公开(公告)号：WO2015105981A2

公开(公告)日：2015-07-16

申请号：PCT/US2015/010631

申请日：2015-01-08

Applicant: ABBOTT LABORATORIES

Inventor： EDENS, Neile ,  GELLING, Richard ,  SATHYAVAGEESWARAN, Shreeram

IPC: A23L1/29

CPC classification number: A61K45/06 ,  A23L33/10 ,  A23L33/17 ,  A23V2002/00 ,  A23V2200/00 ,  A61K31/155 ,  A61K31/19 ,  A61K31/573 ,  A61K2300/00 ,  A23V2200/316

Abstract: A method of increasing or maintaining lean body mass in leucine conversion-compromised subjects and subjects undergoing treatment for diabetes is provided. The method includes administering an effective amount of β-hydroxy-β-methylbutyrate (HMB) to a subject with compromised leucine conversion efficiency or a subject undergoing treatment for insulin resistance associated with diabetes. Administration of HMB to a leucine conversion-compromised subject or a subject undergoing treatment for diabetes is effective to increase or maintain the human's lean body mass.

Abstract translation: 提供了一种增加或维持亮氨酸转化受损受试者和经历糖尿病治疗的受试者的瘦体重的方法。 该方法包括向具有降低的亮氨酸转化效率的受试者或经历与糖尿病相关的胰岛素抵抗治疗的受试者施用有效量的β-羟基-β-甲基丁酸酯（HMB）。 将HMB给予亮氨酸转化受损对象或正在接受糖尿病治疗的受试者有效地增加或维持人的瘦体重。