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    PROCESS FOR THE PREPARATION AND ISOLATION OF ATRACURIUM BESYLATE
    1.
    发明申请
    PROCESS FOR THE PREPARATION AND ISOLATION OF ATRACURIUM BESYLATE 审中-公开
    苯甲酸钠的制备和分离方法

    公开(公告)号：WO1997030033A1

    公开(公告)日：1997-08-21

    申请号：PCT/US1997002196

    申请日：1997-02-12

    Applicant: ABBOTT LABORATORIES

    Inventor： ABBOTT LABORATORIES ,  CHAMBERLIN, Steven, A. ,  BHATIA, Ashok, V. ,  DAVIS, Deborah, A. ,  DRENGLER, Keith, A.

    IPC: C07D217/20

    CPC classification number: C07D217/20

    Abstract: A process of producing atracurium besylate that substantially reduces the level of impurities in the final product and avoids the repeated use of ether is provided. In accordance with such a process, N,N'-4,10-dioxa-3,11-dioxotridecylene-1,13-bis-tetrahydropapaverine (Compound 1), methyl benzenesulfonate and a catalytic amount of an insoluble base in a solvent are combined to form a reaction mixture that is maintained for a period of time sufficient for atracurium besylate formation. The reaction mixture is then filtered to remove the insoluble base and the atracurium besylate is precipitated.

    Abstract translation: 提供了大大降低最终产品中杂质水平并避免重复使用乙醚的苯磺酸阿曲库铵的方法。 按照这种方法，N，N'-4,10-二氧杂-3,11-二氧代二亚甲基-1,13-双 - 四氢吡哆胺（化合物1），苯磺酸甲酯和催化量的不溶碱在溶剂中是 合并形成反应混合物，该反应混合物保持足够长的苯磺酸阿卡库铵形成时间。 然后将反应混合物过滤以除去不溶性碱，并沉淀苯甲酸阿卡古铵。

    PROCESS FOR THE PREPARATION AND ISOLATION OF ATRACURIUM BESYLATE
    4.
    发明授权
    PROCESS FOR THE PREPARATION AND ISOLATION OF ATRACURIUM BESYLATE 失效
    方法用于生产和苯磺酸阿曲库铵的隔离

    公开(公告)号：EP0882020B1

    公开(公告)日：2001-04-11

    申请号：EP97905920.1

    申请日：1997-02-12

    Applicant: Abbott Laboratories

    Inventor： CHAMBERLIN, Steven, A. ,  BHATIA, Ashok, V. ,  DAVIS, Deborah, A. ,  DRENGLER, Keith, A.

    IPC: C07D217/20

    CPC classification number: C07D217/20

    Abstract: A process of producing atracurium besylate that substantially reduces the level of impurities in the final product and avoids the repeated use of ether is provided. In accordance with such a process, N,N'-4,10-dioxa-3,11-dioxotridecylene-1,13-bis-tetrahydropapaverine (Compound 1), methyl benzenesulfonate and a catalytic amount of an insoluble base in a solvent are combined to form a reaction mixture that is maintained for a period of time sufficient for atracurium besylate formation. The reaction mixture is then filtered to remove the insoluble base and the atracurium besylate is precipitated.

    PROCESS FOR THE PREPARATION AND ISOLATION OF ATRACURIUM BESYLATE
    5.
    发明公开
    PROCESS FOR THE PREPARATION AND ISOLATION OF ATRACURIUM BESYLATE 失效
    方法用于生产和苯磺酸阿曲库铵的隔离

    公开(公告)号：EP0882020A1

    公开(公告)日：1998-12-09

    申请号：EP97905920.0

    申请日：1997-02-12

    Applicant: Abbott Laboratories

    Inventor： CHAMBERLIN, Steven, A. ,  BHATIA, Ashok, V. ,  DAVIS, Deborah, A. ,  DRENGLER, Keith, A.

    IPC: C07D217

    CPC classification number: C07D217/20

    Abstract: A process of producing atracurium besylate that substantially reduces the level of impurities in the final product and avoids the repeated use of ether is provided. In accordance with such a process, N,N'-4,10-dioxa-3,11-dioxotridecylene-1,13-bis-tetrahydropapaverine (Compound 1), methyl benzenesulfonate and a catalytic amount of an insoluble base in a solvent are combined to form a reaction mixture that is maintained for a period of time sufficient for atracurium besylate formation. The reaction mixture is then filtered to remove the insoluble base and the atracurium besylate is precipitated.

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