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1.发明申请PHARMACEUTICAL OR NUTRITIONAL COMBINATION COMPRISING BETA-HYDROXY-BETAMETHYLBUTYRATE 审中-公开包含β-羟基 - 丁酰基丁酸酯的药物或营养组合
公开(公告)号：WO2017127333A1
公开(公告)日：2017-07-27
申请号：PCT/US2017/013672
申请日：2017-01-16
Applicant: ABBOTT LABORATORIES
Inventor： SATHYAVAGEESWARAN, Shreeram
CPC classification number: A61K31/19 , A61K31/12 , A61K2300/00
Abstract: The present invention relates to a pharmaceutical or nutritional combination comprising beta-hydroxy beta-methylbutyrate (HMB) and tetrahydrocurcumin (THC) and methods comprising administering the combination to a subject. The methods of the invention relate to attenuating muscle protein degradation and/or preserving lean body mass in the subject.
Abstract translation: 本发明涉及包含β-羟基β-甲基丁酸酯（HMB）和四氢姜黄素（THC）的药物或营养组合，以及包括将所述组合施用于受试者的方法。 本发明的方法涉及减轻受试者的肌肉蛋白质降解和/或保持瘦体重。
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公开(公告)号：WO2015105981A2
公开(公告)日：2015-07-16
申请号：PCT/US2015/010631
申请日：2015-01-08
Applicant: ABBOTT LABORATORIES
Inventor： EDENS, Neile , GELLING, Richard , SATHYAVAGEESWARAN, Shreeram
IPC: A23L1/29
CPC classification number: A61K45/06 , A23L33/10 , A23L33/17 , A23V2002/00 , A23V2200/00 , A61K31/155 , A61K31/19 , A61K31/573 , A61K2300/00 , A23V2200/316
Abstract: A method of increasing or maintaining lean body mass in leucine conversion-compromised subjects and subjects undergoing treatment for diabetes is provided. The method includes administering an effective amount of β-hydroxy-β-methylbutyrate (HMB) to a subject with compromised leucine conversion efficiency or a subject undergoing treatment for insulin resistance associated with diabetes. Administration of HMB to a leucine conversion-compromised subject or a subject undergoing treatment for diabetes is effective to increase or maintain the human's lean body mass.
Abstract translation: 提供了一种增加或维持亮氨酸转化受损受试者和经历糖尿病治疗的受试者的瘦体重的方法。 该方法包括向具有降低的亮氨酸转化效率的受试者或经历与糖尿病相关的胰岛素抵抗治疗的受试者施用有效量的β-羟基-β-甲基丁酸酯（HMB）。 将HMB给予亮氨酸转化受损对象或正在接受糖尿病治疗的受试者有效地增加或维持人的瘦体重。
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Patent Agency Ranking3.发明申请BETA-HYDROXY-BETA-METHYLBUTRYIC ACID- CONTAINING COMPOSITIONS AND USES THEREOF 审中-公开含羟基 - 甲基含有羧酸的组合物及其用途
公开(公告)号：WO2014043685A1
公开(公告)日：2014-03-20
申请号：PCT/US2013/060120
申请日：2013-09-17
Applicant: ABBOTT LABORATORIES
Inventor： SATHYAVAGEESWARAN, Shreeram , VAZHAPPILLY, Rema , DAS, Tapas , GELLING, Richard Wayne
CPC classification number: A61K31/19 , A23L2/52 , A23L33/10 , A23L33/115 , A23L33/15 , A23L33/16 , A23L33/175 , A23L33/40 , A61K47/36 , A61K47/42 , A61K47/44
Abstract: Disclosed are compositions, such as liquid and solid nutritional compositions, that contain beta-hydroxy-beta-methylbutyric acid and optionally at least one protein, carbohydrate, fat, or a combination of protein, carbohydrate, and fat. Also disclosed are methods of using the compositions for improving physical endurance, locomotion, mobility and cognition in an individual, including a pediatric individual.
Abstract translation: 公开了含有β-羟基-β-甲基丁酸和任选的至少一种蛋白质，碳水化合物，脂肪或蛋白质，碳水化合物和脂肪的组合的组合物，例如液体和固体营养组合物。 还公开了使用组合物来改善包括儿科个体在内的个体的身体耐力，运动，移动性和认知的方法。
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4.发明申请
公开(公告)号：WO2013142424A1
公开(公告)日：2013-09-26
申请号：PCT/US2013/032831
申请日：2013-03-18
Applicant: ABBOTT LABORATORIES
Inventor： SATHYAVAGEESWARAN, Shreeram , DAS, Tapas , DAS, Srabani
CPC classification number: A61K31/19 , A23L33/40 , A23V2002/00
Abstract: The use beta-hydroxy-beta-methylbutyric acid for improving glucose tolerance in a pediatric individual or in an adult individual is disclosed. In certain embodiments, the beta-hydroxy-beta-methylbutyric acid is administered via a nutritional composition.
Abstract translation: 公开了用于改善儿科个体或成人个体中的葡萄糖耐量的β-羟基-β-甲基丁酸的用途。 在某些实施方案中，β-羟基-β-甲基丁酸通过营养组合物施用。
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公开(公告)号：EP3405186A1
公开(公告)日：2018-11-28
申请号：EP17702472.6
申请日：2017-01-16
Applicant: Abbott Laboratories
Inventor： SATHYAVAGEESWARAN, Shreeram
CPC classification number: A61K31/19 , A61K31/12 , A61K2300/00
Abstract: The present invention relates to a pharmaceutical or nutritional combination comprising beta-hydroxy beta-methylbutyrate (HMB) and tetrahydrocurcumin (THC) and methods comprising administering the combination to a subject. The methods of the invention relate to attenuating muscle protein degradation and/or preserving lean body mass in the subject.
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6.发明公开BETA-HYDROXY-BETA-METHYLBUTRYIC ACID- CONTAINING COMPOSITIONS AND USES THEREOF 审中-公开β-羟基BETA-METHYLBUTRYINSÄUREHALTIGE组合物及其应用
公开(公告)号：EP2895013A1
公开(公告)日：2015-07-22
申请号：EP13766463.7
申请日：2013-09-17
Applicant: ABBOTT LABORATORIES
Inventor： SATHYAVAGEESWARAN, Shreeram , VAZHAPPILLY, Rema , DAS, Tapas , GELLING, Richard Wayne
CPC classification number: A61K31/19 , A23L2/52 , A23L33/10 , A23L33/115 , A23L33/15 , A23L33/16 , A23L33/175 , A23L33/40 , A61K47/36 , A61K47/42 , A61K47/44
Abstract: Disclosed are compositions, such as liquid and solid nutritional compositions, that contain beta-hydroxy-beta-methylbutyric acid and optionally at least one protein, carbohydrate, fat, or a combination of protein, carbohydrate, and fat. Also disclosed are methods of using the compositions for improving physical endurance, locomotion, mobility and cognition in an individual, including a pediatric individual.
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7.发明公开
公开(公告)号：EP2827850A1
公开(公告)日：2015-01-28
申请号：EP13713057.1
申请日：2013-03-18
Applicant: ABBOTT LABORATORIES
Inventor： SATHYAVAGEESWARAN, Shreeram , DAS, Tapas , DAS, Srabani
CPC classification number: A61K31/19 , A23L33/40 , A23V2002/00
Abstract: The use beta-hydroxy-beta-methylbutyric acid for improving glucose tolerance in a pediatric individual or in an adult individual is disclosed. In certain embodiments, the beta-hydroxy-beta-methylbutyric acid is administered via a nutritional composition.
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