公开(公告)号：WO2011068560A1

公开(公告)日：2011-06-09

申请号：PCT/US2010/036844

申请日：2010-06-01

Applicant: ABBOTT LABORATORIES ,  BRUNCKO, Milan ,  DAI, Yujia ,  DING, Hong ,  DOHERTY, George A. ,  ELMORE, Steven W. ,  HASVOLD, Lisa ,  HEXAMER, Laura ,  KUNZER, Aaron ,  MANTEI, Robert A. ,  McCLELLAN, William J. ,  PARK, Chang H. ,  PARK, Cheol-Min ,  PETROS, Andrew M. ,  SONG, Xiaohong ,  SOUERS, Andrew J. ,  SULLIVAN, Gerard M. ,  TAO, Zhi-Fu ,  WANG, Gary T. ,  WANG, Le ,  WANG, Xilu ,  WENDT, Michael D. ,  HANSEN, Todd M.

Inventor： BRUNCKO, Milan ,  DAI, Yujia ,  DING, Hong ,  DOHERTY, George A. ,  ELMORE, Steven W. ,  HASVOLD, Lisa ,  HEXAMER, Laura ,  KUNZER, Aaron ,  MANTEI, Robert A. ,  McCLELLAN, William J. ,  PARK, Chang H. ,  PARK, Cheol-Min ,  PETROS, Andrew M. ,  SONG, Xiaohong ,  SOUERS, Andrew J. ,  SULLIVAN, Gerard M. ,  TAO, Zhi-Fu ,  WANG, Gary T. ,  WANG, Le ,  WANG, Xilu ,  WENDT, Michael D. ,  HANSEN, Todd M.

IPC: C07D209/08 ,  C07D211/58 ,  C07D213/74 ,  C07D213/84 ,  C07D231/56 ,  C07D235/06 ,  C07D277/24 ,  C07D309/04 ,  C07D401/14 ,  C07D403/12 ,  C07D405/12 ,  C07D405/14 ,  C07D413/12 ,  C07D417/12 ,  C07D471/04

CPC classification number: C07D209/08 ,  A61K31/635 ,  C07D211/58 ,  C07D213/74 ,  C07D213/84 ,  C07D231/56 ,  C07D235/06 ,  C07D277/24 ,  C07D295/30 ,  C07D309/04 ,  C07D309/08 ,  C07D401/12 ,  C07D401/14 ,  C07D403/12 ,  C07D405/12 ,  C07D405/14 ,  C07D413/12 ,  C07D417/12 ,  C07D471/04

Abstract: Disclosed are compounds which inhibit the activity of anti-apoptotic Bcl-2 proteins, compositions containing the compounds and methods of treating diseases during which is expressed anti-apoptotic Bcl-2 protein.

公开(公告)号：WO2010065824A2

公开(公告)日：2010-06-10

申请号：PCT/US2009/066722

申请日：2009-12-04

Applicant: ABBOTT LABORATORIES ,  BRUNCKO, Milan ,  DAI, Yujia ,  DING, Hong ,  DOHERTY, George, A. ,  ELMORE, Steven, W. ,  HASVOLD, Lisa ,  HEXAMER, Laura ,  KUNZER, Aaron, R. ,  MANTEI, Robert, A. ,  MCCLELLAN, William, J. ,  PARK, Chang, H. ,  PARK, Cheol-Min ,  PETROS, Andrew, M. ,  SONG, Xiaohong ,  SOUERS, Andrew, J. ,  SULLIVAN, Gerard, M. ,  TAO, Zhi-Fu ,  WANG, Gary, T. ,  WANG, Le ,  WANG, Xilu ,  WENDT, Michael, D.

Inventor： BRUNCKO, Milan ,  DAI, Yujia ,  DING, Hong ,  DOHERTY, George, A. ,  ELMORE, Steven, W. ,  HASVOLD, Lisa ,  HEXAMER, Laura ,  KUNZER, Aaron, R. ,  MANTEI, Robert, A. ,  MCCLELLAN, William, J. ,  PARK, Chang, H. ,  PARK, Cheol-Min ,  PETROS, Andrew, M. ,  SONG, Xiaohong ,  SOUERS, Andrew, J. ,  SULLIVAN, Gerard, M. ,  TAO, Zhi-Fu ,  WANG, Gary, T. ,  WANG, Le ,  WANG, Xilu ,  WENDT, Michael, D.

IPC: A61P35/00 ,  A61K31/496 ,  C07D403/12

CPC classification number: C07D405/12 ,  C07D209/08 ,  C07D211/58 ,  C07D213/74 ,  C07D213/84 ,  C07D231/56 ,  C07D235/06 ,  C07D277/24 ,  C07D295/30 ,  C07D309/04 ,  C07D401/14 ,  C07D405/14 ,  C07D413/12 ,  C07D417/12 ,  C07D471/04

Abstract: Disclosed are compounds which inhibit the activity of anti-apoptotic Bcl-2 proteins, compositions containing the compounds and methods of treating diseases during which is expressed anti-apoptotic Bcl-2 protein.

Abstract translation: 公开了抑制抗凋亡Bcl-2蛋白活性的化合物，含有化合物的组合物和治疗疾病的方法，其中表达抗凋亡Bcl-2蛋白。

公开(公告)号：WO2007067781A2

公开(公告)日：2007-06-14

申请号：PCT/US2006/047078

申请日：2006-12-08

Applicant: ABBOTT LABORATORIES ,  MICHAELIDES, Michael, R. ,  MCCLELLAN, William, J. ,  FREY, Robin, R. ,  CURTIN, Michael, L. ,  STEINMAN, Douglas, H. ,  DAI, Yujia ,  HOLMS, James, H.

Inventor： MICHAELIDES, Michael, R. ,  MCCLELLAN, William, J. ,  FREY, Robin, R. ,  CURTIN, Michael, L. ,  STEINMAN, Douglas, H. ,  DAI, Yujia ,  HOLMS, James, H.

IPC: C07D487/04 ,  C07D495/04 ,  A61K31/519 ,  A61P35/00

CPC classification number: C07F9/6561 ,  C07D487/04 ,  C07D495/04

Abstract: Compounds that inhibit protein kinases, compositions containing the compounds and methods of treating diseases using the compounds are disclosed.

Abstract translation: 公开了抑制蛋白激酶的化合物，含有化合物的组合物和使用该化合物治疗疾病的方法。

公开(公告)号：WO2003080625A1

公开(公告)日：2003-10-02

申请号：PCT/US2003/008647

申请日：2003-03-20

Applicant: ABBOTT LABORATORIES

Inventor： MICHAELIDES, Michael, R. ,  DAI, Yujia ,  DAVIDSEN, Steven, K. ,  FREY, Robin, R. ,  GUO, Yan ,  JI, Zhiqin ,  CURTIN, Michael

IPC: C07D495/04

CPC classification number: C07D495/04 ,  C07D513/04

Abstract: Compounds having the formula are useful for inhibiting protein tyrosine kinases. The present invention also discloses methods of making the compounds, compositions containing the compounds, and methods of treatment using the compounds.

Abstract translation: 具有该式的化合物可用于抑制蛋白酪氨酸激酶。 本发明还公开了制备化合物的方法，含有该化合物的组合物和使用该化合物的处理方法。

公开(公告)号：WO2013097601A1

公开(公告)日：2013-07-04

申请号：PCT/CN2012/086357

申请日：2012-12-11

Applicant: ABBVIE INC. ,  ABBOTT LABORATORIES TRADING (SHANGHAI) COMPANY, LTD.

Inventor： WANG, Le ,  PRATT, John K. ,  MCDANIEL, Keith F. ,  DAI, Yujia ,  FIDANZE, Steven D. ,  HASVOLD, Lisa ,  HOLMS, James H. ,  KATI, Warren M. ,  LIU, Dachun ,  MANTEI, Robert A. ,  MCCLELLAN, William J ,  SHEPPARD, George S. ,  WADA, Carol K.

IPC: C07D471/04 ,  A61K31/407 ,  A61P35/00 ,  A61P31/18 ,  A61P13/12 ,  A61P3/10

CPC classification number: A61K31/541 ,  A61K31/437 ,  A61K31/5025 ,  A61K31/5377 ,  A61K45/06 ,  C07D471/04 ,  C07D487/04

Abstract: The present invention provides for compounds of formula (I) wherein A 1 , A 2 , A 3 , A 4 , X 1 , X 2 , Y 1 , L 1 , G 1 , R x , and R y have any of the values defined thereof in the specification, and pharmaceutically acceptable salts thereof, that are useful as agents in the treatment of diseases and conditions, including inflammatory diseases, cancer, and AIDS. Also provided are pharmaceutical compositions comprising one or more compounds of formula (I).

Abstract translation: 本发明提供式（I）化合物，其中A1，A2，A3，A4，X1，X2，Y1，L1，G1，Rx和Ry具有说明书中定义的任何值及其药学上可接受的盐 ，其作为治疗疾病和病症（包括炎性疾病，癌症和AIDS）的药剂是有用的。 还提供了包含一种或多种式（I）化合物的药物组合物。

公开(公告)号：WO2006050109A2

公开(公告)日：2006-05-11

申请号：PCT/US2005/038958

申请日：2005-10-28

Applicant: ABBOTT LABORATORIES ,  DAI, Yujia ,  HARTANDI, Kresna ,  MICHAELIDES, Michael, M.

Inventor： DAI, Yujia ,  HARTANDI, Kresna ,  MICHAELIDES, Michael, M.

CPC classification number: C07D471/04 ,  C07D487/04

Abstract: Compounds having the formula (I) are useful for inhibiting protein tyrosine kinases. The present invention also discloses methods of making the compounds, compositions containing the compounds, and methods of treatment using the compounds.

Abstract translation: 具有式（I）的化合物可用于抑制蛋白酪氨酸激酶。 本发明还公开了制备所述化合物的方法，含有所述化合物的组合物以及使用所述化合物的治疗方法。

公开(公告)号：WO2009012312A1

公开(公告)日：2009-01-22

申请号：PCT/US2008/070180

申请日：2008-07-16

Applicant: ABBOTT LABORATORIES ,  DAI, Yujia ,  ZHIQIN, Ji ,  MICHAELIDES, Michael R.

Inventor： DAI, Yujia ,  ZHIQIN, Ji ,  MICHAELIDES, Michael R.

IPC: C07D231/56 ,  C07D261/20 ,  C07D275/04 ,  A61K31/416 ,  A61K31/423 ,  A61K31/428 ,  A61P35/00

CPC classification number: C07D231/56 ,  C07D261/20 ,  C07D275/04

Abstract: Compounds that inhibit Aurora-kinases, compositions containing the compounds and methods of treating diseases using the compounds are disclosed.

Abstract translation: 公开了抑制极光激酶的化合物，含有化合物的组合物和使用该化合物治疗疾病的方法。

公开(公告)号：WO2004113304A1

公开(公告)日：2004-12-29

申请号：PCT/US2004/016166

申请日：2004-05-21

Applicant: ABBOTT LABORATORIES ,  DAI, Yujia ,  DAVIDSEN, Steven, K. ,  ERICSSON, Anna, M. ,  HARTANDI, Kresna ,  JI, Zhiqin ,  MICHAELIDES, Michael, R.

Inventor： DAI, Yujia ,  DAVIDSEN, Steven, K. ,  ERICSSON, Anna, M. ,  HARTANDI, Kresna ,  JI, Zhiqin ,  MICHAELIDES, Michael, R.

IPC: C07D231/56

CPC classification number: C07D231/56 ,  C07D261/20 ,  C07D275/04 ,  C07D401/04 ,  C07D401/12 ,  C07D403/04 ,  C07D403/12 ,  C07D405/12 ,  C07D409/04 ,  Y02P20/582

Abstract: Compounds having the formula (I) are useful for inhibiting protein tyrosine kinases. The present invention also discloses methods of making the compounds, compositions containing the compounds, and methods of treatment using the compounds.

Abstract translation: 具有式（I）的化合物可用于抑制蛋白酪氨酸激酶。 本发明还公开了制备化合物的方法，含有该化合物的组合物和使用该化合物的处理方法。

公开(公告)号：EP1487841A1

公开(公告)日：2004-12-22

申请号：EP03716742.6

申请日：2003-03-20

Applicant: Abbott Laboratories

Inventor： MICHAELIDES, Michael, R. ,  DAI, Yujia ,  DAVIDSEN, Steven, K. ,  FREY, Robin, R. ,  GUO, Yan ,  JI, Zhiqin ,  CURTIN, Michael

IPC: C07D495/04 ,  C07D513/04 ,  A61K31/519 ,  A61P35/00

CPC classification number: C07D495/04 ,  C07D513/04

Abstract: Compounds having the formula are useful for inhibiting protein tyrosine kinases. The present invention also discloses methods of making the compounds, compositions containing the compounds, and methods of treatment using the compounds.

公开(公告)号：EP1147101A1

公开(公告)日：2001-10-24

申请号：EP00905758.9

申请日：2000-01-27

Applicant: ABBOTT LABORATORIES

Inventor： CURTIN, Michael, L. ,  DAI, Yujia ,  DAVIDSEN, Steven, K. ,  HEYMAN, Howard, R. ,  HOLMES, James, H. ,  MICHAELIDES, Michael, R. ,  STEINMAN, Douglas, H.

IPC: C07D317/28 ,  C07D307/14 ,  C07D207/48 ,  C07D207/09 ,  C07D263/04 ,  A61K31/335 ,  A61P35/04

CPC classification number: C07D263/04 ,  C07D207/09 ,  C07D207/48 ,  C07D307/14 ,  C07D317/28

Abstract: Compounds having formula (I) are matric metalloproteinase inhibitors. Also disclosed are matrix metalloproteinase-inhibiting compositions and methods of inhibiting matrix metalloproteinase in a mammal.