公开(公告)号：WO1998012172A1

公开(公告)日：1998-03-26

申请号：PCT/US1997016769

申请日：1997-09-22

Applicant: ABBOTT LABORATORIES

Inventor： ABBOTT LABORATORIES ,  WANG, Xiu, C. ,  BHATIA, Ashok, V. ,  CHAMBERLIN, Steve, A. ,  LIU, Luping

IPC: C07C217/32

CPC classification number: C07C41/16 ,  C07C213/06 ,  C07C2601/02 ,  C07D303/23 ,  C07C217/34 ,  C07C43/23

Abstract: The present invention relates to a process for the selective alkylation of intermediates of betaxolol.

Abstract translation: 本发明涉及一种选择性烷基化倍他洛尔中间体的方法。

公开(公告)号：WO1997048690A1

公开(公告)日：1997-12-24

申请号：PCT/US1997010337

申请日：1997-06-18

Applicant: ABBOTT LABORATORIES

Inventor： ABBOTT LABORATORIES ,  WANG, Xiu, C. ,  LIU, Luping ,  BHATIA, Ashok, V.

IPC: C07D301/00

CPC classification number: C07D301/00 ,  C07C213/04 ,  C07D303/24

Abstract: The hydroxy group of an epoxy-alcohol is selectively alkylated, without affecting the epoxy group, by reaction with an alkylating agent in the presence of a solvent and a strong base. As an example, Betaxolol (4) can be prepared according to scheme (1).

Abstract translation: 通过在溶剂和强碱的存在下与烷基化剂反应，选择性地烷基化环氧醇的羟基而不影响环氧基。 作为例子，可以按照方案（1）制备倍他洛尔（4）。

公开(公告)号：EP0931055B1

公开(公告)日：2001-11-07

申请号：EP97943421.4

申请日：1997-09-22

Applicant: Abbott Laboratories

Inventor： WANG, Xiu, C. ,  BHATIA, Ashok, V. ,  CHAMBERLIN, Steve, A. ,  LIU, Luping

IPC: C07C217/32 ,  C07C43/178 ,  C07C41/16

CPC classification number: C07C41/16 ,  C07C213/06 ,  C07C2601/02 ,  C07D303/23 ,  C07C217/34 ,  C07C43/23

Abstract: The present invention relates to a process for the selective alkylation of intermediates of betaxolol.

Abstract translation: 本发明涉及一种用于倍他洛尔的中间体的选择性烷基化的方法。

公开(公告)号：EP0925290B1

公开(公告)日：2003-11-19

申请号：EP97930006.8

申请日：1997-06-18

Applicant: Abbott Laboratories

Inventor： WANG, Xiu, C. ,  LIU, Luping ,  BHATIA, Ashok, V.

IPC: C07D301/00 ,  C07D303/00 ,  C07D303/24 ,  C07C213/04

CPC classification number: C07D301/00 ,  C07C213/04 ,  C07D303/24

Abstract: The hydroxy group of an epoxy-alcohol is selectively alkylated, without affecting the epoxy group, by reaction with an alkylating agent in the presence of a solvent and a strong base. As an example, Betaxolol (4) can be prepared according to scheme (1).

公开(公告)号：EP0931055A1

公开(公告)日：1999-07-28

申请号：EP97943421.0

申请日：1997-09-22

Applicant: Abbott Laboratories

Inventor： WANG, Xiu, C. ,  BHATIA, Ashok, V. ,  CHAMBERLIN, Steve, A. ,  LIU, Luping

IPC: C07C213 ,  C07C41 ,  C07C43 ,  C07C217

CPC classification number: C07C41/16 ,  C07C213/06 ,  C07C2601/02 ,  C07D303/23 ,  C07C217/34 ,  C07C43/23

Abstract: The present invention relates to a process for the selective alkylation of intermediates of betaxolol.

公开(公告)号：EP0925290A1

公开(公告)日：1999-06-30

申请号：EP97930006.0

申请日：1997-06-18

Applicant: Abbott Laboratories

Inventor： WANG, Xiu, C. ,  LIU, Luping ,  BHATIA, Ashok, V.

IPC: C07C213 ,  C07D301 ,  C07D303

CPC classification number: C07D301/00 ,  C07C213/04 ,  C07D303/24

Abstract: The hydroxy group of an epoxy-alcohol is selectively alkylated, without affecting the epoxy group, by reaction with an alkylating agent in the presence of a solvent and a strong base. As an example, Betaxolol (4) can be prepared according to scheme (1).