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    PROCESS FOR THE PREPARATION AND ISOLATION OF ATRACURIUM BESYLATE
    1.
    发明申请
    PROCESS FOR THE PREPARATION AND ISOLATION OF ATRACURIUM BESYLATE 审中-公开
    苯甲酸钠的制备和分离方法

    公开(公告)号：WO1997030033A1

    公开(公告)日：1997-08-21

    申请号：PCT/US1997002196

    申请日：1997-02-12

    Applicant: ABBOTT LABORATORIES

    Inventor： ABBOTT LABORATORIES ,  CHAMBERLIN, Steven, A. ,  BHATIA, Ashok, V. ,  DAVIS, Deborah, A. ,  DRENGLER, Keith, A.

    IPC: C07D217/20

    CPC classification number: C07D217/20

    Abstract: A process of producing atracurium besylate that substantially reduces the level of impurities in the final product and avoids the repeated use of ether is provided. In accordance with such a process, N,N'-4,10-dioxa-3,11-dioxotridecylene-1,13-bis-tetrahydropapaverine (Compound 1), methyl benzenesulfonate and a catalytic amount of an insoluble base in a solvent are combined to form a reaction mixture that is maintained for a period of time sufficient for atracurium besylate formation. The reaction mixture is then filtered to remove the insoluble base and the atracurium besylate is precipitated.

    Abstract translation: 提供了大大降低最终产品中杂质水平并避免重复使用乙醚的苯磺酸阿曲库铵的方法。 按照这种方法，N，N'-4,10-二氧杂-3,11-二氧代二亚甲基-1,13-双 - 四氢吡哆胺（化合物1），苯磺酸甲酯和催化量的不溶碱在溶剂中是 合并形成反应混合物，该反应混合物保持足够长的苯磺酸阿卡库铵形成时间。 然后将反应混合物过滤以除去不溶性碱，并沉淀苯甲酸阿卡古铵。

    IMPROVED PROCESSES FOR THE PREPARATION OF D-CHIRO-INOSITOL
    2.
    发明申请
    IMPROVED PROCESSES FOR THE PREPARATION OF D-CHIRO-INOSITOL 审中-公开
    改进D-氟尿嘧啶的制备方法

    公开(公告)号：WO1996015088A1

    公开(公告)日：1996-05-23

    申请号：PCT/US1995014437

    申请日：1995-11-09

    Applicant: ABBOTT LABORATORIES

    Inventor： ABBOTT LABORATORIES ,  RILEY, David, A. ,  BHATIA, Ashok, V. ,  CHAMBERLIN, Steven, A. ,  ROBINSON, Gregg, E.

    IPC: C07C29/10

    CPC classification number: C07C69/013 ,  C07C29/095 ,  C07C35/16

    Abstract: A method for the preparation D-chiro-inositol (I) from kasugamycin (II), comprising the steps of: (a) reacting kasugamycin with an acetylating agent to form a crude hexa-acetate intermediate; (b) purifying the crude intermediate to form purified hexa-acetate intermediate; (c) deacetylating the purified intermediate to form D-chiro-inositol; and (d) isolating the D-chiro-inositol. The method permits efficient, large-scale preparation of D-chiro-inositol without the need for extensive chromatographic purification of the final D-chiro-inositol product.

    Abstract translation: 一种从春雷霉素（II）制备D-手性肌醇（I）的方法，包括以下步骤：（a）使春雷霉素与乙酰化试剂反应以形成六醋酸中间体; （b）纯化粗中间体以形成纯化的六醋酸酯中间体; （c）将纯化的中间体脱乙酰以形成D-手性肌醇; 和（d）分离D-手性肌醇。 该方法可有效，大规模地制备D-手性肌醇，而不需要对最终D-手性肌醇产品进行广泛的色谱纯化。

    PROCESS FOR THE PREPARATION AND ISOLATION OF ATRACURIUM BESYLATE
    7.
    发明授权
    PROCESS FOR THE PREPARATION AND ISOLATION OF ATRACURIUM BESYLATE 失效
    方法用于生产和苯磺酸阿曲库铵的隔离

    公开(公告)号：EP0882020B1

    公开(公告)日：2001-04-11

    申请号：EP97905920.1

    申请日：1997-02-12

    Applicant: Abbott Laboratories

    Inventor： CHAMBERLIN, Steven, A. ,  BHATIA, Ashok, V. ,  DAVIS, Deborah, A. ,  DRENGLER, Keith, A.

    IPC: C07D217/20

    CPC classification number: C07D217/20

    Abstract: A process of producing atracurium besylate that substantially reduces the level of impurities in the final product and avoids the repeated use of ether is provided. In accordance with such a process, N,N'-4,10-dioxa-3,11-dioxotridecylene-1,13-bis-tetrahydropapaverine (Compound 1), methyl benzenesulfonate and a catalytic amount of an insoluble base in a solvent are combined to form a reaction mixture that is maintained for a period of time sufficient for atracurium besylate formation. The reaction mixture is then filtered to remove the insoluble base and the atracurium besylate is precipitated.

    PROCESS FOR THE PREPARATION AND ISOLATION OF ATRACURIUM BESYLATE
    8.
    发明公开
    PROCESS FOR THE PREPARATION AND ISOLATION OF ATRACURIUM BESYLATE 失效
    方法用于生产和苯磺酸阿曲库铵的隔离

    公开(公告)号：EP0882020A1

    公开(公告)日：1998-12-09

    申请号：EP97905920.0

    申请日：1997-02-12

    Applicant: Abbott Laboratories

    Inventor： CHAMBERLIN, Steven, A. ,  BHATIA, Ashok, V. ,  DAVIS, Deborah, A. ,  DRENGLER, Keith, A.

    IPC: C07D217

    CPC classification number: C07D217/20

    Abstract: A process of producing atracurium besylate that substantially reduces the level of impurities in the final product and avoids the repeated use of ether is provided. In accordance with such a process, N,N'-4,10-dioxa-3,11-dioxotridecylene-1,13-bis-tetrahydropapaverine (Compound 1), methyl benzenesulfonate and a catalytic amount of an insoluble base in a solvent are combined to form a reaction mixture that is maintained for a period of time sufficient for atracurium besylate formation. The reaction mixture is then filtered to remove the insoluble base and the atracurium besylate is precipitated.

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