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公开(公告)号：WO2013067710A1
公开(公告)日：2013-05-16
申请号：PCT/CN2011/082108
申请日：2011-11-11
Applicant: ABBOTT LABORATORIES , ABBOTT LABORATORIES TRADING (SHANGHAI) COMPANY, LTD. , CURTIN, Michael L. , VASUDEVAN, Anil , WOLLER, Kevin R.
Inventor： CURTIN, Michael L. , VASUDEVAN, Anil , WOLLER, Kevin R.
IPC: C07D209/44 , C07D471/04 , A61K31/4035 , A61P3/10 , A61P11/06 , A61P13/12 , A61P17/00 , A61P17/06 , A61P19/04 , A61P19/10 , A61P25/28 , A61P29/00 , A61P31/18 , A61P35/00 , A61P37/00 , A61P43/00
CPC classification number: C07D209/44 , A61K31/4035 , A61K31/4178 , A61K31/501 , A61K31/5377 , A61K31/547 , A61K31/55 , A61K31/551 , C07D403/12 , C07D405/12 , C07D487/04 , C07D491/048 , C07D491/10 , C07D491/107
Abstract: Disclosed are compounds which inhibit the activity of NAMPT, compositions containing the compounds and methods of treating diseases during which NAMPT is expressed.
Abstract translation: 公开了抑制NAMPT活性的化合物，含有该化合物的组合物和治疗NAMPT表达的疾病的方法。
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公开(公告)号：WO2012097683A1
公开(公告)日：2012-07-26
申请号：PCT/CN2012/000102
申请日：2012-01-20
Applicant: ABBOTT LABORATORIES , ABBOTT LABORATORIES TRADING (SHANGHAI) COMPANY, LTD. , VASUDEVAN, Anil , PENNING, Thomas Dale , CHEN, Huanming , LIANG, Bo , WANG, Shaohui , ZHAO, Zhongqiang , CHAI, Dikun , YANG, Leifu , GAO, Yingxiang
Inventor： VASUDEVAN, Anil , PENNING, Thomas Dale , CHEN, Huanming , LIANG, Bo , WANG, Shaohui , ZHAO, Zhongqiang , CHAI, Dikun , YANG, Leifu , GAO, Yingxiang
IPC: C07D471/04 , C07D217/24 , C07D239/88 , A61K31/435 , A61K31/495 , A61P35/00
CPC classification number: C07D471/04 , C07D401/12
Abstract: The present invention relates to compounds of formula (1) or pharmaceutical acceptable salts, Formula (1) wherein R 1 , R 2 , R 3 , X, Y, Z, A, B, G 1 , m, and n are defined in the description. The present invention relates also to compositions containing said compounds which are useful for inhibiting kinases such as ALK and methods of treating diseases such as cancer.
Abstract translation: 本发明涉及式（1）化合物或其药学上可接受的盐，式（1）其中R 1，R 2，R 3，X，Y，Z，A，B，G 1，m和n在说明书中定义。 本发明还涉及含有可用于抑制ALK等激酶的化合物的组合物和治疗诸如癌症的疾病的方法。
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公开(公告)号：WO2012097684A1
公开(公告)日：2012-07-26
申请号：PCT/CN2012/000103
申请日：2012-01-20
Applicant: ABBOTT LABORATORIES , ABBOTT LABORATORIES TRADING (SHANGHAI) COMPANY, LTD. , VASUDEVAN, Anil , PENNING, Thomas Dale , CHEN, Huanming , LIANG, Bo , WANG, Shaohui , WU, Fengchun , SHEN, Yan , LIU, Cuihua , ZOU, Zhenguang
Inventor： VASUDEVAN, Anil , PENNING, Thomas Dale , CHEN, Huanming , LIANG, Bo , WANG, Shaohui , WU, Fengchun , SHEN, Yan , LIU, Cuihua , ZOU, Zhenguang
IPC: C07D487/04 , C07D471/04 , A61K31/519 , A61K31/4985 , A61K31/4353 , A61K31/5365 , A61P35/00
CPC classification number: C07D519/00 , A61K31/4353 , C07D471/04 , C07D487/04
Abstract: Compounds of formula (I) or pharmaceutical acceptable salts are provided, wherein X 1 ~X 5 , R 1 ~R 3 , A, B, Z and n are defined in the description. And compositions containing said compounds, and the uses for inhibitors of kinases such as ALK, and the uses for treating cancer thereof are provided.
Abstract translation: 提供式（I）化合物或药学上可接受的盐，其中X1〜X5，R1〜R3，A，B，Z和n在说明书中定义。 并提供含有所述化合物的组合物，以及用于激酶例如ALK的用途及其用于治疗癌症的用途。
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公开(公告)号：WO2012097682A1
公开(公告)日：2012-07-26
申请号：PCT/CN2012/000101
申请日：2012-01-20
Applicant: ABBOTT LABORATORIES , ABBOTT LABORATORIES TRADING (SHANGHAI) COMPANY, LTD. , VASUDEVAN, Anil , PENNING, Thomas Dale , CHEN, Huanming , LIANG, Bo , WANG, Shaohui , ZHAO, Zhongqiang , CHAI, Dikun , YANG, Leifu , GAO, Yingxiang
Inventor： VASUDEVAN, Anil , PENNING, Thomas Dale , CHEN, Huanming , LIANG, Bo , WANG, Shaohui , ZHAO, Zhongqiang , CHAI, Dikun , YANG, Leifu , GAO, Yingxiang
IPC: C07D471/04 , C07D239/88 , C07D237/32 , C07D243/14 , A61K31/435 , A61K31/495 , A61K31/551 , A61P35/00
CPC classification number: C07D471/04 , C07D401/12
Abstract: The present invention relates to compounds of formula (1) or pharmaceutical acceptable salts, wherein R 1 , X, Y, Z, A, B, G 1 , and n are defined in the description. The present invention relates also to compositions containing said compounds which are useful for inhibiting kinases such as ALK and methods of treating diseases such as cancer.
Abstract translation: 本发明涉及式（1）化合物或其药学上可接受的盐，其中R1，X，Y，Z，A，B，G1和n在说明书中定义。 本发明还涉及含有可用于抑制ALK等激酶的化合物的组合物和治疗诸如癌症的疾病的方法。
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公开(公告)号：WO2012149280A2
公开(公告)日：2012-11-01
申请号：PCT/US2012/035401
申请日：2012-04-27
Applicant: ABBOTT LABORATORIES , FRANK, Kristine E. , BURCHAT, Andrew , COX, Philip , IHLE, David C. , MULLEN, Kelly D. , SOMAL, Gagandeep , VASUDEVAN, Anil , WANG, Lu , WILSON, Noel S.
Inventor： FRANK, Kristine E. , BURCHAT, Andrew , COX, Philip , IHLE, David C. , MULLEN, Kelly D. , SOMAL, Gagandeep , VASUDEVAN, Anil , WANG, Lu , WILSON, Noel S.
IPC: A61K31/519
CPC classification number: C07D487/14
Abstract: The invention provides compounds of Formula (I), pharmaceutically acceptable salts, pro-drugs, biologically active metabolites, stereoisomers and isomers thereof wherein the variable are defined herein. The compounds of the invention are useful for treating immunological and oncological conditions.
Abstract translation: 本发明提供式（I）的化合物，其药学上可接受的盐，前药，生物活性代谢物，立体异构体和异构体，其中变量在本文中定义。 本发明的化合物可用于治疗免疫学和肿瘤学病症。
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Patent Agency Ranking
公开(公告)号：WO2009089083A1
公开(公告)日：2009-07-16
申请号：PCT/US2009/030006
申请日：2009-01-02
Applicant: ABBOTT LABORATORIES , PERNER, Richard J. , KORT, Michael E. , DIDOMENICO, Stanley, Jr. , CHEN, Jun , VASUDEVAN, Anil
Inventor： PERNER, Richard J. , KORT, Michael E. , DIDOMENICO, Stanley, Jr. , CHEN, Jun , VASUDEVAN, Anil
IPC: C07D213/53 , C07D215/12 , C07D217/14 , C07D333/20 , A61K31/4406 , A61P29/00
CPC classification number: C07D333/22 , A61K31/381 , A61K31/44 , A61K31/47 , A61K31/472 , A61K45/06 , C07D213/53 , C07D213/61 , C07D213/64 , C07D215/12 , C07D217/14 , C07D333/20
Abstract: Compounds of formula (I), wherein R 1 , R 2 , R 3 , and Y are defined in the description are TRPA1 antagonists. Compositions comprising such compounds and methods for treating conditions and disorders using such compounds and compositions are also disclosed.
Abstract translation: 其中R1，R2，R3和Y在说明书中定义的式（I）化合物是TRPA1拮抗剂。 还公开了包含这些化合物的组合物和使用这些化合物和组合物治疗病症和病症的方法。
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7.发明申请1,3-DISUBSTITUTED AND 1,3,3,-TRISUBSTITUTED PYRROLIDINES AS HISTAMINE-3 RECEPTOR LIGANDS AND THEIR THERAPEUTIC APPLICATIONS 审中-公开作为组胺-3受体配体及其治疗应用的1,3 - 取代的1,3,3 - 衍生吡咯烷
公开(公告)号：WO2003059341A1
公开(公告)日：2003-07-24
申请号：PCT/US2003/000703
申请日：2003-01-10
Applicant: ABBOTT LABORATORIES
Inventor： BENNANI, Youssef, L. , FAGHIH, Ramin , DWIGHT, Wesley, J. , VASUDEVAN, Anil , CONNER, Scott, E.
IPC: A61K31/40
CPC classification number: C07D403/04 , C07D207/12 , C07D207/14 , C07D207/24 , C07D401/04 , C07D401/12 , C07D401/14 , C07D403/12 , C07D405/12 , C07D409/12 , C07D417/12 , C07D417/14
Abstract: Compounds of formula I, are useful in treating diseases or conditions prevented by or ameliorated with histamine-3 receptor ligands. Also disclosed are histamine-3 receptor ligand compositions and methods of antagonizing or agonizing histamine-3 receptors.
Abstract translation: 式I化合物可用于治疗用组胺-3受体配体预防或改善的疾病或病症。 还公开了组胺-3受体配体组合物和拮抗或激动组胺3受体的方法。
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公开(公告)号：WO2012097479A1
公开(公告)日：2012-07-26
申请号：PCT/CN2011/000110
申请日：2011-01-21
Applicant: ABBOTT LABORATORIES , VASUDEVAN, Anil , PENNING, Thomas, Dale , CHEN, Huanming , LIANG, Bo , WANG, Shaohui , ZHAO, Zhongqiang , CHAI, Dikun , YANG, Leifu , GAO, Yingxiang
Inventor： VASUDEVAN, Anil , PENNING, Thomas, Dale , CHEN, Huanming , LIANG, Bo , WANG, Shaohui , ZHAO, Zhongqiang , CHAI, Dikun , YANG, Leifu , GAO, Yingxiang
IPC: C07D471/04 , A61K31/4375 , A61K31/4985 , A61P35/00
CPC classification number: C07D471/04 , C07D401/12
Abstract: Disclosed are compounds of formula (Ⅰ) and their pharmaceutical acceptable salts, wherein R 1 , R 2 , R 3 , X, Y, Z, A, B, G 1 , m and n are defined in the description. The compositions containing the said compounds used for inhibiting kinases such as anaphastic lymphoma kinase (ALK) and methods of treating diseases such as cancer are disclosed.
Abstract translation: 公开了式（◎）化合物及其药学上可接受的盐，其中R1，R2，R3，X，Y，Z，A，B，G1，m和n在说明书中定义。 公开了含有用于抑制激酶例如无痛性淋巴瘤激酶（ALK）的所述化合物的组合物和治疗诸如癌症的疾病的方法。
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公开(公告)号：WO2012067965A1
公开(公告)日：2012-05-24
申请号：PCT/US2011/060425
申请日：2011-11-11
Applicant: ABBOTT LABORATORIES , CURTIN, Michael L. , SORENSEN, Bryan K. , HEYMAN, Howard R. , CLARK, Richard F. , WOLLER, Kevin R. , SHAH, Omar J. , MICHAELIDES, Michael , TSE, Chris , VASUDEVAN, Anil , MACK, Helmut , HANSEN, Todd M. , SWEIS, Ramzi , PLIUSHCHEV, Marina A.
Inventor： CURTIN, Michael L. , SORENSEN, Bryan K. , HEYMAN, Howard R. , CLARK, Richard F. , WOLLER, Kevin R. , SHAH, Omar J. , MICHAELIDES, Michael , TSE, Chris , VASUDEVAN, Anil , MACK, Helmut , HANSEN, Todd M. , SWEIS, Ramzi , PLIUSHCHEV, Marina A.
IPC: C07D209/44 , C07D403/12 , C07D407/12 , C07D407/14 , C07D413/12 , C07D471/04 , A61K31/4035 , A61K31/407 , A61P35/00 , A61P9/10
CPC classification number: C07D209/44 , A61K31/437 , A61K31/496 , A61K31/4985 , A61K31/501 , A61K31/506 , A61K31/5377 , C07D401/12 , C07D401/14 , C07D403/10 , C07D403/12 , C07D403/14 , C07D405/12 , C07D407/12 , C07D407/14 , C07D413/12 , C07D417/12 , C07D471/04 , C07D491/048 , C07D495/04 , C07D519/00
Abstract: Disclosed are compounds of formula (1c) which inhibit the activity of NAMPT, compositions containing the compounds and methods of treating diseases during which NAMPT is expressed. Disclosed are compounds which inhibit the activity of ROCK, compositions containing the compounds and methods of treating diseases during which ROCK is expressed.
Abstract translation: 公开了抑制NAMPT活性的式（1c）化合物，含有该化合物的组合物和治疗其中NAMPT表达的疾病的方法。 公开了抑制ROCK活性的化合物，含有化合物的组合物和治疗ROCK表达疾病的方法。
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公开(公告)号：WO2012061602A1
公开(公告)日：2012-05-10
申请号：PCT/US2011/059154
申请日：2011-11-03
Applicant: ABBOTT LABORATORIES , MATULENKO, Mark , JINKERSON, Tammie , BROWN, Brian, S. , BRAJE, Wilfried , CURTIN, Michael , HEYMAN, Howard, Robin , SCOTT, Victoria , KAGE, Karen , CASSAR, Steven , VASUDEVAN, Anil
Inventor： MATULENKO, Mark , JINKERSON, Tammie , BROWN, Brian, S. , BRAJE, Wilfried , CURTIN, Michael , HEYMAN, Howard, Robin , SCOTT, Victoria , KAGE, Karen , CASSAR, Steven , VASUDEVAN, Anil
IPC: C07D209/46 , C07D401/12 , C07D405/12 , C07D413/12 , A61K31/4035 , A61P35/04
CPC classification number: C07D209/46 , C07D401/12 , C07D405/12 , C07D409/12 , C07D413/12 , C07D417/12
Abstract: Compounds having the formula (I) are useful for inhibiting protein kinases. The present invention also discloses methods of making the compounds, compositions containing the compounds, and methods of treatment using the compounds.
Abstract translation: 具有式（I）的化合物可用于抑制蛋白激酶。 本发明还公开了制备化合物的方法，含有该化合物的组合物和使用该化合物的处理方法。
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