARRY L ,  SHEN LINUS L

IPC: A61K31/47 ,  A61K31/495 ,  A61K31/535 ,  A61K31/54 ,  A61K31/55 ,  A61P35/00 ,  C07C333/06 ,  C07D513/04 ,  C07D513/14 ,  C07D519/00 ,  A61K31/435

Abstract: Isothiazolo-quinoline derivatives of the formula I which may exist as tautomers (formula II) are described which are cytotoxic for various tumor cell lines and are useful in the treatment of neoplastic diseases. wherein R is selected from (a) lower alkyl, (b) haloalkyl, (c) lowercycloalkyl, (d) alkylamino, (e) an aromatic heterocyclic group and (f) a phenyl group; W, X and Z are independently selected from hydrogen, halogen and lower alkyl; and Y is selected from a (a) phenyl group, (b) -NR2R3, (c) a bicyclic N-containing heterocyclic group, and (d) -OR10, wherein R10 is hydrogen, lower alkyl or a phenyl group; or any two of W, X, Y and Z taken together form a fused, substituted or unsubstituted, aromatic group or heterocyclic group.

公开(公告)号：DE69024322D1

公开(公告)日：1996-02-01

申请号：DE69024322

申请日：1990-10-18

Applicant: ABBOTT LAB

Inventor： CHU DANIEL T ,  PLATTNER JACOB J ,  KLEIN LARRY L ,  SHEN LINUS L

IPC: A61K31/47 ,  A61K31/495 ,  A61K31/535 ,  A61K31/54 ,  A61K31/55 ,  A61P35/00 ,  C07C333/06 ,  C07D513/04 ,  C07D513/14 ,  C07D519/00 ,  A61K31/435

Abstract: Isothiazolo-quinoline derivatives of the formula I which may exist as tautomers (formula II) are described which are cytotoxic for various tumor cell lines and are useful in the treatment of neoplastic diseases. wherein R is selected from (a) lower alkyl, (b) haloalkyl, (c) lowercycloalkyl, (d) alkylamino, (e) an aromatic heterocyclic group and (f) a phenyl group; W, X and Z are independently selected from hydrogen, halogen and lower alkyl; and Y is selected from a (a) phenyl group, (b) -NR2R3, (c) a bicyclic N-containing heterocyclic group, and (d) -OR10, wherein R10 is hydrogen, lower alkyl or a phenyl group; or any two of W, X, Y and Z taken together form a fused, substituted or unsubstituted, aromatic group or heterocyclic group.