公开(公告)号：WO1998012172A1

公开(公告)日：1998-03-26

申请号：PCT/US1997016769

申请日：1997-09-22

Applicant: ABBOTT LABORATORIES

Inventor： ABBOTT LABORATORIES ,  WANG, Xiu, C. ,  BHATIA, Ashok, V. ,  CHAMBERLIN, Steve, A. ,  LIU, Luping

IPC: C07C217/32

CPC classification number: C07C41/16 ,  C07C213/06 ,  C07C2601/02 ,  C07D303/23 ,  C07C217/34 ,  C07C43/23

Abstract: The present invention relates to a process for the selective alkylation of intermediates of betaxolol.

Abstract translation: 本发明涉及一种选择性烷基化倍他洛尔中间体的方法。

公开(公告)号：WO2004037769A2

公开(公告)日：2004-05-06

申请号：PCT/US2003/033527

申请日：2003-10-22

Applicant: ABBOTT LABORATORIES

Inventor： BENNANI, Youssef, L. ,  CHAMBERLIN, Steve, A. ,  CHEMBURKAR, Sanjay, R. ,  CHEN, Jinhua ,  DART, Michael, J. ,  GUPTA, Ashok, K. ,  WANG, Lei

IPC: C07C233/00

CPC classification number: A61K31/16 ,  A61K31/33 ,  A61K31/397 ,  A61K31/54 ,  A61K31/55 ,  C07C233/08 ,  C07C233/58 ,  C07C233/60 ,  C07C233/63 ,  C07C237/22 ,  C07C2601/14 ,  C07D233/24

Abstract: The present invention relates to the use of compounds of formula (I)for the treatment of a variety of disorders including, but not limited to, epilepsy, bipolar disorder, psychiatric disorders, migraine, pain, neuroprotection, and movement disorders.

Abstract translation: 本发明涉及式（I）化合物用于治疗各种疾病的用途，所述疾病包括但不限于癫痫，双相情感障碍，精神障碍，偏头痛，疼痛，神经保护和运动障碍。

公开(公告)号：WO1998013334A1

公开(公告)日：1998-04-02

申请号：PCT/US1997017446

申请日：1997-09-29

Applicant: ABBOTT LABORATORIES

Inventor： ABBOTT LABORATORIES ,  WANG, Xiu, C. ,  CHAMBERLIN, Steve, A. ,  BHATIA, Ashok, V. ,  ROBINSON, Gregg, E. ,  HUFNAGEL, John

IPC: C07C231/08

CPC classification number: C07C213/02

Abstract: Provided is a novel process for the preparation of iohexol having improved yields and purity, reduced number of isolated intermediates, and significantly reduced volume of ion-exchange resins required to desalinate the final product.

Abstract translation: 提供了一种制备具有提高的产率和纯度，减少分离的中间体数量和显着减少脱盐最终产物所需的离子交换树脂的体积的新型方法。

公开(公告)号：EP0931055A1

公开(公告)日：1999-07-28

申请号：EP97943421.0

申请日：1997-09-22

Applicant: Abbott Laboratories

Inventor： WANG, Xiu, C. ,  BHATIA, Ashok, V. ,  CHAMBERLIN, Steve, A. ,  LIU, Luping

IPC: C07C213 ,  C07C41 ,  C07C43 ,  C07C217

CPC classification number: C07C41/16 ,  C07C213/06 ,  C07C2601/02 ,  C07D303/23 ,  C07C217/34 ,  C07C43/23

Abstract: The present invention relates to a process for the selective alkylation of intermediates of betaxolol.

公开(公告)号：EP1606244A2

公开(公告)日：2005-12-21

申请号：EP03779179.5

申请日：2003-10-22

Applicant: ABBOTT LABORATORIES

Inventor： BENNANI, Youssef, L. ,  CHAMBERLIN, Steve, A. ,  CHEMBURKAR, Sanjay, R. ,  CHEN, Jinhua ,  DART, Michael, J. ,  GUPTA, Ashok, K. ,  WANG, Lei

IPC: C07C233/63 ,  C07C233/60 ,  C07C233/58 ,  A61K31/16 ,  A61P25/08 ,  A61P25/06 ,  C07D233/24

CPC classification number: A61K31/16 ,  A61K31/33 ,  A61K31/397 ,  A61K31/54 ,  A61K31/55 ,  C07C233/08 ,  C07C233/58 ,  C07C233/60 ,  C07C233/63 ,  C07C237/22 ,  C07C2601/14 ,  C07D233/24

Abstract: The present invention relates to the use of compounds of formula (I)for the treatment of a variety of disorders including, bu t not limited to, epilepsy, bipolar disorder, psychiatric disorders, migraine, pain, neuroprotection, and movement disorders.

Abstract translation: 本发明涉及式（I）化合物用于治疗各种疾病的用途，包括但不限于癫痫，双相情感障碍，精神病学障碍，偏头痛，疼痛，神经保护和运动障碍。

公开(公告)号：EP0931055B1

公开(公告)日：2001-11-07

申请号：EP97943421.4

申请日：1997-09-22

Applicant: Abbott Laboratories

Inventor： WANG, Xiu, C. ,  BHATIA, Ashok, V. ,  CHAMBERLIN, Steve, A. ,  LIU, Luping

IPC: C07C217/32 ,  C07C43/178 ,  C07C41/16

CPC classification number: C07C41/16 ,  C07C213/06 ,  C07C2601/02 ,  C07D303/23 ,  C07C217/34 ,  C07C43/23

Abstract: The present invention relates to a process for the selective alkylation of intermediates of betaxolol.

Abstract translation: 本发明涉及一种用于倍他洛尔的中间体的选择性烷基化的方法。