公开(公告)号：PT734386E

公开(公告)日：2002-07-31

申请号：PT95904287

申请日：1994-12-08

Applicant: ABBOTT LAB

Inventor： CARRERA GEORGE M JR ,  XU LIANHONG ,  SUMMERS JAMES B JR ,  DAVIDSEN STEVEN K ,  CURTIN MICHAEL L ,  HEYMAN ROBIN H ,  SHEPPARD GEROGE S ,  GARLAND ROBERT B

IPC: A61K31/41 ,  A61K31/425 ,  A61K31/435 ,  A61K31/44 ,  A61K31/4427 ,  A61K31/443 ,  A61K31/4433 ,  A61K31/505 ,  A61P7/02 ,  A61P11/00 ,  C07D487/04 ,  A61P11/16 ,  A61P17/00 ,  A61P29/00 ,  A61P37/08 ,  C07D401/12 ,  C07D403/10 ,  C07D403/12 ,  C07D405/14 ,  C07D409/14 ,  C07D413/14 ,  C07D417/14 ,  C07D471/04 ,  A61K31/50

Abstract: The present invention relates to compounds of formula and the pharmaceutically acceptable salts thereof which are potent antagonists of PAF and are useful in the treatment of PAF-related disorders including asthma, shock, respiratory distress syndrome, acute inflammation, transplanted organ rejection, gastrointestinal ulceration, allergic skin diseases, delayed cellular immunity, parturition, fetal lung maturation, and cellular differentiation.