公开(公告)号：EP2185201A4

公开(公告)日：2011-11-30

申请号：EP08795162

申请日：2008-08-08

Applicant: ABBOTT LAB

Inventor： FRAUNHOFER WOLFGANG ,  BORHANI DAVID W ,  WINTER GERHARD ,  GOTTSCHALK STEFAN

IPC: C12N15/10 ,  A61K39/395 ,  C07K16/24

CPC classification number: C07K16/241 ,  A61K2039/505 ,  C07K1/306 ,  C07K2299/00 ,  C07K2317/14 ,  C07K2317/54 ,  C07K2317/76 ,  C30B29/58

Abstract: The present invention relates to a batch crystallization method for crystallizing anti-human TNFalpha (hTNFalpha) antibody and antibody fragments which allows the production of said antibody on an industrial scale; a method of controlling the size of antibody crystals, for example, crystals of anti-hTNFalpha antibody fragments, compositions containing said crystals as well as methods of use of said crystals and compositions.

Abstract translation: 本发明涉及用于结晶抗人TNFα（hTNFα）抗体的批量结晶方法和允许以工业规模生产所述抗体的抗体片段; 控制抗体晶体大小的方法，例如抗hTNFα抗体片段的晶体，含有所述晶体的组合物以及所述晶体和组合物的使用方法。

公开(公告)号：EP2142565A4

公开(公告)日：2010-03-31

申请号：EP08742311

申请日：2008-03-27

Applicant: ABBOTT LAB

Inventor： BORHANI DAVID W ,  FRAUNHOFER WOLFGANG ,  KRAUSE HANS-JUERGEN ,  KOENIGSDORFER ANETTE ,  WINTER GERHARD ,  GOTTSCHALK STEFAN

IPC: C07K16/00 ,  C07K16/24 ,  C12P21/08

CPC classification number: C07K16/244 ,  A61K39/39591 ,  C07K2299/00 ,  C30B7/00

Abstract: The invention relates to batch crystallization methods for crystallizing an anti-hIL-12 antibody that allows the production of the antibody on an industrial scale, antibody crystals obtained according to the methods, compositions containing the crystals, and methods of using the crystals and the compositions.

Abstract translation: 本发明涉及用于结晶能够以工业规模生产抗体的抗-hIL-12抗体的分批结晶方法，根据该方法获得的抗体晶体，含有晶体的组合物，以及使用晶体和组合物的方法 。

公开(公告)号：AU2013203076A1

公开(公告)日：2013-05-02

申请号：AU2013203076

申请日：2013-04-09

Applicant: ABBOTT LAB

Inventor： KOENIGSDORFER ANETTE ,  BORHANI DAVID W ,  FRAUNHOFER WOLFGANG ,  KRAUSE HANS-JUERGEN ,  GOTTSCHALK STEFAN ,  WINTER GERHARD

IPC: C07K16/00 ,  C12P21/08

Abstract: Abstract The invention relates to batch crystallization methods for crystalizing an anti-hlL-12 antibody that allows the production of the antibody on an industrial scale, antibody crystals obtained according to the methods, compositions containing the crystals, and methods of using the crystals and the compositions.

公开(公告)号：MX2010001488A

公开(公告)日：2010-03-01

申请号：MX2010001488

申请日：2008-08-08

Applicant: ABBOTT LAB

Inventor： BORHANI DAVID W ,  WINTER GERHARD ,  FRAUNHOFER WOLFGANG ,  GOTTSCHALK STEFAN

IPC: A61K39/395

Abstract: La presente invención se refiere a un método de cristalización por lotes, para cristalizar un anticuerpo y fragmentos de anticuerpo TNFalfa anti-humano (hTNFalfa), el cual permite la producción del anticuerpo en una escala industrial; a un método para controlar el tamaño de los cristales del anticuerpo. Por ejemplo, cristales de fragmentos de anticuerpo anti-hTNFalfa, a composiciones que contienen dichos cristales, así como a métodos de uso de dichos cristales y composiciones.

公开(公告)号：CA2681752A1

公开(公告)日：2008-10-09

申请号：CA2681752

申请日：2008-03-27

Applicant: ABBOTT LAB

Inventor： GOTTSCHALK STEFAN ,  KRAUSE HANS-JUERGEN ,  BORHANI DAVID W ,  FRAUNHOFER WOLFGANG ,  KOENIGSDORFER ANETTE ,  WINTER GERHARD

IPC: C07K16/24 ,  A61K39/395 ,  A61P37/02 ,  C30B7/00 ,  C30B29/58

Abstract: The invention relates to batch crystallization methods for crystallizing an anti-hIL-12 antibody that allows the production of the antibody on an ind ustrial scale, antibody crystals obtained according to the methods, composit ions containing the crystals, and methods of using the crystals and the comp ositions.

公开(公告)号：AU2008233173A1

公开(公告)日：2008-10-09

申请号：AU2008233173

申请日：2008-03-27

Applicant: ABBOTT LAB

Inventor： BORHANI DAVID W ,  KOENIGSDORFER ANETTE ,  FRAUNHOFER WOLFGANG ,  WINTER GERHARD ,  KRAUSE HANS-JUERGEN ,  GOTTSCHALK STEFAN

IPC: C07K16/00 ,  C12P21/08

Abstract: The invention relates to batch crystallization methods for crystallizing an anti-hIL-12 antibody that allows the production of the antibody on an industrial scale, antibody crystals obtained according to the methods, compositions containing the crystals, and methods of using the crystals and the compositions.

公开(公告)号：BRPI0809209A2

公开(公告)日：2014-09-02

申请号：BRPI0809209

申请日：2008-03-27

Applicant: ABBOTT LAB

Inventor： BORHANI DAVID W ,  FRAUNHOFER WOLFGANG ,  KRAUSE HANS-JUERGEN ,  KOENIGSDORFER ANETTE ,  WINTER GERHARD ,  GOTTSCHALK STEFAN

IPC: C07K16/00 ,  C12P21/08

Abstract: The invention relates to batch crystallization methods for crystallizing an anti-hIL-12 antibody that allows the production of the antibody on an industrial scale, antibody crystals obtained according to the methods, compositions containing the crystals, and methods of using the crystals and the compositions.

公开(公告)号：ZA200906432B

公开(公告)日：2015-08-26

申请号：ZA200906432

申请日：2009-09-15

Applicant: ABBOTT LAB

Inventor： KOENINGSDORFER ANETTE ,  GOTTSCHALK STEFAN ,  KRAUSE HANS-JUERGEN ,  FRAUNHOFER WOLFGANG ,  BORHANI DAVID W ,  WINTER GERHARD

Abstract: The invention relates to batch crystallization methods for crystallizing an anti-hIL-12 antibody that allows the production of the antibody on an industrial scale, antibody crystals obtained according to the methods, compositions containing the crystals, and methods of using the crystals and the compositions.

公开(公告)号：MX2009010361A

公开(公告)日：2009-10-16

申请号：MX2009010361

申请日：2008-03-27

Applicant: ABBOTT LAB

Inventor： BORHANI DAVID W ,  WINTER GERHARD ,  FRAUNHOFER WOLFGANG ,  KRAUSE HANS-JUERGEN ,  KOENIGSDORFER ANETTE ,  GOTTSCHALK STEFAN

IPC: C12P21/08 ,  C07K16/00

Abstract: La invención se refiere a métodos de cristalización por lote para cristalizar un anticuerpo anti-hlL-12, que permiten la producción del anticuerpo a una escala industrial, cristales de anticuerpo obtenidos de acuerdo con los métodos, composiciones que contienen los cristales, y métodos para usar los cristales y las composiciones.

公开(公告)号：NZ580379A

公开(公告)日：2012-10-26

申请号：NZ58037908

申请日：2008-03-27

Applicant: ABBOTT LAB

Inventor： BORHANI DAVID W ,  FRAUNHOFER WOLFGANG ,  KRAUSE HANS-JUERGEN ,  KOENIGSDORFER ANETTE ,  WINTER GERHARD ,  GOTTSCHALK STEFAN

IPC: C12P21/08 ,  C07K16/00

Abstract: Disclosed is a batch crystallization method for crystallizing an anti-human IL-12 antibody, the method comprising the steps of: (a) providing an aqueous crystallization mixture having an aqueous solution of the antibody in admixture with at least one polyalkylene glycol having an average molecular weight in the range of about 400 to about 10,000 as a crystallization agent wherein the antibody concentration is in the range of about 0.5 to about 280 mg/ml; and (b) incubating the aqueous crystallization mixture at a pH of about pH 4 to about 6.5 and at a temperature of about 4o C to about 37o C until crystals of the antibody having a length of about 2-500 ìm are formed. Also disclosed is a crystal of an anti-human IL-12 antibody obtained by a batch crystallization method. Further disclosed is the use of the anti-human IL-12 antibody crystal in the manufacture of a medicament for the treatment of an IL-12 related disorder