公开(公告)号：WO2004000869A1

公开(公告)日：2003-12-31

申请号：PCT/US2003/019157

申请日：2003-06-17

Applicant: ABBOTT LABORATORIES

Inventor： VON GELDERN, Thomas, W. ,  LINK, James, T. ,  TU, Noah ,  KYM, Philip, R. ,  LAI, Chunqiu ,  RICHARDS, Steven, J. ,  JACOBSON, Peer, B. ,  BISHOP, Richard, D. ,  GATES, Bradley, D.

IPC: C07J41/00

CPC classification number: C07J41/0083 ,  C07J41/0061

Abstract: This invention relates to novel compounds that are liver selective glucocorticoid receptor antagonists, to methods of preparing such compounds, and to methods for using such compounds in the regulation of metabolism, especially lowering serum glucose levels, insulin levels, or lipid levels, and/or decreasing body weight.

Abstract translation: 本发明涉及作为肝脏选择性糖皮质激素受体拮抗剂的新型化合物，制备这些化合物的方法，以及使用这些化合物来调节代谢的方法，特别是降低血清葡萄糖水平，胰岛素水平或脂质水平，和/或 减轻体重。

公开(公告)号：WO2005019191A2

公开(公告)日：2005-03-03

申请号：PCT/US2004/027000

申请日：2004-08-19

Applicant: ABBOTT LABORATORIES ,  HUTCHINSON, Douglas, K. ,  BELLETTINI, John, R. ,  BETEBENNER, David, A. ,  BISHOP, Richard, D. ,  BORCHARDT, Thomas, B. ,  BOSSE, Todd, D. ,  CINK, Russell, D. ,  FLENTGE, Charles, A. ,  GATES, Bradley, D. ,  GREEN, Brian, E. ,  HINMAN, Mira, M. ,  HUANG, Peggy, P. ,  KLEIN, Larry, L. ,  KRUEGER, Allan, C. ,  LARSON, Daniel, P. ,  LEANNA, M., Robert ,  LIU, Dachun ,  MADIGAN, Darold, L. ,  MCDANIEL, Keith, F. ,  RANDOLPH, John, T. ,  ROCKWAY, Todd, W. ,  ROSENBERG, Teresa, A. ,  STEWART, Kent, D. ,  STOLL, Vincent, S. ,  WAGNER, Rolf ,  YEUNG, Ming, C.

Inventor： HUTCHINSON, Douglas, K. ,  BELLETTINI, John, R. ,  BETEBENNER, David, A. ,  BISHOP, Richard, D. ,  BORCHARDT, Thomas, B. ,  BOSSE, Todd, D. ,  CINK, Russell, D. ,  FLENTGE, Charles, A. ,  GATES, Bradley, D. ,  GREEN, Brian, E. ,  HINMAN, Mira, M. ,  HUANG, Peggy, P. ,  KLEIN, Larry, L. ,  KRUEGER, Allan, C. ,  LARSON, Daniel, P. ,  LEANNA, M., Robert ,  LIU, Dachun ,  MADIGAN, Darold, L. ,  MCDANIEL, Keith, F. ,  RANDOLPH, John, T. ,  ROCKWAY, Todd, W. ,  ROSENBERG, Teresa, A. ,  STEWART, Kent, D. ,  STOLL, Vincent, S. ,  WAGNER, Rolf ,  YEUNG, Ming, C.

IPC: C07D285/00

CPC classification number: C07D417/12 ,  C07D285/24 ,  C07D285/30 ,  C07D513/04

Abstract: Compounds having the formula (I) are hepatitis C (HCV) polymerase inhibitors. Also disclosed are a composition and method for inhibiting hepatitis C (HCV) polymerase, processes for making the compounds, and synthetic intermediates employed in the processes.

Abstract translation: 具有式（I）的化合物是丙型肝炎（HCV）聚合酶抑制剂。 还公开了用于抑制丙型肝炎（HCV）聚合酶的组合物和方法，用于制备化合物的方法和在该方法中使用的合成中间体。